Position-specific automated processing of V3 env ultra-deep pyrosequencing data for predicting HIV-1 tropism View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Nicolas Jeanne, Adrien Saliou, Romain Carcenac, Caroline Lefebvre, Martine Dubois, Michelle Cazabat, Florence Nicot, Claire Loiseau, Stéphanie Raymond, Jacques Izopet, Pierre Delobel

ABSTRACT

HIV-1 coreceptor usage must be accurately determined before starting CCR5 antagonist-based treatment as the presence of undetected minor CXCR4-using variants can cause subsequent virological failure. Ultra-deep pyrosequencing of HIV-1 V3 env allows to detect low levels of CXCR4-using variants that current genotypic approaches miss. However, the computation of the mass of sequence data and the need to identify true minor variants while excluding artifactual sequences generated during amplification and ultra-deep pyrosequencing is rate-limiting. Arbitrary fixed cut-offs below which minor variants are discarded are currently used but the errors generated during ultra-deep pyrosequencing are sequence-dependant rather than random. We have developed an automated processing of HIV-1 V3 env ultra-deep pyrosequencing data that uses biological filters to discard artifactual or non-functional V3 sequences followed by statistical filters to determine position-specific sensitivity thresholds, rather than arbitrary fixed cut-offs. It allows to retain authentic sequences with point mutations at V3 positions of interest and discard artifactual ones with accurate sensitivity thresholds. More... »

PAGES

16944

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep16944

DOI

http://dx.doi.org/10.1038/srep16944

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049097180

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26585833


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclohexanes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Envelope Protein gp120", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Fusion Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "High-Throughput Nucleotide Sequencing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Host-Pathogen Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Point Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, CCR5", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, CXCR4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Triazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Tropism", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Purpan", 
          "id": "https://www.grid.ac/institutes/grid.414282.9", 
          "name": [
            "Laboratoire de Virologie, H\u00f4pital Purpan, Toulouse, F-31300 France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeanne", 
        "givenName": "Nicolas", 
        "id": "sg:person.01370435143.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370435143.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Purpan", 
          "id": "https://www.grid.ac/institutes/grid.414282.9", 
          "name": [
            "Laboratoire de Virologie, H\u00f4pital Purpan, Toulouse, F-31300 France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saliou", 
        "givenName": "Adrien", 
        "id": "sg:person.01053766742.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053766742.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Purpan", 
          "id": "https://www.grid.ac/institutes/grid.414282.9", 
          "name": [
            "Laboratoire de Virologie, H\u00f4pital Purpan, Toulouse, F-31300 France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carcenac", 
        "givenName": "Romain", 
        "id": "sg:person.0645334303.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645334303.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Purpan", 
          "id": "https://www.grid.ac/institutes/grid.414282.9", 
          "name": [
            "Laboratoire de Virologie, H\u00f4pital Purpan, Toulouse, F-31300 France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lefebvre", 
        "givenName": "Caroline", 
        "id": "sg:person.0713447503.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713447503.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u00e9l\u00e9gation Midi-Pyr\u00e9n\u00e9es, Limousin", 
          "id": "https://www.grid.ac/institutes/grid.457379.b", 
          "name": [
            "Laboratoire de Virologie, H\u00f4pital Purpan, Toulouse, F-31300 France.", 
            "INSERM, UMR1043, Toulouse, F-31300 France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dubois", 
        "givenName": "Martine", 
        "id": "sg:person.01101047437.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101047437.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u00e9l\u00e9gation Midi-Pyr\u00e9n\u00e9es, Limousin", 
          "id": "https://www.grid.ac/institutes/grid.457379.b", 
          "name": [
            "Laboratoire de Virologie, H\u00f4pital Purpan, Toulouse, F-31300 France.", 
            "INSERM, UMR1043, Toulouse, F-31300 France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cazabat", 
        "givenName": "Michelle", 
        "id": "sg:person.0600122341.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600122341.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u00e9l\u00e9gation Midi-Pyr\u00e9n\u00e9es, Limousin", 
          "id": "https://www.grid.ac/institutes/grid.457379.b", 
          "name": [
            "Laboratoire de Virologie, H\u00f4pital Purpan, Toulouse, F-31300 France.", 
            "INSERM, UMR1043, Toulouse, F-31300 France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nicot", 
        "givenName": "Florence", 
        "id": "sg:person.01102612747.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102612747.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u00e9l\u00e9gation Midi-Pyr\u00e9n\u00e9es, Limousin", 
          "id": "https://www.grid.ac/institutes/grid.457379.b", 
          "name": [
            "INSERM, UMR1043, Toulouse, F-31300 France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loiseau", 
        "givenName": "Claire", 
        "id": "sg:person.01256332615.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256332615.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paul Sabatier University", 
          "id": "https://www.grid.ac/institutes/grid.15781.3a", 
          "name": [
            "Laboratoire de Virologie, H\u00f4pital Purpan, Toulouse, F-31300 France.", 
            "INSERM, UMR1043, Toulouse, F-31300 France.", 
            "Universit\u00e9 Toulouse III Paul Sabatier, Toulouse, F-31000 France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raymond", 
        "givenName": "St\u00e9phanie", 
        "id": "sg:person.01224565466.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224565466.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paul Sabatier University", 
          "id": "https://www.grid.ac/institutes/grid.15781.3a", 
          "name": [
            "Laboratoire de Virologie, H\u00f4pital Purpan, Toulouse, F-31300 France.", 
            "INSERM, UMR1043, Toulouse, F-31300 France.", 
            "Universit\u00e9 Toulouse III Paul Sabatier, Toulouse, F-31000 France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Izopet", 
        "givenName": "Jacques", 
        "id": "sg:person.0660147046.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660147046.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Purpan", 
          "id": "https://www.grid.ac/institutes/grid.414282.9", 
          "name": [
            "INSERM, UMR1043, Toulouse, F-31300 France.", 
            "Universit\u00e9 Toulouse III Paul Sabatier, Toulouse, F-31000 France.", 
            "Service des Maladies Infectieuses et Tropicales, H\u00f4pital Purpan, Toulouse, F-31300 France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delobel", 
        "givenName": "Pierre", 
        "id": "sg:person.01062266756.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062266756.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jcv.2009.11.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000214786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-12-245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001107421", 
          "https://doi.org/10.1186/1471-2164-12-245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00965-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001652852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0803154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002186294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.02328-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002919610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181d0558f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003879932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181d0558f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003879932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181d0558f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003879932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181d0558f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003879932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/coh.0b013e328356e9da", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004257616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/coh.0b013e328356e9da", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004257616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jviromet.2010.06.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004422165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkq379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005954414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkq379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005954414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1002106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011004447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/coh.0b013e328356f6d7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014452306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/coh.0b013e328356f6d7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014452306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0076502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018647424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-6405-7-41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018766404", 
          "https://doi.org/10.1186/1742-6405-7-41"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0074249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021254595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.00091-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022409118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022594389", 
          "https://doi.org/10.1038/nbt1371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.77.24.13376-13388.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023762429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/648090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024293976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32830ebcd4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024538449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32830ebcd4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024538449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0046334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025693119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep08056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025800612", 
          "https://doi.org/10.1038/srep08056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e3282ef81ea", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025891554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e3282ef81ea", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025891554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkq535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026721626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832b4399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028860284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832b4399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028860284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832b4399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028860284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/381667a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029523781", 
          "https://doi.org/10.1038/381667a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-6405-7-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032095104", 
          "https://doi.org/10.1186/1742-6405-7-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e328343489e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033785018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e328343489e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033785018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.02090-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035460633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832fd2e1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036396969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832fd2e1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036396969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832fd2e1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036396969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.75.1.251-259.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036676679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.2012.0338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038180448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0803152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040477846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/34571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042683516", 
          "https://doi.org/10.1038/34571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/34571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042683516", 
          "https://doi.org/10.1038/34571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.00853-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043281588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-0691.2010.03350.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043743558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/650697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044114915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-4690-8-56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044696697", 
          "https://doi.org/10.1186/1742-4690-8-56"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0005683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048242989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2011.375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048802497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0070388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049244655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.49.11.4721-4732.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050138940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/381661a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053562821", 
          "https://doi.org/10.1038/381661a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1905842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062512952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.272.5270.1955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062553455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076213841", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076981417", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077519581", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "HIV-1 coreceptor usage must be accurately determined before starting CCR5 antagonist-based treatment as the presence of undetected minor CXCR4-using variants can cause subsequent virological failure. Ultra-deep pyrosequencing of HIV-1 V3 env allows to detect low levels of CXCR4-using variants that current genotypic approaches miss. However, the computation of the mass of sequence data and the need to identify true minor variants while excluding artifactual sequences generated during amplification and ultra-deep pyrosequencing is rate-limiting. Arbitrary fixed cut-offs below which minor variants are discarded are currently used but the errors generated during ultra-deep pyrosequencing are sequence-dependant rather than random. We have developed an automated processing of HIV-1 V3 env ultra-deep pyrosequencing data that uses biological filters to discard artifactual or non-functional V3 sequences followed by statistical filters to determine position-specific sensitivity thresholds, rather than arbitrary fixed cut-offs. It allows to retain authentic sequences with point mutations at V3 positions of interest and discard artifactual ones with accurate sensitivity thresholds. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep16944", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "Position-specific automated processing of V3 env ultra-deep pyrosequencing data for predicting HIV-1 tropism", 
    "pagination": "16944", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e9e459aa21b9a50e92677add8d8cdec3a0827b5616a13e05a82b107ced654492"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26585833"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep16944"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049097180"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep16944", 
      "https://app.dimensions.ai/details/publication/pub.1049097180"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2015/151120/srep16944/full/srep16944.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep16944'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep16944'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep16944'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep16944'


 

This table displays all metadata directly associated to this object as RDF triples.

373 TRIPLES      21 PREDICATES      95 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep16944 schema:about N10488a57c94e434f8dbf218ce33619ba
2 N25e84bd5250f418db413336d6f701f20
3 N2ba36e436c5046e8bb92b0389a2f1c0a
4 N48694ea6515a42cba57510d01320c2db
5 N4a706adf196e48abafbcc8fe074580a8
6 N66915bf6bcbc495aa350cb97435c1e25
7 N6c51cec99e4642a484679b2afef56340
8 N6f90e566a7de45bfadd8b0b21a81caf6
9 N7e45ed7d3f9340c6b25fa109ab5232e5
10 N8ee1d15816ef4836876c34fc2481b883
11 Na774f9de371f41d99a8145fa996eccd8
12 Nc318b616f5d6457db16dfe00eae0affe
13 Nc68e858c832940b8b11f5dfc1090e991
14 Nd4d05a2ad2ed4cb5b629e8e062c2fb93
15 Ndc76f757f4284561ba86469d3705f489
16 Ne2c103d976e34c4b955337161377fb4d
17 Nf0c3c05efbbe45c18c562f7755f90252
18 Nf2f66d9d465b43209cba95863805f6fd
19 Nfae62fd706854892b16ae37509b69627
20 anzsrc-for:11
21 anzsrc-for:1103
22 schema:author N5ec9dab6b96a4a0cb823acdea8fdd364
23 schema:citation sg:pub.10.1038/34571
24 sg:pub.10.1038/381661a0
25 sg:pub.10.1038/381667a0
26 sg:pub.10.1038/nbt1371
27 sg:pub.10.1038/srep08056
28 sg:pub.10.1186/1471-2164-12-245
29 sg:pub.10.1186/1742-4690-8-56
30 sg:pub.10.1186/1742-6405-7-4
31 sg:pub.10.1186/1742-6405-7-41
32 https://app.dimensions.ai/details/publication/pub.1076213841
33 https://app.dimensions.ai/details/publication/pub.1076981417
34 https://app.dimensions.ai/details/publication/pub.1077519581
35 https://doi.org/10.1001/jama.2011.375
36 https://doi.org/10.1016/j.jcv.2009.11.018
37 https://doi.org/10.1016/j.jviromet.2010.06.012
38 https://doi.org/10.1056/nejmoa0803152
39 https://doi.org/10.1056/nejmoa0803154
40 https://doi.org/10.1086/648090
41 https://doi.org/10.1086/650697
42 https://doi.org/10.1089/aid.2012.0338
43 https://doi.org/10.1093/jac/dkq379
44 https://doi.org/10.1093/jac/dkq535
45 https://doi.org/10.1097/coh.0b013e328356e9da
46 https://doi.org/10.1097/coh.0b013e328356f6d7
47 https://doi.org/10.1097/qad.0b013e3282ef81ea
48 https://doi.org/10.1097/qad.0b013e32830ebcd4
49 https://doi.org/10.1097/qad.0b013e32832b4399
50 https://doi.org/10.1097/qad.0b013e32832fd2e1
51 https://doi.org/10.1097/qad.0b013e328343489e
52 https://doi.org/10.1097/qai.0b013e3181d0558f
53 https://doi.org/10.1111/j.1469-0691.2010.03350.x
54 https://doi.org/10.1126/science.1905842
55 https://doi.org/10.1126/science.272.5270.1955
56 https://doi.org/10.1128/aac.00091-11
57 https://doi.org/10.1128/aac.00853-06
58 https://doi.org/10.1128/aac.49.11.4721-4732.2005
59 https://doi.org/10.1128/jcm.02090-06
60 https://doi.org/10.1128/jcm.02328-12
61 https://doi.org/10.1128/jvi.00965-06
62 https://doi.org/10.1128/jvi.75.1.251-259.2001
63 https://doi.org/10.1128/jvi.77.24.13376-13388.2003
64 https://doi.org/10.1371/journal.pone.0005683
65 https://doi.org/10.1371/journal.pone.0046334
66 https://doi.org/10.1371/journal.pone.0070388
67 https://doi.org/10.1371/journal.pone.0074249
68 https://doi.org/10.1371/journal.pone.0076502
69 https://doi.org/10.1371/journal.ppat.1002106
70 schema:datePublished 2015-12
71 schema:datePublishedReg 2015-12-01
72 schema:description HIV-1 coreceptor usage must be accurately determined before starting CCR5 antagonist-based treatment as the presence of undetected minor CXCR4-using variants can cause subsequent virological failure. Ultra-deep pyrosequencing of HIV-1 V3 env allows to detect low levels of CXCR4-using variants that current genotypic approaches miss. However, the computation of the mass of sequence data and the need to identify true minor variants while excluding artifactual sequences generated during amplification and ultra-deep pyrosequencing is rate-limiting. Arbitrary fixed cut-offs below which minor variants are discarded are currently used but the errors generated during ultra-deep pyrosequencing are sequence-dependant rather than random. We have developed an automated processing of HIV-1 V3 env ultra-deep pyrosequencing data that uses biological filters to discard artifactual or non-functional V3 sequences followed by statistical filters to determine position-specific sensitivity thresholds, rather than arbitrary fixed cut-offs. It allows to retain authentic sequences with point mutations at V3 positions of interest and discard artifactual ones with accurate sensitivity thresholds.
73 schema:genre research_article
74 schema:inLanguage en
75 schema:isAccessibleForFree true
76 schema:isPartOf N0e3b6b0bcbc74459a68023b0b32e8bee
77 N719362b1d48a4fa0bfe5ee185333fc48
78 sg:journal.1045337
79 schema:name Position-specific automated processing of V3 env ultra-deep pyrosequencing data for predicting HIV-1 tropism
80 schema:pagination 16944
81 schema:productId N11f85b9888f14624bc1398ad1d07ffd3
82 N4c8de175184941cc8cac41b420093411
83 N8b8d145c857843398d0b79e2692cc0d9
84 Nae229c17827049b587f99c7f087eb4ed
85 Nd603e725965b4141ba9fa800b16bde06
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049097180
87 https://doi.org/10.1038/srep16944
88 schema:sdDatePublished 2019-04-11T00:04
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher N56fb670028bb422da7938936a654a79a
91 schema:url http://www.nature.com/srep/2015/151120/srep16944/full/srep16944.html
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N04dda4fb42a345baadc922896a8f433b rdf:first sg:person.0600122341.57
96 rdf:rest Nc639b52619864d689dd9b090507536c0
97 N0e3b6b0bcbc74459a68023b0b32e8bee schema:issueNumber 1
98 rdf:type schema:PublicationIssue
99 N10488a57c94e434f8dbf218ce33619ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Molecular Sequence Data
101 rdf:type schema:DefinedTerm
102 N11f85b9888f14624bc1398ad1d07ffd3 schema:name pubmed_id
103 schema:value 26585833
104 rdf:type schema:PropertyValue
105 N25e84bd5250f418db413336d6f701f20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Genotype
107 rdf:type schema:DefinedTerm
108 N2b1bbf28fb3c46b787db171b14eb5613 rdf:first sg:person.01224565466.68
109 rdf:rest Nd778fb77f7d249ebb4d4d2e2747c85d2
110 N2ba36e436c5046e8bb92b0389a2f1c0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Amino Acid Sequence
112 rdf:type schema:DefinedTerm
113 N2e30631a672b4f18b34265c8b59b7784 rdf:first sg:person.01256332615.45
114 rdf:rest N2b1bbf28fb3c46b787db171b14eb5613
115 N48694ea6515a42cba57510d01320c2db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Point Mutation
117 rdf:type schema:DefinedTerm
118 N4a706adf196e48abafbcc8fe074580a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name HIV Fusion Inhibitors
120 rdf:type schema:DefinedTerm
121 N4c8de175184941cc8cac41b420093411 schema:name doi
122 schema:value 10.1038/srep16944
123 rdf:type schema:PropertyValue
124 N56fb670028bb422da7938936a654a79a schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N5ec9dab6b96a4a0cb823acdea8fdd364 rdf:first sg:person.01370435143.19
127 rdf:rest N7962b76b8b4b44a6b3bcb9be2a3c153f
128 N66915bf6bcbc495aa350cb97435c1e25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name HIV-1
130 rdf:type schema:DefinedTerm
131 N6c51cec99e4642a484679b2afef56340 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Receptors, CXCR4
133 rdf:type schema:DefinedTerm
134 N6d00821b030f499c8fe920a62393d89f rdf:first sg:person.01062266756.00
135 rdf:rest rdf:nil
136 N6f90e566a7de45bfadd8b0b21a81caf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Cyclohexanes
138 rdf:type schema:DefinedTerm
139 N719362b1d48a4fa0bfe5ee185333fc48 schema:volumeNumber 5
140 rdf:type schema:PublicationVolume
141 N761462a08c9640a1a5927e419c4c1951 rdf:first sg:person.01101047437.90
142 rdf:rest N04dda4fb42a345baadc922896a8f433b
143 N7962b76b8b4b44a6b3bcb9be2a3c153f rdf:first sg:person.01053766742.76
144 rdf:rest Naa754af0b87e48e6838773ded33a052f
145 N7e45ed7d3f9340c6b25fa109ab5232e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name HIV Envelope Protein gp120
147 rdf:type schema:DefinedTerm
148 N8b8d145c857843398d0b79e2692cc0d9 schema:name nlm_unique_id
149 schema:value 101563288
150 rdf:type schema:PropertyValue
151 N8ee1d15816ef4836876c34fc2481b883 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Phenotype
153 rdf:type schema:DefinedTerm
154 Na774f9de371f41d99a8145fa996eccd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Reproducibility of Results
156 rdf:type schema:DefinedTerm
157 Naa754af0b87e48e6838773ded33a052f rdf:first sg:person.0645334303.49
158 rdf:rest Nd2ee70523532414abbcf9d8291fb39fc
159 Nae229c17827049b587f99c7f087eb4ed schema:name readcube_id
160 schema:value e9e459aa21b9a50e92677add8d8cdec3a0827b5616a13e05a82b107ced654492
161 rdf:type schema:PropertyValue
162 Nc318b616f5d6457db16dfe00eae0affe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Peptide Fragments
164 rdf:type schema:DefinedTerm
165 Nc639b52619864d689dd9b090507536c0 rdf:first sg:person.01102612747.51
166 rdf:rest N2e30631a672b4f18b34265c8b59b7784
167 Nc68e858c832940b8b11f5dfc1090e991 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Humans
169 rdf:type schema:DefinedTerm
170 Nd2ee70523532414abbcf9d8291fb39fc rdf:first sg:person.0713447503.09
171 rdf:rest N761462a08c9640a1a5927e419c4c1951
172 Nd4d05a2ad2ed4cb5b629e8e062c2fb93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name High-Throughput Nucleotide Sequencing
174 rdf:type schema:DefinedTerm
175 Nd603e725965b4141ba9fa800b16bde06 schema:name dimensions_id
176 schema:value pub.1049097180
177 rdf:type schema:PropertyValue
178 Nd778fb77f7d249ebb4d4d2e2747c85d2 rdf:first sg:person.0660147046.43
179 rdf:rest N6d00821b030f499c8fe920a62393d89f
180 Ndc76f757f4284561ba86469d3705f489 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Receptors, CCR5
182 rdf:type schema:DefinedTerm
183 Ne2c103d976e34c4b955337161377fb4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name HIV Infections
185 rdf:type schema:DefinedTerm
186 Nf0c3c05efbbe45c18c562f7755f90252 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Viral Tropism
188 rdf:type schema:DefinedTerm
189 Nf2f66d9d465b43209cba95863805f6fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Host-Pathogen Interactions
191 rdf:type schema:DefinedTerm
192 Nfae62fd706854892b16ae37509b69627 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Triazoles
194 rdf:type schema:DefinedTerm
195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
196 schema:name Medical and Health Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
199 schema:name Clinical Sciences
200 rdf:type schema:DefinedTerm
201 sg:journal.1045337 schema:issn 2045-2322
202 schema:name Scientific Reports
203 rdf:type schema:Periodical
204 sg:person.01053766742.76 schema:affiliation https://www.grid.ac/institutes/grid.414282.9
205 schema:familyName Saliou
206 schema:givenName Adrien
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053766742.76
208 rdf:type schema:Person
209 sg:person.01062266756.00 schema:affiliation https://www.grid.ac/institutes/grid.414282.9
210 schema:familyName Delobel
211 schema:givenName Pierre
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062266756.00
213 rdf:type schema:Person
214 sg:person.01101047437.90 schema:affiliation https://www.grid.ac/institutes/grid.457379.b
215 schema:familyName Dubois
216 schema:givenName Martine
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101047437.90
218 rdf:type schema:Person
219 sg:person.01102612747.51 schema:affiliation https://www.grid.ac/institutes/grid.457379.b
220 schema:familyName Nicot
221 schema:givenName Florence
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102612747.51
223 rdf:type schema:Person
224 sg:person.01224565466.68 schema:affiliation https://www.grid.ac/institutes/grid.15781.3a
225 schema:familyName Raymond
226 schema:givenName Stéphanie
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224565466.68
228 rdf:type schema:Person
229 sg:person.01256332615.45 schema:affiliation https://www.grid.ac/institutes/grid.457379.b
230 schema:familyName Loiseau
231 schema:givenName Claire
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256332615.45
233 rdf:type schema:Person
234 sg:person.01370435143.19 schema:affiliation https://www.grid.ac/institutes/grid.414282.9
235 schema:familyName Jeanne
236 schema:givenName Nicolas
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370435143.19
238 rdf:type schema:Person
239 sg:person.0600122341.57 schema:affiliation https://www.grid.ac/institutes/grid.457379.b
240 schema:familyName Cazabat
241 schema:givenName Michelle
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600122341.57
243 rdf:type schema:Person
244 sg:person.0645334303.49 schema:affiliation https://www.grid.ac/institutes/grid.414282.9
245 schema:familyName Carcenac
246 schema:givenName Romain
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645334303.49
248 rdf:type schema:Person
249 sg:person.0660147046.43 schema:affiliation https://www.grid.ac/institutes/grid.15781.3a
250 schema:familyName Izopet
251 schema:givenName Jacques
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660147046.43
253 rdf:type schema:Person
254 sg:person.0713447503.09 schema:affiliation https://www.grid.ac/institutes/grid.414282.9
255 schema:familyName Lefebvre
256 schema:givenName Caroline
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713447503.09
258 rdf:type schema:Person
259 sg:pub.10.1038/34571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042683516
260 https://doi.org/10.1038/34571
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/381661a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053562821
263 https://doi.org/10.1038/381661a0
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/381667a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029523781
266 https://doi.org/10.1038/381667a0
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/nbt1371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022594389
269 https://doi.org/10.1038/nbt1371
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/srep08056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025800612
272 https://doi.org/10.1038/srep08056
273 rdf:type schema:CreativeWork
274 sg:pub.10.1186/1471-2164-12-245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001107421
275 https://doi.org/10.1186/1471-2164-12-245
276 rdf:type schema:CreativeWork
277 sg:pub.10.1186/1742-4690-8-56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044696697
278 https://doi.org/10.1186/1742-4690-8-56
279 rdf:type schema:CreativeWork
280 sg:pub.10.1186/1742-6405-7-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032095104
281 https://doi.org/10.1186/1742-6405-7-4
282 rdf:type schema:CreativeWork
283 sg:pub.10.1186/1742-6405-7-41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018766404
284 https://doi.org/10.1186/1742-6405-7-41
285 rdf:type schema:CreativeWork
286 https://app.dimensions.ai/details/publication/pub.1076213841 schema:CreativeWork
287 https://app.dimensions.ai/details/publication/pub.1076981417 schema:CreativeWork
288 https://app.dimensions.ai/details/publication/pub.1077519581 schema:CreativeWork
289 https://doi.org/10.1001/jama.2011.375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048802497
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.jcv.2009.11.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000214786
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.jviromet.2010.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004422165
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1056/nejmoa0803152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040477846
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1056/nejmoa0803154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002186294
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1086/648090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024293976
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1086/650697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044114915
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1089/aid.2012.0338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038180448
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1093/jac/dkq379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005954414
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1093/jac/dkq535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026721626
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1097/coh.0b013e328356e9da schema:sameAs https://app.dimensions.ai/details/publication/pub.1004257616
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1097/coh.0b013e328356f6d7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014452306
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1097/qad.0b013e3282ef81ea schema:sameAs https://app.dimensions.ai/details/publication/pub.1025891554
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1097/qad.0b013e32830ebcd4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024538449
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1097/qad.0b013e32832b4399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028860284
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1097/qad.0b013e32832fd2e1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036396969
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1097/qad.0b013e328343489e schema:sameAs https://app.dimensions.ai/details/publication/pub.1033785018
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1097/qai.0b013e3181d0558f schema:sameAs https://app.dimensions.ai/details/publication/pub.1003879932
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1111/j.1469-0691.2010.03350.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043743558
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1126/science.1905842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062512952
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1126/science.272.5270.1955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062553455
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1128/aac.00091-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022409118
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1128/aac.00853-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043281588
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1128/aac.49.11.4721-4732.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050138940
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1128/jcm.02090-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035460633
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1128/jcm.02328-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002919610
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1128/jvi.00965-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001652852
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1128/jvi.75.1.251-259.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036676679
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1128/jvi.77.24.13376-13388.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023762429
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1371/journal.pone.0005683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048242989
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1371/journal.pone.0046334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025693119
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1371/journal.pone.0070388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049244655
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1371/journal.pone.0074249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021254595
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1371/journal.pone.0076502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018647424
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1371/journal.ppat.1002106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011004447
358 rdf:type schema:CreativeWork
359 https://www.grid.ac/institutes/grid.15781.3a schema:alternateName Paul Sabatier University
360 schema:name INSERM, UMR1043, Toulouse, F-31300 France.
361 Laboratoire de Virologie, Hôpital Purpan, Toulouse, F-31300 France.
362 Université Toulouse III Paul Sabatier, Toulouse, F-31000 France.
363 rdf:type schema:Organization
364 https://www.grid.ac/institutes/grid.414282.9 schema:alternateName Hôpital Purpan
365 schema:name INSERM, UMR1043, Toulouse, F-31300 France.
366 Laboratoire de Virologie, Hôpital Purpan, Toulouse, F-31300 France.
367 Service des Maladies Infectieuses et Tropicales, Hôpital Purpan, Toulouse, F-31300 France.
368 Université Toulouse III Paul Sabatier, Toulouse, F-31000 France.
369 rdf:type schema:Organization
370 https://www.grid.ac/institutes/grid.457379.b schema:alternateName Délégation Midi-Pyrénées, Limousin
371 schema:name INSERM, UMR1043, Toulouse, F-31300 France.
372 Laboratoire de Virologie, Hôpital Purpan, Toulouse, F-31300 France.
373 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...