Self-directed exploration provides a Ncs1-dependent learning bonus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11

AUTHORS

Ho-Suk Mun, Bechara J Saab, Enoch Ng, Alexander McGirr, Tatiana V Lipina, Yoichi Gondo, John Georgiou, John C Roder

ABSTRACT

Understanding the mechanisms of memory formation is fundamental to establishing optimal educational practices and restoring cognitive function in brain disease. Here, we show for the first time in a non-primate species, that spatial learning receives a special bonus from self-directed exploration. In contrast, when exploration is escape-oriented, or when the full repertoire of exploratory behaviors is reduced, no learning bonus occurs. These findings permitted the first molecular and cellular examinations into the coupling of exploration to learning. We found elevated expression of neuronal calcium sensor 1 (Ncs1) and dopamine type-2 receptors upon self-directed exploration, in concert with increased neuronal activity in the hippocampal dentate gyrus and area CA3, as well as the nucleus accumbens. We probed further into the learning bonus by developing a point mutant mouse (Ncs1(P144S/P144S)) harboring a destabilized NCS-1 protein, and found this line lacked the equivalent self-directed exploration learning bonus. Acute knock-down of Ncs1 in the hippocampus also decoupled exploration from efficient learning. These results are potentially relevant for augmenting learning and memory in health and disease, and provide the basis for further molecular and circuit analyses in this direction. More... »

PAGES

17697

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep17697

DOI

http://dx.doi.org/10.1038/srep17697

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023628241

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26639399


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CA3 Region, Hippocampal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dentate Gyrus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Environment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Exploratory Behavior", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Knockdown Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Learning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuronal Calcium-Sensor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuropeptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleus Accumbens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-fos", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Dopamine D2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spatial Memory", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.", 
            "Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mun", 
        "givenName": "Ho-Suk", 
        "id": "sg:person.01014263307.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014263307.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Zurich", 
          "id": "https://www.grid.ac/institutes/grid.7400.3", 
          "name": [
            "Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.", 
            "Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.", 
            "Preclinical Laboratory for Translational Research into Affective Disorders, University of Zurich Hospital for Psychiatry, August-Forel-Str 7, CH-8008, Zurich, Switzerland.", 
            "Neuroscience Center Zurich, Zurich, CH-8057, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saab", 
        "givenName": "Bechara J", 
        "id": "sg:person.01040231156.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040231156.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.", 
            "Institute of Medical Science, University of Toronto, Toronto, ON, M5S 1A8, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ng", 
        "givenName": "Enoch", 
        "id": "sg:person.0702243767.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702243767.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.", 
            "Department of Psychiatry, University of British Columbia, Vancouver, BC, V6T 2A1, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "McGirr", 
        "givenName": "Alexander", 
        "id": "sg:person.01043413110.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043413110.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Institute of Physiology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.466471.6", 
          "name": [
            "Federal State Budgetary Scientific Institution, Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, 630117, Russia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lipina", 
        "givenName": "Tatiana V", 
        "id": "sg:person.0716550245.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716550245.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RIKEN", 
          "id": "https://www.grid.ac/institutes/grid.7597.c", 
          "name": [
            "Mutagenesis and Genomics Team, RIKEN BioResource Center, Tsukuba 305-0074, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gondo", 
        "givenName": "Yoichi", 
        "id": "sg:person.01111452372.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111452372.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Georgiou", 
        "givenName": "John", 
        "id": "sg:person.01132720767.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132720767.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.", 
            "Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.", 
            "Institute of Medical Science, University of Toronto, Toronto, ON, M5S 1A8, Canada.", 
            "Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roder", 
        "givenName": "John C", 
        "id": "sg:person.011306114245.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011306114245.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0896-6273(01)00276-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000284162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/h0043788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001688369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mus.22210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002035217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1207/s15326985ep4102_3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002411906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(00)01008-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002876565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2005.01.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002955611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-2952(03)00187-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005157864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-2952(03)00187-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005157864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rspb.2014.2516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005975628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hipo.1071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006501164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/revneuro.2006.17.1-2.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006608081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-4328(02)00238-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011817633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3940(02)01418-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013618643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3940(02)01418-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013618643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2012.09.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013942293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.055095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014282539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/h0046577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016337716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.20831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016544382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0706900104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016731921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.2693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019287546", 
          "https://doi.org/10.1038/nn.2693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(01)00301-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020259592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/328632a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021930315", 
          "https://doi.org/10.1038/328632a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2015.240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023331073", 
          "https://doi.org/10.1038/npp.2015.240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2008.06.075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024149481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ne.15.030192.002033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028820203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nlm.2009.09.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031475066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2009.08.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033355935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2009.07042.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033778541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2009.07042.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033778541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hipo.10005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036756340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn2093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037709801", 
          "https://doi.org/10.1038/nrn2093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0461-11.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040507314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00217.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041735497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/h0040546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042995051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nlm.2013.07.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043266182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2008.10.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043436388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5331-09.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043597074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnins.2013.00053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043648127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.conb.2004.03.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043785216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4970-03.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045639203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/0023-8333.81997008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048946530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.physbeh.2014.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053066744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1467-9450.2005.00443.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053073901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02568540709594622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053621150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.281.5380.1185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062562202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3037702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062584475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.56.10.1377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064379259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.56.10.1377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064379259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.56.10.1377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064379259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.56.10.1377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064379259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12968/bjon.2009.18.10.42485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064791483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.22-19-08476.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075167137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.22-23-10067.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075195958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/11164-000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1109386037"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-11", 
    "datePublishedReg": "2016-11-01", 
    "description": "Understanding the mechanisms of memory formation is fundamental to establishing optimal educational practices and restoring cognitive function in brain disease. Here, we show for the first time in a non-primate species, that spatial learning receives a special bonus from self-directed exploration. In contrast, when exploration is escape-oriented, or when the full repertoire of exploratory behaviors is reduced, no learning bonus occurs. These findings permitted the first molecular and cellular examinations into the coupling of exploration to learning. We found elevated expression of neuronal calcium sensor 1 (Ncs1) and dopamine type-2 receptors upon self-directed exploration, in concert with increased neuronal activity in the hippocampal dentate gyrus and area CA3, as well as the nucleus accumbens. We probed further into the learning bonus by developing a point mutant mouse (Ncs1(P144S/P144S)) harboring a destabilized NCS-1 protein, and found this line lacked the equivalent self-directed exploration learning bonus. Acute knock-down of Ncs1 in the hippocampus also decoupled exploration from efficient learning. These results are potentially relevant for augmenting learning and memory in health and disease, and provide the basis for further molecular and circuit analyses in this direction. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep17697", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5878326", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6111507", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "Self-directed exploration provides a Ncs1-dependent learning bonus", 
    "pagination": "17697", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "70924c7db1c2babdb09a9ea537636d3e99bfa20a085c7e6694aceb04007aab0d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26639399"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep17697"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1023628241"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep17697", 
      "https://app.dimensions.ai/details/publication/pub.1023628241"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000586.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2015/151207/srep17697/full/srep17697.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep17697'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep17697'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep17697'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep17697'


 

This table displays all metadata directly associated to this object as RDF triples.

350 TRIPLES      21 PREDICATES      92 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep17697 schema:about N1b4a24a587784c649ebe3ebda610a0b7
2 N1beb5d6635d24162881debe39144504c
3 N1ef7f025550a4deb938d7881b4158406
4 N2a584374b4f0403bbe624a5209a20131
5 N4d42bbe2b4fd409c88045e85a906fb38
6 N57ced80a7a254b009ccaf148c861a3cd
7 N8233937148ad49afb7fe235102ed17db
8 Nb151d94ec68d49459618635ffe7d0c32
9 Nbf5ae9e8cffe452caa8ce79c1e6850e1
10 Ncd7baad6b442403b86c83e0e2dbcf38d
11 Nd0f37b4f6400495ba3106f74bafce9fd
12 Ndfbd97d4ea764ecd9ea102cdf6665677
13 Nf0ec2944ad584b448bbac97848688c27
14 Nf6f04c4b6e2b4aa5b14eb4fe493c3e7d
15 Nfcaea71b459243b2a67352a4cf7e018f
16 anzsrc-for:11
17 anzsrc-for:1109
18 schema:author Nfb64e95996784828b6e260c4697cb074
19 schema:citation sg:pub.10.1038/328632a0
20 sg:pub.10.1038/nn.2693
21 sg:pub.10.1038/npp.2015.240
22 sg:pub.10.1038/nrn2093
23 https://doi.org/10.1002/hipo.10005
24 https://doi.org/10.1002/hipo.1071
25 https://doi.org/10.1002/mus.22210
26 https://doi.org/10.1002/syn.20831
27 https://doi.org/10.1016/j.conb.2004.03.017
28 https://doi.org/10.1016/j.neulet.2012.09.014
29 https://doi.org/10.1016/j.neuron.2005.01.010
30 https://doi.org/10.1016/j.neuron.2008.10.050
31 https://doi.org/10.1016/j.neuron.2009.08.014
32 https://doi.org/10.1016/j.neuropharm.2008.06.075
33 https://doi.org/10.1016/j.nlm.2009.09.009
34 https://doi.org/10.1016/j.nlm.2013.07.013
35 https://doi.org/10.1016/j.physbeh.2014.03.005
36 https://doi.org/10.1016/s0006-2952(03)00187-4
37 https://doi.org/10.1016/s0006-3223(00)01008-8
38 https://doi.org/10.1016/s0166-4328(02)00238-3
39 https://doi.org/10.1016/s0304-3940(02)01418-0
40 https://doi.org/10.1016/s0306-4522(01)00301-3
41 https://doi.org/10.1016/s0896-6273(01)00276-8
42 https://doi.org/10.1037/11164-000
43 https://doi.org/10.1037/h0040546
44 https://doi.org/10.1037/h0043788
45 https://doi.org/10.1037/h0046577
46 https://doi.org/10.1073/pnas.0706900104
47 https://doi.org/10.1080/02568540709594622
48 https://doi.org/10.1098/rspb.2014.2516
49 https://doi.org/10.1111/0023-8333.81997008
50 https://doi.org/10.1111/j.1460-9568.2009.07042.x
51 https://doi.org/10.1111/j.1467-9450.2005.00443.x
52 https://doi.org/10.1126/science.281.5380.1185
53 https://doi.org/10.1126/science.3037702
54 https://doi.org/10.1146/annurev.ne.15.030192.002033
55 https://doi.org/10.1152/jn.00217.2004
56 https://doi.org/10.1207/s15326985ep4102_3
57 https://doi.org/10.1212/wnl.56.10.1377
58 https://doi.org/10.1242/jcs.055095
59 https://doi.org/10.12968/bjon.2009.18.10.42485
60 https://doi.org/10.1515/revneuro.2006.17.1-2.111
61 https://doi.org/10.1523/jneurosci.0461-11.2011
62 https://doi.org/10.1523/jneurosci.22-19-08476.2002
63 https://doi.org/10.1523/jneurosci.22-23-10067.2002
64 https://doi.org/10.1523/jneurosci.4970-03.2004
65 https://doi.org/10.1523/jneurosci.5331-09.2010
66 https://doi.org/10.3389/fnins.2013.00053
67 schema:datePublished 2016-11
68 schema:datePublishedReg 2016-11-01
69 schema:description Understanding the mechanisms of memory formation is fundamental to establishing optimal educational practices and restoring cognitive function in brain disease. Here, we show for the first time in a non-primate species, that spatial learning receives a special bonus from self-directed exploration. In contrast, when exploration is escape-oriented, or when the full repertoire of exploratory behaviors is reduced, no learning bonus occurs. These findings permitted the first molecular and cellular examinations into the coupling of exploration to learning. We found elevated expression of neuronal calcium sensor 1 (Ncs1) and dopamine type-2 receptors upon self-directed exploration, in concert with increased neuronal activity in the hippocampal dentate gyrus and area CA3, as well as the nucleus accumbens. We probed further into the learning bonus by developing a point mutant mouse (Ncs1(P144S/P144S)) harboring a destabilized NCS-1 protein, and found this line lacked the equivalent self-directed exploration learning bonus. Acute knock-down of Ncs1 in the hippocampus also decoupled exploration from efficient learning. These results are potentially relevant for augmenting learning and memory in health and disease, and provide the basis for further molecular and circuit analyses in this direction.
70 schema:genre research_article
71 schema:inLanguage en
72 schema:isAccessibleForFree true
73 schema:isPartOf N3cce9d46ff31420cbb16b06599fba96a
74 N8246d9368f27432aa2490446bbf9d21b
75 sg:journal.1045337
76 schema:name Self-directed exploration provides a Ncs1-dependent learning bonus
77 schema:pagination 17697
78 schema:productId Na0dbefef64fb475b93597bae94b59d1a
79 Naa74a67d97714c0fad7e279c81b1dca8
80 Nad05fdce69cd431c948ebc8ff0f314a0
81 Nbc6c9c82bcdd476488fd874ba6dc1e8a
82 Nd3c05d57e11c4f979cd26684ca1ca238
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023628241
84 https://doi.org/10.1038/srep17697
85 schema:sdDatePublished 2019-04-10T18:31
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher N562112b48c984642a70537387bd184e1
88 schema:url http://www.nature.com/srep/2015/151207/srep17697/full/srep17697.html
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N0c4a77f801b44ce1988f81ab12bf1c12 rdf:first sg:person.0702243767.12
93 rdf:rest Ne38b9437600c4e86bad3b3d789515e8f
94 N10c69a4c8fa44c92859aaabe92648234 rdf:first sg:person.011306114245.52
95 rdf:rest rdf:nil
96 N1b4a24a587784c649ebe3ebda610a0b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Nucleus Accumbens
98 rdf:type schema:DefinedTerm
99 N1beb5d6635d24162881debe39144504c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Male
101 rdf:type schema:DefinedTerm
102 N1ef7f025550a4deb938d7881b4158406 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Receptors, Dopamine D2
104 rdf:type schema:DefinedTerm
105 N2a584374b4f0403bbe624a5209a20131 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Exploratory Behavior
107 rdf:type schema:DefinedTerm
108 N2e3b15f47fa64bf59d1d95e894b2965d rdf:first sg:person.0716550245.16
109 rdf:rest Nbe116bda3d714d5faab8d1f592bda390
110 N385432b1a42c4812a840dbc2df43eb9d rdf:first sg:person.01040231156.72
111 rdf:rest N0c4a77f801b44ce1988f81ab12bf1c12
112 N3cce9d46ff31420cbb16b06599fba96a schema:volumeNumber 5
113 rdf:type schema:PublicationVolume
114 N4d42bbe2b4fd409c88045e85a906fb38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Gene Knockdown Techniques
116 rdf:type schema:DefinedTerm
117 N562112b48c984642a70537387bd184e1 schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 N57ced80a7a254b009ccaf148c861a3cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Learning
121 rdf:type schema:DefinedTerm
122 N603621a1e295443f9969e5d6ee0baf1e schema:name Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
123 rdf:type schema:Organization
124 N8233937148ad49afb7fe235102ed17db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Spatial Memory
126 rdf:type schema:DefinedTerm
127 N8246d9368f27432aa2490446bbf9d21b schema:issueNumber 1
128 rdf:type schema:PublicationIssue
129 N97e78efd98b94297ba1f79860ec83d5f rdf:first sg:person.01132720767.15
130 rdf:rest N10c69a4c8fa44c92859aaabe92648234
131 Na0dbefef64fb475b93597bae94b59d1a schema:name pubmed_id
132 schema:value 26639399
133 rdf:type schema:PropertyValue
134 Naa74a67d97714c0fad7e279c81b1dca8 schema:name doi
135 schema:value 10.1038/srep17697
136 rdf:type schema:PropertyValue
137 Nad05fdce69cd431c948ebc8ff0f314a0 schema:name dimensions_id
138 schema:value pub.1023628241
139 rdf:type schema:PropertyValue
140 Nb151d94ec68d49459618635ffe7d0c32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Environment
142 rdf:type schema:DefinedTerm
143 Nbc6c9c82bcdd476488fd874ba6dc1e8a schema:name nlm_unique_id
144 schema:value 101563288
145 rdf:type schema:PropertyValue
146 Nbe116bda3d714d5faab8d1f592bda390 rdf:first sg:person.01111452372.92
147 rdf:rest N97e78efd98b94297ba1f79860ec83d5f
148 Nbf5ae9e8cffe452caa8ce79c1e6850e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Animals
150 rdf:type schema:DefinedTerm
151 Ncd7baad6b442403b86c83e0e2dbcf38d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Neuronal Calcium-Sensor Proteins
153 rdf:type schema:DefinedTerm
154 Nd0f37b4f6400495ba3106f74bafce9fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name CA3 Region, Hippocampal
156 rdf:type schema:DefinedTerm
157 Nd3c05d57e11c4f979cd26684ca1ca238 schema:name readcube_id
158 schema:value 70924c7db1c2babdb09a9ea537636d3e99bfa20a085c7e6694aceb04007aab0d
159 rdf:type schema:PropertyValue
160 Ndfbd97d4ea764ecd9ea102cdf6665677 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Dentate Gyrus
162 rdf:type schema:DefinedTerm
163 Ne38b9437600c4e86bad3b3d789515e8f rdf:first sg:person.01043413110.67
164 rdf:rest N2e3b15f47fa64bf59d1d95e894b2965d
165 Nf0ec2944ad584b448bbac97848688c27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Proto-Oncogene Proteins c-fos
167 rdf:type schema:DefinedTerm
168 Nf6f04c4b6e2b4aa5b14eb4fe493c3e7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Neuropeptides
170 rdf:type schema:DefinedTerm
171 Nfb64e95996784828b6e260c4697cb074 rdf:first sg:person.01014263307.68
172 rdf:rest N385432b1a42c4812a840dbc2df43eb9d
173 Nfcaea71b459243b2a67352a4cf7e018f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Mice, Inbred C57BL
175 rdf:type schema:DefinedTerm
176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical and Health Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
180 schema:name Neurosciences
181 rdf:type schema:DefinedTerm
182 sg:grant.5878326 http://pending.schema.org/fundedItem sg:pub.10.1038/srep17697
183 rdf:type schema:MonetaryGrant
184 sg:grant.6111507 http://pending.schema.org/fundedItem sg:pub.10.1038/srep17697
185 rdf:type schema:MonetaryGrant
186 sg:journal.1045337 schema:issn 2045-2322
187 schema:name Scientific Reports
188 rdf:type schema:Periodical
189 sg:person.01014263307.68 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
190 schema:familyName Mun
191 schema:givenName Ho-Suk
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014263307.68
193 rdf:type schema:Person
194 sg:person.01040231156.72 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
195 schema:familyName Saab
196 schema:givenName Bechara J
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040231156.72
198 rdf:type schema:Person
199 sg:person.01043413110.67 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
200 schema:familyName McGirr
201 schema:givenName Alexander
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043413110.67
203 rdf:type schema:Person
204 sg:person.01111452372.92 schema:affiliation https://www.grid.ac/institutes/grid.7597.c
205 schema:familyName Gondo
206 schema:givenName Yoichi
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111452372.92
208 rdf:type schema:Person
209 sg:person.011306114245.52 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
210 schema:familyName Roder
211 schema:givenName John C
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011306114245.52
213 rdf:type schema:Person
214 sg:person.01132720767.15 schema:affiliation N603621a1e295443f9969e5d6ee0baf1e
215 schema:familyName Georgiou
216 schema:givenName John
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132720767.15
218 rdf:type schema:Person
219 sg:person.0702243767.12 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
220 schema:familyName Ng
221 schema:givenName Enoch
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702243767.12
223 rdf:type schema:Person
224 sg:person.0716550245.16 schema:affiliation https://www.grid.ac/institutes/grid.466471.6
225 schema:familyName Lipina
226 schema:givenName Tatiana V
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716550245.16
228 rdf:type schema:Person
229 sg:pub.10.1038/328632a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021930315
230 https://doi.org/10.1038/328632a0
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/nn.2693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019287546
233 https://doi.org/10.1038/nn.2693
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/npp.2015.240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023331073
236 https://doi.org/10.1038/npp.2015.240
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/nrn2093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037709801
239 https://doi.org/10.1038/nrn2093
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/hipo.10005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036756340
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/hipo.1071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006501164
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/mus.22210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002035217
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/syn.20831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016544382
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.conb.2004.03.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043785216
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.neulet.2012.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013942293
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.neuron.2005.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002955611
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.neuron.2008.10.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043436388
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.neuron.2009.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033355935
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.neuropharm.2008.06.075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024149481
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.nlm.2009.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031475066
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.nlm.2013.07.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043266182
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.physbeh.2014.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053066744
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/s0006-2952(03)00187-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005157864
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/s0006-3223(00)01008-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002876565
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0166-4328(02)00238-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011817633
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0304-3940(02)01418-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013618643
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0306-4522(01)00301-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020259592
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0896-6273(01)00276-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000284162
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1037/11164-000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109386037
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1037/h0040546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042995051
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1037/h0043788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001688369
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1037/h0046577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016337716
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1073/pnas.0706900104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016731921
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1080/02568540709594622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053621150
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1098/rspb.2014.2516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005975628
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1111/0023-8333.81997008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048946530
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1111/j.1460-9568.2009.07042.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033778541
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1111/j.1467-9450.2005.00443.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053073901
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1126/science.281.5380.1185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062562202
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1126/science.3037702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062584475
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1146/annurev.ne.15.030192.002033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028820203
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1152/jn.00217.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041735497
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1207/s15326985ep4102_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002411906
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1212/wnl.56.10.1377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064379259
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1242/jcs.055095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014282539
312 rdf:type schema:CreativeWork
313 https://doi.org/10.12968/bjon.2009.18.10.42485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064791483
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1515/revneuro.2006.17.1-2.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006608081
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1523/jneurosci.0461-11.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040507314
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1523/jneurosci.22-19-08476.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075167137
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1523/jneurosci.22-23-10067.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075195958
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1523/jneurosci.4970-03.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045639203
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1523/jneurosci.5331-09.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043597074
326 rdf:type schema:CreativeWork
327 https://doi.org/10.3389/fnins.2013.00053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043648127
328 rdf:type schema:CreativeWork
329 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
330 schema:name Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.
331 Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada.
332 Institute of Medical Science, University of Toronto, Toronto, ON, M5S 1A8, Canada.
333 Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
336 schema:name Department of Psychiatry, University of British Columbia, Vancouver, BC, V6T 2A1, Canada.
337 Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
338 rdf:type schema:Organization
339 https://www.grid.ac/institutes/grid.466471.6 schema:alternateName Research Institute of Physiology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Medical Sciences
340 schema:name Federal State Budgetary Scientific Institution, Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, 630117, Russia.
341 rdf:type schema:Organization
342 https://www.grid.ac/institutes/grid.7400.3 schema:alternateName University of Zurich
343 schema:name Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.
344 Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
345 Neuroscience Center Zurich, Zurich, CH-8057, Switzerland.
346 Preclinical Laboratory for Translational Research into Affective Disorders, University of Zurich Hospital for Psychiatry, August-Forel-Str 7, CH-8008, Zurich, Switzerland.
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.7597.c schema:alternateName RIKEN
349 schema:name Mutagenesis and Genomics Team, RIKEN BioResource Center, Tsukuba 305-0074, Japan.
350 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...