Ontology type: schema:ScholarlyArticle Open Access: True
2015-11
AUTHORSZongbin Liu, Yeonju Lee, Joon hee Jang, Ying Li, Xin Han, Kenji Yokoi, Mauro Ferrari, Ledu Zhou, Lidong Qin
ABSTRACTThe extensive phenotypic and functional heterogeneity of cancer cells plays an important role in tumor progression and therapeutic resistance. Characterizing this heterogeneity and identifying invasive phenotype may provide possibility to improve chemotherapy treatment. By mimicking cancer cell perfusion through circulatory system in metastasis, we develop a unique microfluidic cytometry (MC) platform to separate cancer cells at high throughput, and further derive a physical parameter 'transportability' to characterize the ability to pass through micro-constrictions. The transportability is determined by cell stiffness and cell-surface frictional property, and can be used to probe tumor heterogeneity, discriminate more invasive phenotypes and correlate with biomarker expressions in breast cancer cells. Decreased cell stiffness and cell-surface frictional force leads to an increase in transportability and may be a feature of invasive cancer cells by promoting cell perfusion through narrow spaces in circulatory system. The MC-Chip provides a promising microfluidic platform for studying cell mechanics and transportability could be used as a novel marker for probing tumor heterogeneity and determining invasive phenotypes. More... »
PAGES14272
http://scigraph.springernature.com/pub.10.1038/srep14272
DOIhttp://dx.doi.org/10.1038/srep14272
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26404901
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep14272'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep14272'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep14272'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep14272'
This table displays all metadata directly associated to this object as RDF triples.
360 TRIPLES
21 PREDICATES
94 URIs
36 LITERALS
24 BLANK NODES