Kaempferol Identified by Zebrafish Assay and Fine Fractionations Strategy from Dysosma versipellis Inhibits Angiogenesis through VEGF and FGF Pathways View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-11

AUTHORS

Fang Liang, Yuxiang Han, Hao Gao, Shengchang Xin, Shaodan Chen, Nan Wang, Wei Qin, Hanbing Zhong, Shuo Lin, Xinsheng Yao, Song Li

ABSTRACT

Natural products are a rich resource for the discovery of therapeutic substances. By directly using 504 fine fractions from isolated traditional Chinese medicine plants, we performed a transgenic zebrafish based screen for anti-angiogenesis substances. One fraction, DYVE-D3, was found to inhibit the growth of intersegmental vessels in the zebrafish vasculature. Bioassay-guided isolation of DYVE-D3 indicates that the flavonoid kaempferol was the active substance. Kaempferol also inhibited the proliferation and migration of HUVECs in vitro. Furthermore, we found that kaempferol suppressed angiogenesis through inhibiting VEGFR2 expression, which can be enhanced by FGF inhibition. In summary, this study shows that the construction of fine fraction libraries allows efficient identification of active substances from natural products. More... »

PAGES

14468

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep14468

DOI

http://dx.doi.org/10.1038/srep14468

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041031523

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26446489


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