Ontology type: schema:ScholarlyArticle Open Access: True
2016-05
AUTHORSAndrew Dhawan, Seyed Ali Madani Tonekaboni, Joseph H Taube, Stephen Hu, Nathalie Sphyris, Sendurai A Mani, Mohammad Kohandel
ABSTRACTHypoxia, or oxygen deficiency, is known to be associated with breast tumour progression, resistance to conventional therapies and poor clinical prognosis. The epithelial-mesenchymal transition (EMT) is a process that confers invasive and migratory capabilities as well as stem cell properties to carcinoma cells thus promoting metastatic progression. In this work, we examined the impact of hypoxia on EMT-associated cancer stem cell (CSC) properties, by culturing transformed human mammary epithelial cells under normoxic and hypoxic conditions, and applying in silico mathematical modelling to simulate the impact of hypoxia on the acquisition of CSC attributes and the transitions between differentiated and stem-like states. Our results indicate that both the heterogeneity and the plasticity of the transformed cell population are enhanced by exposure to hypoxia, resulting in a shift towards a more stem-like population with increased EMT features. Our findings are further reinforced by gene expression analyses demonstrating the upregulation of EMT-related genes, as well as genes associated with therapy resistance, in hypoxic cells compared to normoxic counterparts. In conclusion, we demonstrate that mathematical modelling can be used to simulate the role of hypoxia as a key contributor to the plasticity and heterogeneity of transformed human mammary epithelial cells. More... »
PAGES18074
http://scigraph.springernature.com/pub.10.1038/srep18074
DOIhttp://dx.doi.org/10.1038/srep18074
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1025627224
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26838463
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Hypoxia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Epithelial-Mesenchymal Transition",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Models, Biological",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplastic Stem Cells",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Queen's University",
"id": "https://www.grid.ac/institutes/grid.410356.5",
"name": [
"School of Medicine, Queen's University, Kingston, Ontario, Canada."
],
"type": "Organization"
},
"familyName": "Dhawan",
"givenName": "Andrew",
"id": "sg:person.0631576774.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631576774.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Waterloo",
"id": "https://www.grid.ac/institutes/grid.46078.3d",
"name": [
"Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada."
],
"type": "Organization"
},
"familyName": "Madani Tonekaboni",
"givenName": "Seyed Ali",
"id": "sg:person.0600612067.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600612067.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Centre, Houston, Texas, United States of America."
],
"type": "Organization"
},
"familyName": "Taube",
"givenName": "Joseph H",
"id": "sg:person.0633352254.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633352254.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Centre, Houston, Texas, United States of America."
],
"type": "Organization"
},
"familyName": "Hu",
"givenName": "Stephen",
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Centre, Houston, Texas, United States of America."
],
"type": "Organization"
},
"familyName": "Sphyris",
"givenName": "Nathalie",
"id": "sg:person.01064027254.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064027254.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Centre, Houston, Texas, United States of America.",
"Metastasis Research Centre, The University of Texas MD Anderson Cancer Centre, Houston, Texas, United States of America."
],
"type": "Organization"
},
"familyName": "Mani",
"givenName": "Sendurai A",
"id": "sg:person.01372144100.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372144100.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Fields Institute for Research in Mathematical Sciences",
"id": "https://www.grid.ac/institutes/grid.249304.8",
"name": [
"Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada.",
"Centre for Mathematical Medicine, Fields Institute for Research in Mathematical Sciences, Toronto, Ontario, Canada."
],
"type": "Organization"
},
"familyName": "Kohandel",
"givenName": "Mohammad",
"id": "sg:person.01217703241.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217703241.62"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nature07733",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000048827",
"https://doi.org/10.1038/nature07733"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07733",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000048827",
"https://doi.org/10.1038/nature07733"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcb.21215",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000050423"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-07-1755",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000370007"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molmed.2008.03.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000471581"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0802047105",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002568216"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1004900107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003168562"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.canlet.2007.09.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003558564"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1061803",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004107821"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00018-007-7082-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006294702",
"https://doi.org/10.1007/s00018-007-7082-2"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2013.06.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007254293"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m610156200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010821824"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/msb.2013.65",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012285467"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/msb.2013.65",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012285467"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm.2401",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013306597",
"https://doi.org/10.1038/nm.2401"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1634/stemcells.2007-0724",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013860937"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/carcin/bgn216",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015582790"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/bcr315",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016954738",
"https://doi.org/10.1186/bcr315"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/bcr315",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016954738",
"https://doi.org/10.1186/bcr315"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1947601910368059",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018200114"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1947601910368059",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018200114"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6600859",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019263657",
"https://doi.org/10.1038/sj.bjc.6600859"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6600859",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019263657",
"https://doi.org/10.1038/sj.bjc.6600859"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1102454108",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019813663"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/aso.2005.04.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019924385",
"https://doi.org/10.1245/aso.2005.04.010"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.semradonc.2008.12.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020910546"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-06-2044",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025016528"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms6203",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025818132",
"https://doi.org/10.1038/ncomms6203"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/carcin/bgt209",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027913537"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2004.06.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028124707"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc704",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028740665",
"https://doi.org/10.1038/nrc704"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc704",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028740665",
"https://doi.org/10.1038/nrc704"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/367645a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028822583",
"https://doi.org/10.1038/367645a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc2540",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029171620",
"https://doi.org/10.1038/nrc2540"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0064169",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032195636"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci59735",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035104897"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/bcr2912",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037200519",
"https://doi.org/10.1186/bcr2912"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0506580102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037705714"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0506580102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037705714"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00109-007-0281-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038425944",
"https://doi.org/10.1007/s00109-007-0281-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00109-007-0281-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038425944",
"https://doi.org/10.1007/s00109-007-0281-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2008.03.027",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042567148"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2011.11.016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042731192"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0305-7372(03)00003-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043218794"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0305-7372(03)00003-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043218794"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/onc.2014.245",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043471529",
"https://doi.org/10.1038/onc.2014.245"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0007181",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046574877"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gkn923",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047610281"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcp.1041180311",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050585506"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2012.09.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050870651"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1691",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051063203",
"https://doi.org/10.1038/ncb1691"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2011.07.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053327451"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc2419",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053441127",
"https://doi.org/10.1038/nrc2419"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/j100540a008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055672411"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1259/0007-1285-26-312-638",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064544114"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/cc.8.20.9701",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072300363"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075262310",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078589595",
"type": "CreativeWork"
}
],
"datePublished": "2016-05",
"datePublishedReg": "2016-05-01",
"description": "Hypoxia, or oxygen deficiency, is known to be associated with breast tumour progression, resistance to conventional therapies and poor clinical prognosis. The epithelial-mesenchymal transition (EMT) is a process that confers invasive and migratory capabilities as well as stem cell properties to carcinoma cells thus promoting metastatic progression. In this work, we examined the impact of hypoxia on EMT-associated cancer stem cell (CSC) properties, by culturing transformed human mammary epithelial cells under normoxic and hypoxic conditions, and applying in silico mathematical modelling to simulate the impact of hypoxia on the acquisition of CSC attributes and the transitions between differentiated and stem-like states. Our results indicate that both the heterogeneity and the plasticity of the transformed cell population are enhanced by exposure to hypoxia, resulting in a shift towards a more stem-like population with increased EMT features. Our findings are further reinforced by gene expression analyses demonstrating the upregulation of EMT-related genes, as well as genes associated with therapy resistance, in hypoxic cells compared to normoxic counterparts. In conclusion, we demonstrate that mathematical modelling can be used to simulate the role of hypoxia as a key contributor to the plasticity and heterogeneity of transformed human mammary epithelial cells. ",
"genre": "research_article",
"id": "sg:pub.10.1038/srep18074",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2481213",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2438826",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "6"
}
],
"name": "Mathematical modelling of phenotypic plasticity and conversion to a stem-cell state under hypoxia",
"pagination": "18074",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"7a16bfa5f6da58568083f0edd7807339d5937c8acf2f30d0c48208e66a26bcef"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"26838463"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101563288"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/srep18074"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1025627224"
]
}
],
"sameAs": [
"https://doi.org/10.1038/srep18074",
"https://app.dimensions.ai/details/publication/pub.1025627224"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T15:58",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000550.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/srep/2016/160203/srep18074/full/srep18074.html"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep18074'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep18074'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep18074'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep18074'
This table displays all metadata directly associated to this object as RDF triples.
312 TRIPLES
21 PREDICATES
85 URIs
28 LITERALS
16 BLANK NODES