Electric Ablation with Irreversible Electroporation (IRE) in Vital Hepatic Structures and Follow-up Investigation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-11-09

AUTHORS

Xinhua Chen, Zhigang Ren, Tongyin Zhu, Xiongxin Zhang, Zhiyi Peng, Haiyang Xie, Lin Zhou, Shengyong Yin, Junhui Sun, Shusen Zheng

ABSTRACT

Irreversible electroporation (IRE) with microsecond-pulsed electric fields (μsPEFs) can effectively ablate hepatocellular carcinomas in animal models. This preclinical study evaluates the feasibility and safety of IRE on porcine livers. Altogether, 10 pigs were included. Computed tomography (CT) was used to guide two-needle electrodes that were inserted near the hilus hepatis and gall bladder. Animals were followed-up at 2 hours and at 2, 7 and 14 days post-treatment. During and after μsPEF ablation, electrocardiographs found no cardiovascular events and contrast CT found no portal vein thrombosis. There was necrosis in the ablation zone. Mild cystic oedema around the gall bladder was found 2 hours post-treatment. Pathological studies showed extensive cell death. There was no large vessel damage, but there was mild endothelial damage in some small vessels. Follow-up liver function tests and routine blood tests showed immediate liver function damage and recovery from the damage, which correlated to the pathological changes. These results indicate that μsPEF ablation affects liver tissue and is less effective in vessels, which enable μsPEFs to ablate central tumour lesions close to the hilus hepatis and near large vessels and bile ducts, removing some of the limitations and contraindications of conventional thermal ablation. More... »

PAGES

16233

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep16233

DOI

http://dx.doi.org/10.1038/srep16233

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000298594

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26549662


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29 schema:description Irreversible electroporation (IRE) with microsecond-pulsed electric fields (μsPEFs) can effectively ablate hepatocellular carcinomas in animal models. This preclinical study evaluates the feasibility and safety of IRE on porcine livers. Altogether, 10 pigs were included. Computed tomography (CT) was used to guide two-needle electrodes that were inserted near the hilus hepatis and gall bladder. Animals were followed-up at 2 hours and at 2, 7 and 14 days post-treatment. During and after μsPEF ablation, electrocardiographs found no cardiovascular events and contrast CT found no portal vein thrombosis. There was necrosis in the ablation zone. Mild cystic oedema around the gall bladder was found 2 hours post-treatment. Pathological studies showed extensive cell death. There was no large vessel damage, but there was mild endothelial damage in some small vessels. Follow-up liver function tests and routine blood tests showed immediate liver function damage and recovery from the damage, which correlated to the pathological changes. These results indicate that μsPEF ablation affects liver tissue and is less effective in vessels, which enable μsPEFs to ablate central tumour lesions close to the hilus hepatis and near large vessels and bile ducts, removing some of the limitations and contraindications of conventional thermal ablation.
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37 ablation zone
38 animal models
39 animals
40 bile duct
41 bladder
42 blood tests
43 carcinoma
44 cardiovascular events
45 cell death
46 changes
47 computed tomography
48 contraindications
49 conventional thermal ablation
50 cystic edema
51 damage
52 days
53 death
54 duct
55 edema
56 electric ablation
57 electric field
58 electrocardiograph
59 electrode
60 electroporation
61 endothelial damage
62 events
63 extensive cell death
64 feasibility
65 field
66 follow
67 function damage
68 function tests
69 gall bladder
70 hepatic structure
71 hepatis
72 hepatocellular carcinoma
73 hilus hepatis
74 hours
75 investigation
76 irreversible electroporation
77 large vessel damage
78 large vessels
79 lesions
80 limitations
81 liver
82 liver function damage
83 liver function tests
84 liver tissue
85 model
86 necrosis
87 pathological changes
88 pathological studies
89 pigs
90 porcine liver
91 portal vein thrombosis
92 preclinical studies
93 recovery
94 results
95 routine blood tests
96 safety
97 safety of IRE
98 small vessels
99 structure
100 study
101 test
102 thermal ablation
103 thrombosis
104 tissue
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106 tumor lesions
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