Imbalance between the expression dosages of X-chromosome and autosomal genes in mammalian oocytes View Full Text


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Article Info

DATE

2015-11

AUTHORS

Atsushi Fukuda, Motohiko Tanino, Ryo Matoba, Akihiro Umezawa, Hidenori Akutsu

ABSTRACT

Oocytes have unique characteristics compared with other cell types. In mouse and human oocytes, two X chromosomes are maintained in the active state. Previous microarray studies have shown that the balance of the expression state is maintained in haploid oocytes. Here, we investigated transcripts using RNA-sequence technology in mouse and human oocytes. The median expression ratio between X chromosome and autosomal genes (X:A) in immature mouse oocytes increased as the gene expression levels increased, reaching a value of 1. However, the ratio in mature oocytes was under 1 for all expression categories. Moreover, we observed a markedly low ratio resulting from the bimodal expression patterns of X-linked genes. The low X:A expression ratio in mature oocyte was independent of DNA methylation. While mature human oocytes exhibited a slightly low X:A expression ratio, this was the result of the skewed high frequency of lowly expressed X-linked genes rather than the bimodal state. We propose that this imbalance between the expression dosages of X-chromosome and autosomal genes is a feature of transcripts in mammalian oocytes lacking X-chromosome inactivation. More... »

PAGES

14101

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep14101

    DOI

    http://dx.doi.org/10.1038/srep14101

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035180212

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26370379


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