Dietary component isorhamnetin is a PPARγ antagonist and ameliorates metabolic disorders induced by diet or leptin deficiency View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05

AUTHORS

Yu Zhang, Ming Gu, Wujie Cai, Lijing Yu, Li Feng, Lu Zhang, Qingqing Zang, Yahui Wang, Dongshan Wang, Hui Chen, Qingchun Tong, Guang Ji, Cheng Huang

ABSTRACT

Studies on peroxisome proliferator-activated receptor (PPAR)-γ ligands have been focused on agonists. However, PPARγ activation may induce obesity and nonalcoholic fatty liver disease (NAFLD), one of the most challenging medical conditions. Here, we identified that isorhamnetin, a naturally occurring compound in fruits and vegetables and the metabolite of quercetin, is a novel antagonist of PPARγ. Isorhamnetin treatment inhibited the adipocyte differentiation induced by the PPARγ agonist rosiglitazone, reduced obesity development and ameliorated hepatic steatosis induced by both high-fat diet treatment and leptin deficiency. Our results suggest that dietary supplement of isorhamnetin may be beneficial to prevent obesity and steatosis and PPARγ antagonists may be useful to treat hepatic steatosis. More... »

PAGES

19288

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep19288

DOI

http://dx.doi.org/10.1038/srep19288

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009018928

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26775807


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