Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10-23

AUTHORS

Hyo Jung Seo, Sang Hwan Nam, Hyung-Jun Im, Ji-yong Park, Ji Youn Lee, Byeongjun Yoo, Yun-Sang Lee, Jae Min Jeong, Taeghwan Hyeon, Ji Who Kim, Jae Sung Lee, In-Jin Jang, Joo-Youn Cho, Do Won Hwang, Yung Doug Suh, Dong Soo Lee

ABSTRACT

In the field of nanomedicine, long term accumulation of nanoparticles (NPs) in the mononuclear phagocyte system (MPS) such as liver is the major hurdle in clinical translation. On the other hand, NPs could be excreted via hepatobiliary excretion pathway without overt tissue toxicity. Therefore, it is critical to develop NPs that show favorable excretion property. Herein, we demonstrated that micelle encapsulated 64Cu-labeled upconverting nanoparticles (micelle encapsulated 64Cu-NOTA-UCNPs) showed substantial hepatobiliary excretion by in vivo positron emission tomography (PET) and also upconversion luminescence imaging (ULI). Ex vivo biodistribution study reinforced the imaging results by showing clearance of 84% of initial hepatic uptake in 72 hours. Hepatobiliary excretion of the UCNPs was also verified by transmission electron microscopy (TEM) examination. Micelle encapsulated 64Cu-NOTA-UCNPs could be an optimal bimodal imaging agent owing to quantifiability of 64Cu, ability of in vivo/ex vivo ULI and good hepatobiliary excretion property. More... »

PAGES

15685

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep15685

DOI

http://dx.doi.org/10.1038/srep15685

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013419289

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26494465


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1007", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Nanotechnology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biliary Tract", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Micelles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nanoparticles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron-Emission Tomography", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea", 
            "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seo", 
        "givenName": "Hyo Jung", 
        "id": "sg:person.0617104664.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617104664.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory for Advanced Molecular Probing (LAMP), Research Center for Convergence Nanotechnology, Korea Research Institute of Chemical Technology, Daejeon, Korea", 
          "id": "http://www.grid.ac/institutes/grid.29869.3c", 
          "name": [
            "Laboratory for Advanced Molecular Probing (LAMP), Research Center for Convergence Nanotechnology, Korea Research Institute of Chemical Technology, Daejeon, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nam", 
        "givenName": "Sang Hwan", 
        "id": "sg:person.01253137160.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253137160.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea", 
            "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Im", 
        "givenName": "Hyung-Jun", 
        "id": "sg:person.01310744444.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310744444.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Ji-yong", 
        "id": "sg:person.0636264111.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636264111.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Ji Youn", 
        "id": "sg:person.0755536623.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755536623.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea", 
            "School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoo", 
        "givenName": "Byeongjun", 
        "id": "sg:person.0644264720.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644264720.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea", 
            "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Yun-Sang", 
        "id": "sg:person.01152420166.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152420166.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeong", 
        "givenName": "Jae Min", 
        "id": "sg:person.01301360400.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301360400.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea", 
            "School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hyeon", 
        "givenName": "Taeghwan", 
        "id": "sg:person.015760174517.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015760174517.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Who Kim", 
        "givenName": "Ji", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jae Sung", 
        "id": "sg:person.0677005044.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677005044.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jang", 
        "givenName": "In-Jin", 
        "id": "sg:person.01262612202.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262612202.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Joo-Youn", 
        "id": "sg:person.010475162204.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010475162204.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea", 
            "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hwang", 
        "givenName": "Do Won", 
        "id": "sg:person.0627125000.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627125000.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Chemical Engineering, Sungkyunkwan University, Suwon, Korea", 
          "id": "http://www.grid.ac/institutes/grid.264381.a", 
          "name": [
            "Laboratory for Advanced Molecular Probing (LAMP), Research Center for Convergence Nanotechnology, Korea Research Institute of Chemical Technology, Daejeon, Korea", 
            "School of Chemical Engineering, Sungkyunkwan University, Suwon, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suh", 
        "givenName": "Yung Doug", 
        "id": "sg:person.01134200335.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134200335.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea", 
            "Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Dong Soo", 
        "id": "sg:person.015617314175.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015617314175.88"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s13139-015-0342-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027850307", 
          "https://doi.org/10.1007/s13139-015-0342-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmat1251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001680978", 
          "https://doi.org/10.1038/nmat1251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1477-3155-10-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032761884", 
          "https://doi.org/10.1186/1477-3155-10-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2015.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041645996", 
          "https://doi.org/10.1038/nnano.2015.111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep10785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008235595", 
          "https://doi.org/10.1038/srep10785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12274-010-0036-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050543789", 
          "https://doi.org/10.1007/s12274-010-0036-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2007.351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022053032", 
          "https://doi.org/10.1038/nprot.2007.351"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-10-23", 
    "datePublishedReg": "2015-10-23", 
    "description": "In the field of nanomedicine, long term accumulation of nanoparticles (NPs) in the mononuclear phagocyte system (MPS) such as liver is the major hurdle in clinical translation. On the other hand, NPs could be excreted via hepatobiliary excretion pathway without overt tissue toxicity. Therefore, it is critical to develop NPs that show favorable excretion property. Herein, we demonstrated that micelle encapsulated 64Cu-labeled upconverting nanoparticles (micelle encapsulated 64Cu-NOTA-UCNPs) showed substantial hepatobiliary excretion by in vivo positron emission tomography (PET) and also upconversion luminescence imaging (ULI). Ex vivo biodistribution study reinforced the imaging results by showing clearance of 84% of initial hepatic uptake in 72\u2009hours. Hepatobiliary excretion of the UCNPs was also verified by transmission electron microscopy (TEM) examination. Micelle encapsulated 64Cu-NOTA-UCNPs could be an optimal bimodal imaging agent owing to quantifiability of 64Cu, ability of in vivo/ex vivo ULI and good hepatobiliary excretion property.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/srep15685", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "keywords": [
      "upconversion luminescence imaging", 
      "upconverting nanoparticles", 
      "field of nanomedicine", 
      "hepatobiliary excretion pathway", 
      "transmission electron microscopy examination", 
      "nanoparticles", 
      "rapid hepatobiliary excretion", 
      "vivo positron emission tomography", 
      "mononuclear phagocyte system", 
      "luminescence imaging", 
      "UCNPs", 
      "clinical translation", 
      "electron microscopy examination", 
      "major hurdle", 
      "initial hepatic uptake", 
      "microscopy examination", 
      "nanomedicine", 
      "biodistribution studies", 
      "phagocyte system", 
      "Herein", 
      "excretion pathway", 
      "properties", 
      "hepatobiliary excretion", 
      "positron emission tomography", 
      "hurdles", 
      "micelles", 
      "quantifiability", 
      "term accumulation", 
      "tissue toxicity", 
      "long-term accumulation", 
      "ex", 
      "integrated forms", 
      "imaging", 
      "emission tomography", 
      "system", 
      "field", 
      "agents", 
      "excretion (ADME) properties", 
      "ability", 
      "toxicity", 
      "hepatic uptake", 
      "uptake", 
      "excretion", 
      "results", 
      "translation", 
      "hand", 
      "liver", 
      "clearance", 
      "tomography", 
      "examination", 
      "accumulation", 
      "pathway", 
      "hours", 
      "form", 
      "study"
    ], 
    "name": "Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form", 
    "pagination": "15685", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013419289"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep15685"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26494465"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep15685", 
      "https://app.dimensions.ai/details/publication/pub.1013419289"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_654.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/srep15685"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep15685'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep15685'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep15685'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep15685'


 

This table displays all metadata directly associated to this object as RDF triples.

292 TRIPLES      21 PREDICATES      95 URIs      80 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep15685 schema:about N07212c5875a64dd88e82509cfd138a46
2 N15e04555a66f499c910df8e0d007aad8
3 N16a4bc59e48040d1b14cab54672f97f1
4 N1c5a946d85144e05873cb760d9c258e9
5 N23b324dec2aa4077b62966749e7757ca
6 N5a0bb033f8f940fd907857328173eb29
7 N6bcfa64980634f0fb3aa6d7acba93a89
8 Nb664aecc253048af91a7ca15aaf62daf
9 anzsrc-for:10
10 anzsrc-for:1007
11 schema:author N08eca472974449b6876dc1d66a61179a
12 schema:citation sg:pub.10.1007/s12274-010-0036-2
13 sg:pub.10.1007/s13139-015-0342-4
14 sg:pub.10.1038/nmat1251
15 sg:pub.10.1038/nnano.2015.111
16 sg:pub.10.1038/nprot.2007.351
17 sg:pub.10.1038/srep10785
18 sg:pub.10.1186/1477-3155-10-5
19 schema:datePublished 2015-10-23
20 schema:datePublishedReg 2015-10-23
21 schema:description In the field of nanomedicine, long term accumulation of nanoparticles (NPs) in the mononuclear phagocyte system (MPS) such as liver is the major hurdle in clinical translation. On the other hand, NPs could be excreted via hepatobiliary excretion pathway without overt tissue toxicity. Therefore, it is critical to develop NPs that show favorable excretion property. Herein, we demonstrated that micelle encapsulated 64Cu-labeled upconverting nanoparticles (micelle encapsulated 64Cu-NOTA-UCNPs) showed substantial hepatobiliary excretion by in vivo positron emission tomography (PET) and also upconversion luminescence imaging (ULI). Ex vivo biodistribution study reinforced the imaging results by showing clearance of 84% of initial hepatic uptake in 72 hours. Hepatobiliary excretion of the UCNPs was also verified by transmission electron microscopy (TEM) examination. Micelle encapsulated 64Cu-NOTA-UCNPs could be an optimal bimodal imaging agent owing to quantifiability of 64Cu, ability of in vivo/ex vivo ULI and good hepatobiliary excretion property.
22 schema:genre article
23 schema:isAccessibleForFree true
24 schema:isPartOf N2cec6e8be0c244998094b66af2a8048a
25 N70f0c9ac6eed458c95a0c8ff2ad26ba5
26 sg:journal.1045337
27 schema:keywords Herein
28 UCNPs
29 ability
30 accumulation
31 agents
32 biodistribution studies
33 clearance
34 clinical translation
35 electron microscopy examination
36 emission tomography
37 ex
38 examination
39 excretion
40 excretion (ADME) properties
41 excretion pathway
42 field
43 field of nanomedicine
44 form
45 hand
46 hepatic uptake
47 hepatobiliary excretion
48 hepatobiliary excretion pathway
49 hours
50 hurdles
51 imaging
52 initial hepatic uptake
53 integrated forms
54 liver
55 long-term accumulation
56 luminescence imaging
57 major hurdle
58 micelles
59 microscopy examination
60 mononuclear phagocyte system
61 nanomedicine
62 nanoparticles
63 pathway
64 phagocyte system
65 positron emission tomography
66 properties
67 quantifiability
68 rapid hepatobiliary excretion
69 results
70 study
71 system
72 term accumulation
73 tissue toxicity
74 tomography
75 toxicity
76 translation
77 transmission electron microscopy examination
78 upconversion luminescence imaging
79 upconverting nanoparticles
80 uptake
81 vivo positron emission tomography
82 schema:name Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form
83 schema:pagination 15685
84 schema:productId N5aeac6372d904fd5bbd770830b745423
85 N7c8a3e5379a24f3091c21422b606f8da
86 N91b9fe9369e64381a00696333a04e9ec
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013419289
88 https://doi.org/10.1038/srep15685
89 schema:sdDatePublished 2022-10-01T06:40
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N8cdfa75021c04f33939e41a64c56b580
92 schema:url https://doi.org/10.1038/srep15685
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N07212c5875a64dd88e82509cfd138a46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Animals
98 rdf:type schema:DefinedTerm
99 N08eca472974449b6876dc1d66a61179a rdf:first sg:person.0617104664.28
100 rdf:rest N6831917c479d4036acf0b8a7022026f9
101 N15e04555a66f499c910df8e0d007aad8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Mice
103 rdf:type schema:DefinedTerm
104 N16a4bc59e48040d1b14cab54672f97f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Micelles
106 rdf:type schema:DefinedTerm
107 N1c5a946d85144e05873cb760d9c258e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Biliary Tract
109 rdf:type schema:DefinedTerm
110 N23b324dec2aa4077b62966749e7757ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Positron-Emission Tomography
112 rdf:type schema:DefinedTerm
113 N2cec6e8be0c244998094b66af2a8048a schema:volumeNumber 5
114 rdf:type schema:PublicationVolume
115 N312b736289eb42bd9ed31e985378f679 rdf:first sg:person.015617314175.88
116 rdf:rest rdf:nil
117 N448d6f4a19b14817967b0516c58cbc78 rdf:first sg:person.01301360400.94
118 rdf:rest Na384ddeb1b644c329ab7ac446b3032ad
119 N47f43949865b43ed8b523145001cf1f5 rdf:first sg:person.0677005044.62
120 rdf:rest N49dd42143fbd4dceacdbae21ffe0b1b4
121 N49dd42143fbd4dceacdbae21ffe0b1b4 rdf:first sg:person.01262612202.05
122 rdf:rest Nb75fb824b5d541d7a4a84b70e71feb68
123 N5a0bb033f8f940fd907857328173eb29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Liver
125 rdf:type schema:DefinedTerm
126 N5aeac6372d904fd5bbd770830b745423 schema:name doi
127 schema:value 10.1038/srep15685
128 rdf:type schema:PropertyValue
129 N6831917c479d4036acf0b8a7022026f9 rdf:first sg:person.01253137160.09
130 rdf:rest N97be3b8fd4614506a5fce52ad1bfaf9b
131 N69b6d4e735314b85a9760e127fb1cc1a rdf:first sg:person.01152420166.90
132 rdf:rest N448d6f4a19b14817967b0516c58cbc78
133 N6bcfa64980634f0fb3aa6d7acba93a89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Humans
135 rdf:type schema:DefinedTerm
136 N6c17af9a6fb34338969a90e9c3bede08 rdf:first sg:person.0644264720.64
137 rdf:rest N69b6d4e735314b85a9760e127fb1cc1a
138 N70f0c9ac6eed458c95a0c8ff2ad26ba5 schema:issueNumber 1
139 rdf:type schema:PublicationIssue
140 N7c8a3e5379a24f3091c21422b606f8da schema:name dimensions_id
141 schema:value pub.1013419289
142 rdf:type schema:PropertyValue
143 N8cdfa75021c04f33939e41a64c56b580 schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 N91b9fe9369e64381a00696333a04e9ec schema:name pubmed_id
146 schema:value 26494465
147 rdf:type schema:PropertyValue
148 N97be3b8fd4614506a5fce52ad1bfaf9b rdf:first sg:person.01310744444.16
149 rdf:rest Nd220ac6aee0043d88d700778c70a5406
150 N9a9ebd7bbea7494dbc7480f55d369928 rdf:first sg:person.01134200335.15
151 rdf:rest N312b736289eb42bd9ed31e985378f679
152 Na384ddeb1b644c329ab7ac446b3032ad rdf:first sg:person.015760174517.62
153 rdf:rest Ne87fd41f8cae485b871960122cd873fa
154 Nb13d11d6d55948779112bceefefcbaf1 rdf:first sg:person.0755536623.32
155 rdf:rest N6c17af9a6fb34338969a90e9c3bede08
156 Nb2da495b31724354b9abb170208f09f4 schema:affiliation grid-institutes:grid.31501.36
157 schema:familyName Who Kim
158 schema:givenName Ji
159 rdf:type schema:Person
160 Nb664aecc253048af91a7ca15aaf62daf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Nanoparticles
162 rdf:type schema:DefinedTerm
163 Nb75fb824b5d541d7a4a84b70e71feb68 rdf:first sg:person.010475162204.40
164 rdf:rest Nc4ebd7b4f7ad4dd391495ecacbd981a7
165 Nc4ebd7b4f7ad4dd391495ecacbd981a7 rdf:first sg:person.0627125000.90
166 rdf:rest N9a9ebd7bbea7494dbc7480f55d369928
167 Nd220ac6aee0043d88d700778c70a5406 rdf:first sg:person.0636264111.80
168 rdf:rest Nb13d11d6d55948779112bceefefcbaf1
169 Ne87fd41f8cae485b871960122cd873fa rdf:first Nb2da495b31724354b9abb170208f09f4
170 rdf:rest N47f43949865b43ed8b523145001cf1f5
171 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
172 schema:name Technology
173 rdf:type schema:DefinedTerm
174 anzsrc-for:1007 schema:inDefinedTermSet anzsrc-for:
175 schema:name Nanotechnology
176 rdf:type schema:DefinedTerm
177 sg:journal.1045337 schema:issn 2045-2322
178 schema:name Scientific Reports
179 schema:publisher Springer Nature
180 rdf:type schema:Periodical
181 sg:person.010475162204.40 schema:affiliation grid-institutes:grid.31501.36
182 schema:familyName Cho
183 schema:givenName Joo-Youn
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010475162204.40
185 rdf:type schema:Person
186 sg:person.01134200335.15 schema:affiliation grid-institutes:grid.264381.a
187 schema:familyName Suh
188 schema:givenName Yung Doug
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134200335.15
190 rdf:type schema:Person
191 sg:person.01152420166.90 schema:affiliation grid-institutes:grid.31501.36
192 schema:familyName Lee
193 schema:givenName Yun-Sang
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152420166.90
195 rdf:type schema:Person
196 sg:person.01253137160.09 schema:affiliation grid-institutes:grid.29869.3c
197 schema:familyName Nam
198 schema:givenName Sang Hwan
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253137160.09
200 rdf:type schema:Person
201 sg:person.01262612202.05 schema:affiliation grid-institutes:grid.31501.36
202 schema:familyName Jang
203 schema:givenName In-Jin
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262612202.05
205 rdf:type schema:Person
206 sg:person.01301360400.94 schema:affiliation grid-institutes:grid.31501.36
207 schema:familyName Jeong
208 schema:givenName Jae Min
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301360400.94
210 rdf:type schema:Person
211 sg:person.01310744444.16 schema:affiliation grid-institutes:grid.31501.36
212 schema:familyName Im
213 schema:givenName Hyung-Jun
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310744444.16
215 rdf:type schema:Person
216 sg:person.015617314175.88 schema:affiliation grid-institutes:grid.31501.36
217 schema:familyName Lee
218 schema:givenName Dong Soo
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015617314175.88
220 rdf:type schema:Person
221 sg:person.015760174517.62 schema:affiliation grid-institutes:grid.31501.36
222 schema:familyName Hyeon
223 schema:givenName Taeghwan
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015760174517.62
225 rdf:type schema:Person
226 sg:person.0617104664.28 schema:affiliation grid-institutes:grid.31501.36
227 schema:familyName Seo
228 schema:givenName Hyo Jung
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617104664.28
230 rdf:type schema:Person
231 sg:person.0627125000.90 schema:affiliation grid-institutes:grid.31501.36
232 schema:familyName Hwang
233 schema:givenName Do Won
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627125000.90
235 rdf:type schema:Person
236 sg:person.0636264111.80 schema:affiliation grid-institutes:grid.31501.36
237 schema:familyName Park
238 schema:givenName Ji-yong
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636264111.80
240 rdf:type schema:Person
241 sg:person.0644264720.64 schema:affiliation grid-institutes:grid.31501.36
242 schema:familyName Yoo
243 schema:givenName Byeongjun
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644264720.64
245 rdf:type schema:Person
246 sg:person.0677005044.62 schema:affiliation grid-institutes:grid.31501.36
247 schema:familyName Lee
248 schema:givenName Jae Sung
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677005044.62
250 rdf:type schema:Person
251 sg:person.0755536623.32 schema:affiliation grid-institutes:grid.31501.36
252 schema:familyName Lee
253 schema:givenName Ji Youn
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755536623.32
255 rdf:type schema:Person
256 sg:pub.10.1007/s12274-010-0036-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050543789
257 https://doi.org/10.1007/s12274-010-0036-2
258 rdf:type schema:CreativeWork
259 sg:pub.10.1007/s13139-015-0342-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027850307
260 https://doi.org/10.1007/s13139-015-0342-4
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nmat1251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001680978
263 https://doi.org/10.1038/nmat1251
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nnano.2015.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041645996
266 https://doi.org/10.1038/nnano.2015.111
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/nprot.2007.351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022053032
269 https://doi.org/10.1038/nprot.2007.351
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/srep10785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008235595
272 https://doi.org/10.1038/srep10785
273 rdf:type schema:CreativeWork
274 sg:pub.10.1186/1477-3155-10-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032761884
275 https://doi.org/10.1186/1477-3155-10-5
276 rdf:type schema:CreativeWork
277 grid-institutes:grid.264381.a schema:alternateName School of Chemical Engineering, Sungkyunkwan University, Suwon, Korea
278 schema:name Laboratory for Advanced Molecular Probing (LAMP), Research Center for Convergence Nanotechnology, Korea Research Institute of Chemical Technology, Daejeon, Korea
279 School of Chemical Engineering, Sungkyunkwan University, Suwon, Korea
280 rdf:type schema:Organization
281 grid-institutes:grid.29869.3c schema:alternateName Laboratory for Advanced Molecular Probing (LAMP), Research Center for Convergence Nanotechnology, Korea Research Institute of Chemical Technology, Daejeon, Korea
282 schema:name Laboratory for Advanced Molecular Probing (LAMP), Research Center for Convergence Nanotechnology, Korea Research Institute of Chemical Technology, Daejeon, Korea
283 rdf:type schema:Organization
284 grid-institutes:grid.31501.36 schema:alternateName Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea
285 Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea
286 School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea
287 schema:name Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea
288 Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea
289 Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea
290 Department of Nuclear medicine, Seoul National University College of Medicine, Seoul, Korea
291 School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea
292 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...