Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Wei Liu, Shukuan Ling, Weijia Sun, Tong Liu, Yuheng Li, Guohui Zhong, Dingsheng Zhao, Pengfei Zhang, Jinping Song, Xiaoyan Jin, Zi Xu, Hailin Song, Qi Li, Shujuan Liu, Meng Chai, Qinyi Dai, Yi He, Zhanming Fan, Yu Jie Zhou, Yingxian Li

ABSTRACT

The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC), and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary artery disease (CAD) were characterized with coronary artery calcium score (CACS) from cardiac computed tomography (CT). We analyzed plasma miRNA levels of clinical matched 11 CAC (CACS > 100) and 6 non-CAC (CACS = 0) subjects by microarray profile. Microarray analysis identified 34 differentially expressed miRNAs between CAC and non CAC groups. Eight miRNAs (miR-223, miR-3135b, miR-133a-3p, miR-2861, miR-134, miR-191-3p, miR-3679-5p, miR-1229 in CAC patients) were significantly increased in CAC plasma in an independent clinical matched cohort. Four miRNAs (miR-2861, 134, 1229 and 3135b) were correlated with the degree of CAC. Validation test in angiographic cohort showed that miR-134, miR-3135b and miR-2861 were significantly changed in patients with obstructive CAD . We identified three significantly upregulated circulating miRNAs (miR-134, miR-3135b and 2861) correlated with CAC while detected obstructive coronary disease in symptomatic patients. More... »

PAGES

16099

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep16099

DOI

http://dx.doi.org/10.1038/srep16099

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043849334

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26537670


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