Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma View Full Text


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Article Info

DATE

2015-10-27

AUTHORS

Chenguang Li, Zhibo Gao, Fei Li, Xiangchun Li, Yihua Sun, Mengyun Wang, Dan Li, Rui Wang, Fuming Li, Rong Fang, Yunjian Pan, Xiaoyang Luo, Jing He, Liangtao Zheng, Jufeng Xia, Lixin Qiu, Jun He, Ting Ye, Ruoxin Zhang, Minghui He, Meiling Zhu, Haichuan Hu, Tingyan Shi, Xiaoyan Zhou, Menghong Sun, Shilin Tian, Yong Zhou, Qiaoxiu Wang, Longyun Chen, Guangliang Yin, Jingya Lu, Renhua Wu, Guangwu Guo, Yingrui Li, Xueda Hu, Lin Li, A Asan, Qin Wang, Ye Yin, Qiang Feng, Bin Wang, Hang Wang, Mingbang Wang, Xiaonan Yang, Xiuqing Zhang, Huanming Yang, Li Jin, Cun-Yu Wang, Hongbin Ji, Haiquan Chen, Jun Wang, Qingyi Wei

ABSTRACT

Lung squamous cell carcinoma (SQCC) accounts for about 30% of all lung cancer cases. Understanding of mutational landscape for this subtype of lung cancer in Chinese patients is currently limited. We performed whole exome sequencing in samples from 100 patients with lung SQCCs to search for somatic mutations and the subsequent target capture sequencing in another 98 samples for validation. We identified 20 significantly mutated genes, including TP53, CDH10, NFE2L2 and PTEN. Pathways with frequently mutated genes included those of cell-cell adhesion/Wnt/Hippo in 76%, oxidative stress response in 21%, and phosphatidylinositol-3-OH kinase in 36% of the tested tumor samples. Mutations of Chromatin regulatory factor genes were identified at a lower frequency. In functional assays, we observed that knockdown of CDH10 promoted cell proliferation, soft-agar colony formation, cell migration and cell invasion, and overexpression of CDH10 inhibited cell proliferation. This mutational landscape of lung SQCC in Chinese patients improves our current understanding of lung carcinogenesis, early diagnosis and personalized therapy. More... »

PAGES

14237

References to SciGraph publications

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  • Journal

    TITLE

    Scientific Reports

    ISSUE

    1

    VOLUME

    5

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep14237

    DOI

    http://dx.doi.org/10.1038/srep14237

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042033212

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26503331


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