Immune cell impact of three differently coated lipid nanocapsules: pluronic, chitosan and polyethylene glycol View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05

AUTHORS

Cristiano Farace, Paola Sánchez-Moreno, Marco Orecchioni, Roberto Manetti, Francesco Sgarrella, Yolande Asara, José M Peula-García, Juan A Marchal, Roberto Madeddu, Lucia G Delogu

ABSTRACT

Lipid nanocapsules (NCs) represent promising tools in clinical practice for diagnosis and therapy applications. However, the NC appropriate functionalization is essential to guarantee high biocompatibility and molecule loading ability. In any medical application, the immune system-impact of differently functionalized NCs still remains to be fully understood. A comprehensive study on the action exerted on human peripheral blood mononuclear cells (PBMCs) and major immune subpopulations by three different NC coatings: pluronic, chitosan and polyethylene glycol-polylactic acid (PEG) is reported. After a deep particle characterization, the uptake was assessed by flow-cytometry and confocal microscopy, focusing then on apoptosis, necrosis and proliferation impact in T cells and monocytes. Cell functionality by cell diameter variations, different activation marker analysis and cytokine assays were performed. We demonstrated that the NCs impact on the immune cell response is strongly correlated to their coating. Pluronic-NCs were able to induce immunomodulation of innate immunity inducing monocyte activations. Immunomodulation was observed in monocytes and T lymphocytes treated with Chitosan-NCs. Conversely, PEG-NCs were completely inert. These findings are of particular value towards a pre-selection of specific NC coatings depending on biomedical purposes for pre-clinical investigations; i.e. the immune-specific action of particular NC coating can be excellent for immunotherapy applications. More... »

PAGES

18423

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep18423

    DOI

    http://dx.doi.org/10.1038/srep18423

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041676639

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26728491


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