HIV-1 CCR5 gene therapy will fail unless it is combined with a suicide gene View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12-17

AUTHORS

Aridaman Pandit, Rob J. de Boer

ABSTRACT

Highly active antiretroviral therapy (ART) has successfully turned Human immunodeficiency virus type 1 (HIV-1) from a deadly pathogen into a manageable chronic infection. ART is a lifelong therapy which is both expensive and toxic and HIV can become resistant to it. An alternative to lifelong ART is gene therapy that targets the CCR5 co-receptor and creates a population of genetically modified host cells that are less susceptible to viral infection. With generic mathematical models we show that gene therapy that only targets the CCR5 co-receptor fails to suppress HIV-1 (which is in agreement with current data). We predict that the same gene therapy can be markedly improved if it is combined with a suicide gene that is only expressed upon HIV-1 infection. More... »

PAGES

18088

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep18088

DOI

http://dx.doi.org/10.1038/srep18088

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015775431

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26674113


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