Blood-based gene expression signatures of medication-free outpatients with major depressive disorder: integrative genome-wide and candidate gene analyses View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05

AUTHORS

Hiroaki Hori, Daimei Sasayama, Toshiya Teraishi, Noriko Yamamoto, Seiji Nakamura, Miho Ota, Kotaro Hattori, Yoshiharu Kim, Teruhiko Higuchi, Hiroshi Kunugi

ABSTRACT

Several microarray-based studies have investigated gene expression profiles in major depressive disorder (MDD), yet with highly variable findings. We examined blood-based genome-wide expression signatures of MDD, focusing on molecular pathways and networks underlying differentially expressed genes (DEGs) and behaviours of hypothesis-driven, evidence-based candidate genes for depression. Agilent human whole-genome arrays were used to measure gene expression in 14 medication-free outpatients with MDD who were at least moderately ill and 14 healthy controls matched pairwise for age and sex. After filtering, we compared expression of entire probes between patients and controls and identified DEGs. The DEGs were evaluated by pathway and network analyses. For the candidate gene analysis, we utilized 169 previously prioritized genes and examined their case-control separation efficiency and correlational co-expression network in patients relative to controls. The 317 screened DEGs mapped to a significantly over-represented pathway, the "synaptic transmission" pathway. The protein-protein interaction network was also significantly enriched, in which a number of key molecules for depression were included. The co-expression network of candidate genes was markedly disrupted in patients. This study provided evidence for an altered molecular network along with several key molecules in MDD and confirmed that the candidate genes are worthwhile targets for depression research. More... »

PAGES

18776

References to SciGraph publications

  • 2014-09. Blood transcriptomic biomarkers in adult primary care patients with major depressive disorder undergoing cognitive behavioral therapy in TRANSLATIONAL PSYCHIATRY
  • 2010-10. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia in MOLECULAR PSYCHIATRY
  • 2003-05. Clustering gene-expression data with repeated measurements in GENOME BIOLOGY
  • 2014-12. The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder in BMC MEDICINE
  • 2008-08. The environmental contribution to gene expression profiles in NATURE REVIEWS GENETICS
  • 2010-04. Gene Expression Studies in Major Depression in CURRENT PSYCHIATRY REPORTS
  • 2014-12. An investigation of biomarkers derived from legacy microarray data for their utility in the RNA-seq era in GENOME BIOLOGY
  • 2011-01. Network medicine: a network-based approach to human disease in NATURE REVIEWS GENETICS
  • 2014-12. Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing in MOLECULAR PSYCHIATRY
  • 2013-02. Reuse of public genome-wide gene expression data in NATURE REVIEWS GENETICS
  • 2013-12. Depression pathogenesis and treatment: what can we learn from blood mRNA expression? in BMC MEDICINE
  • 2009-01. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources in NATURE PROTOCOLS
  • 2012-11. Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episode in TRANSLATIONAL PSYCHIATRY
  • 2009-02. Identifying blood biomarkers for mood disorders using convergent functional genomics in MOLECULAR PSYCHIATRY
  • 2012-01. Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models in MOLECULAR PSYCHIATRY
  • 2006-09. The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements in NATURE BIOTECHNOLOGY
  • 2012-05. Dexamethasone Stimulated Gene Expression in Peripheral Blood is a Sensitive Marker for Glucocorticoid Receptor Resistance in Depressed Patients in NEUROPSYCHOPHARMACOLOGY
  • 2016-03. Gene expression in major depressive disorder in MOLECULAR PSYCHIATRY
  • 2010-05. Between a chicken and a grape: estimating the number of human genes in GENOME BIOLOGY
  • 2005-05. Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors in MOLECULAR PSYCHIATRY
  • 2014-09. The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance in NATURE BIOTECHNOLOGY
  • 2015-02. Testing the Predictive Value of Peripheral Gene Expression for Nonremission Following Citalopram Treatment for Major Depression in NEUROPSYCHOPHARMACOLOGY
  • 2010-01. Blood mononuclear cell gene expression signature of postpartum depression in MOLECULAR PSYCHIATRY
  • 2009-09-10. Molecular networks as sensors and drivers of common human diseases in NATURE
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    http://scigraph.springernature.com/pub.10.1038/srep18776

    DOI

    http://dx.doi.org/10.1038/srep18776

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1050617500

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26728011


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