Epigenetic silencing of the MUPCDH gene as a possible prognostic biomarker for cyst growth in ADPKD View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Yu Mi Woo, Yubin Shin, Jung-Ah Hwang, Young-Hwan Hwang, Sunyoung Lee, Eun Young Park, Hyun Kyung Kong, Hayne Cho Park, Yeon-Su Lee, Jong Hoon Park

ABSTRACT

Although autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease, and is characterized by the formation of multiple fluid-filled cysts, which results in renal failure, early diagnosis and treatment of ADPKD have yet to be defined. Herein, we observed that the promoter region of the gene encoding mucin-like protocadherin (MUPCDH) was hypermethylated in the renal tissue of patients with ADPKD compared to non-ADPKD controls. Inversely, MUPCDH was significantly repressed in ADPKD, especially in cyst-lining cells. Our results indicate that aberrant methylation of MUPCDH promoter CpG islands may be negatively correlated with reduced expression level of MUPCDH and that this contributes to abnormal cell proliferation in ADPKD. It suggests that methylation status of MUPCDH promoter can be used as a novel epigenetic biomarker and a therapeutic target in ADPKD. More... »

PAGES

15238

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep15238

DOI

http://dx.doi.org/10.1038/srep15238

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047072386

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26463459


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep15238'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep15238'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep15238'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep15238'


 

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