Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10-23

AUTHORS

Hyo Jung Seo, Sang Hwan Nam, Hyung-Jun Im, Ji-yong Park, Ji Youn Lee, Byeongjun Yoo, Yun-Sang Lee, Jae Min Jeong, Taeghwan Hyeon, Ji Who Kim, Jae Sung Lee, In-Jin Jang, Joo-Youn Cho, Do Won Hwang, Yung Doug Suh, Dong Soo Lee

ABSTRACT

In the field of nanomedicine, long term accumulation of nanoparticles (NPs) in the mononuclear phagocyte system (MPS) such as liver is the major hurdle in clinical translation. On the other hand, NPs could be excreted via hepatobiliary excretion pathway without overt tissue toxicity. Therefore, it is critical to develop NPs that show favorable excretion property. Herein, we demonstrated that micelle encapsulated 64Cu-labeled upconverting nanoparticles (micelle encapsulated 64Cu-NOTA-UCNPs) showed substantial hepatobiliary excretion by in vivo positron emission tomography (PET) and also upconversion luminescence imaging (ULI). Ex vivo biodistribution study reinforced the imaging results by showing clearance of 84% of initial hepatic uptake in 72 hours. Hepatobiliary excretion of the UCNPs was also verified by transmission electron microscopy (TEM) examination. Micelle encapsulated 64Cu-NOTA-UCNPs could be an optimal bimodal imaging agent owing to quantifiability of 64Cu, ability of in vivo/ex vivo ULI and good hepatobiliary excretion property. More... »

PAGES

15685

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep15685

DOI

http://dx.doi.org/10.1038/srep15685

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013419289

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26494465


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