Diversity and evolution of cytochrome P450 monooxygenases in Oomycetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-09

AUTHORS

Mopeli Marshal Sello, Norventia Jafta, David R Nelson, Wanping Chen, Jae-Hyuk Yu, Mohammad Parvez, Ipeleng Kopano Rosinah Kgosiemang, Richie Monyaki, Seiso Caiphus Raselemane, Lehlohonolo Benedict Qhanya, Ntsane Trevor Mthakathi, Samson Sitheni Mashele, Khajamohiddin Syed

ABSTRACT

Cytochrome P450 monooxygenases (P450s) are heme-thiolate proteins whose role as drug targets against pathogens, as well as in valuable chemical production and bioremediation, has been explored. In this study we performed comprehensive comparative analysis of P450s in 13 newly explored oomycete pathogens. Three hundred and fifty-six P450s were found in oomycetes. These P450s were grouped into 15 P450 families and 84 P450 subfamilies. Among these, nine P450 families and 31 P450 subfamilies were newly found in oomycetes. Research revealed that oomycetes belonging to different orders contain distinct P450 families and subfamilies in their genomes. Evolutionary analysis and sequence homology data revealed P450 family blooms in oomycetes. Tandem arrangement of a large number of P450s belonging to the same family indicated that P450 family blooming is possibly due to its members' duplications. A unique combination of amino acid patterns was observed at EXXR and CXG motifs for the P450 families CYP5014, CYP5015 and CYP5017. A novel P450 fusion protein (CYP5619 family) with an N-terminal P450 domain fused to a heme peroxidase/dioxygenase domain was discovered in Saprolegnia declina. Oomycete P450 patterns suggested host influence in shaping their P450 content. This manuscript serves as reference for future P450 annotations in newly explored oomycetes. More... »

PAGES

11572

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep11572

DOI

http://dx.doi.org/10.1038/srep11572

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020505934

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26129850


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Motifs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytochrome P-450 Enzyme System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evolution, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Annotation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multigene Family", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oomycetes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phylogeny", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plants", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Central University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.428369.2", 
          "name": [
            "Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sello", 
        "givenName": "Mopeli Marshal", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.428369.2", 
          "name": [
            "Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jafta", 
        "givenName": "Norventia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tennessee Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nelson", 
        "givenName": "David R", 
        "id": "sg:person.0642103474.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642103474.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Huazhong Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.35155.37", 
          "name": [
            "College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei Province, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Wanping", 
        "id": "sg:person.0742525010.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742525010.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "Department of Bacteriology, University of Wisconsin-Madison, 3155 MSB, 1550 Linden Drive, Madison WI 53706, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Jae-Hyuk", 
        "id": "sg:person.0621715152.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621715152.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.428369.2", 
          "name": [
            "Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parvez", 
        "givenName": "Mohammad", 
        "id": "sg:person.01055364301.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055364301.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.428369.2", 
          "name": [
            "Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kgosiemang", 
        "givenName": "Ipeleng Kopano Rosinah", 
        "id": "sg:person.01123477501.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123477501.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.428369.2", 
          "name": [
            "Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Monyaki", 
        "givenName": "Richie", 
        "id": "sg:person.01171612701.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171612701.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.428369.2", 
          "name": [
            "Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raselemane", 
        "givenName": "Seiso Caiphus", 
        "id": "sg:person.01237726101.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237726101.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.428369.2", 
          "name": [
            "Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qhanya", 
        "givenName": "Lehlohonolo Benedict", 
        "id": "sg:person.01306041301.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306041301.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.428369.2", 
          "name": [
            "Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mthakathi", 
        "givenName": "Ntsane Trevor", 
        "id": "sg:person.01354154501.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354154501.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.428369.2", 
          "name": [
            "Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sitheni Mashele", 
        "givenName": "Samson", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.428369.2", 
          "name": [
            "Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Syed", 
        "givenName": "Khajamohiddin", 
        "id": "sg:person.0716036136.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716036136.69"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.bbrc.2010.07.094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000460021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pcbi.1002195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001034143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/protein/gzt036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002098104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2011.02.121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003412510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2010-11-7-r73", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005615366", 
          "https://doi.org/10.1186/gb-2010-11-7-r73"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1364-3703.2011.00754.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007488384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btm404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007683223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt1223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010707975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr9500500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011302001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr9500500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011302001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0086683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011461425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkq1189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013912470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0095616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014270316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.2012.0476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014680783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.849004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016890117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3852/13-002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017279706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tim.2007.10.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018845426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btl529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019858005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/gbe/evu132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020610574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.2012.0428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020638296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.03767-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021170559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.2012.0430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021983247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.01195-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022777460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00203-011-0753-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022848793", 
          "https://doi.org/10.1007/s00203-011-0753-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-8137.2009.02895.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024435774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbapap.2010.08.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025769303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025806080", 
          "https://doi.org/10.1038/nature08358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025806080", 
          "https://doi.org/10.1038/nature08358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/msp077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028540883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/msp077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028540883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0742-8413(98)10027-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029746602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1003272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030475239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-13-525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031009486", 
          "https://doi.org/10.1186/1471-2164-13-525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6807-10-34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031328011", 
          "https://doi.org/10.1186/1472-6807-10-34"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13258-013-0170-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031553107", 
          "https://doi.org/10.1007/s13258-013-0170-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2148-7-30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034459120", 
          "https://doi.org/10.1186/1471-2148-7-30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-7364-4-1-59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036064711", 
          "https://doi.org/10.1186/1479-7364-4-1-59"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.2012.0434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036288423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0107209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036753549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0075072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037478300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jbiotec.2006.01.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039915282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/18.20.6097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041886714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.r113.462275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042225024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbapap.2010.06.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042790849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/ec.2.2.191-199.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042881206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1105/tpc.107.056663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043179727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m005617200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043400331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1128796", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043715710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m809152200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044595461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt1183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047265540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00709-011-0269-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049135393", 
          "https://doi.org/10.1007/s00709-011-0269-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/msr121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049273973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4612-3730-3_11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053113941", 
          "https://doi.org/10.1007/978-1-4612-3730-3_11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1195203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062462742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077374000", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.molbev.a040771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083487917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9780470475898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1109368298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1109368298", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-09", 
    "datePublishedReg": "2015-09-01", 
    "description": "Cytochrome P450 monooxygenases (P450s) are heme-thiolate proteins whose role as drug targets against pathogens, as well as in valuable chemical production and bioremediation, has been explored. In this study we performed comprehensive comparative analysis of P450s in 13 newly explored oomycete pathogens. Three hundred and fifty-six P450s were found in oomycetes. These P450s were grouped into 15 P450 families and 84 P450 subfamilies. Among these, nine P450 families and 31 P450 subfamilies were newly found in oomycetes. Research revealed that oomycetes belonging to different orders contain distinct P450 families and subfamilies in their genomes. Evolutionary analysis and sequence homology data revealed P450 family blooms in oomycetes. Tandem arrangement of a large number of P450s belonging to the same family indicated that P450 family blooming is possibly due to its members' duplications. A unique combination of amino acid patterns was observed at EXXR and CXG motifs for the P450 families CYP5014, CYP5015 and CYP5017. A novel P450 fusion protein (CYP5619 family) with an N-terminal P450 domain fused to a heme peroxidase/dioxygenase domain was discovered in Saprolegnia declina. Oomycete P450 patterns suggested host influence in shaping their P450 content. This manuscript serves as reference for future P450 annotations in newly explored oomycetes. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep11572", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "Diversity and evolution of cytochrome P450 monooxygenases in Oomycetes", 
    "pagination": "11572", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "61b518261d1b99002bdc344a6e9fa9f635f2b3de05aabebce2949941fb36b32e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26129850"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep11572"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020505934"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep11572", 
      "https://app.dimensions.ai/details/publication/pub.1020505934"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53981_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2015/150701/srep11572/full/srep11572.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep11572'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep11572'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep11572'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep11572'


 

This table displays all metadata directly associated to this object as RDF triples.

379 TRIPLES      21 PREDICATES      96 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep11572 schema:about N0422dde9de25427f8441b07a14ca4bf2
2 N13bf7770cf91476199cda1c4566a874f
3 N17e557109b7945e18544c247ea41ede2
4 N2cb12600a5534494baaa210c91bccf4b
5 N3697d69ac5104f0fa5d6f7d206aeb52c
6 N3a8f0058205142f18b8b748a97294678
7 N59d6050ab0a84f1598079fd52d441f77
8 N72b2c59f12c142628de45b269bf9926d
9 N933feb6795e24a1f9727e46b1c605ed6
10 Nb32e108a7cf5455a9fe8ea80e71284cc
11 Nbb2bff6c87e3463192ffe0d7b5068aba
12 Nfc593a25168045c595c52fa74dd20bef
13 anzsrc-for:06
14 anzsrc-for:0601
15 schema:author Nd9ca568fcd6f439390e16c10256fb31f
16 schema:citation sg:pub.10.1007/978-1-4612-3730-3_11
17 sg:pub.10.1007/s00203-011-0753-2
18 sg:pub.10.1007/s00709-011-0269-2
19 sg:pub.10.1007/s13258-013-0170-9
20 sg:pub.10.1038/nature08358
21 sg:pub.10.1186/1471-2148-7-30
22 sg:pub.10.1186/1471-2164-13-525
23 sg:pub.10.1186/1472-6807-10-34
24 sg:pub.10.1186/1479-7364-4-1-59
25 sg:pub.10.1186/gb-2010-11-7-r73
26 https://app.dimensions.ai/details/publication/pub.1077374000
27 https://app.dimensions.ai/details/publication/pub.1109368298
28 https://doi.org/10.1002/9780470475898
29 https://doi.org/10.1016/j.bbapap.2010.06.012
30 https://doi.org/10.1016/j.bbapap.2010.08.008
31 https://doi.org/10.1016/j.bbrc.2010.07.094
32 https://doi.org/10.1016/j.bbrc.2011.02.121
33 https://doi.org/10.1016/j.jbiotec.2006.01.026
34 https://doi.org/10.1016/j.tim.2007.10.013
35 https://doi.org/10.1016/s0742-8413(98)10027-0
36 https://doi.org/10.1021/cr9500500
37 https://doi.org/10.1074/jbc.m005617200
38 https://doi.org/10.1074/jbc.m809152200
39 https://doi.org/10.1074/jbc.r113.462275
40 https://doi.org/10.1093/bioinformatics/btl529
41 https://doi.org/10.1093/bioinformatics/btm404
42 https://doi.org/10.1093/gbe/evu132
43 https://doi.org/10.1093/molbev/msp077
44 https://doi.org/10.1093/molbev/msr121
45 https://doi.org/10.1093/nar/18.20.6097
46 https://doi.org/10.1093/nar/gkq1189
47 https://doi.org/10.1093/nar/gkt1183
48 https://doi.org/10.1093/nar/gkt1223
49 https://doi.org/10.1093/oxfordjournals.molbev.a040771
50 https://doi.org/10.1093/protein/gzt036
51 https://doi.org/10.1098/rstb.2012.0428
52 https://doi.org/10.1098/rstb.2012.0430
53 https://doi.org/10.1098/rstb.2012.0434
54 https://doi.org/10.1098/rstb.2012.0476
55 https://doi.org/10.1101/gr.849004
56 https://doi.org/10.1105/tpc.107.056663
57 https://doi.org/10.1111/j.1364-3703.2011.00754.x
58 https://doi.org/10.1111/j.1469-8137.2009.02895.x
59 https://doi.org/10.1126/science.1128796
60 https://doi.org/10.1126/science.1195203
61 https://doi.org/10.1128/aem.01195-14
62 https://doi.org/10.1128/aem.03767-12
63 https://doi.org/10.1128/ec.2.2.191-199.2003
64 https://doi.org/10.1371/journal.pcbi.1002195
65 https://doi.org/10.1371/journal.pgen.1003272
66 https://doi.org/10.1371/journal.pone.0075072
67 https://doi.org/10.1371/journal.pone.0086683
68 https://doi.org/10.1371/journal.pone.0095616
69 https://doi.org/10.1371/journal.pone.0107209
70 https://doi.org/10.3852/13-002
71 schema:datePublished 2015-09
72 schema:datePublishedReg 2015-09-01
73 schema:description Cytochrome P450 monooxygenases (P450s) are heme-thiolate proteins whose role as drug targets against pathogens, as well as in valuable chemical production and bioremediation, has been explored. In this study we performed comprehensive comparative analysis of P450s in 13 newly explored oomycete pathogens. Three hundred and fifty-six P450s were found in oomycetes. These P450s were grouped into 15 P450 families and 84 P450 subfamilies. Among these, nine P450 families and 31 P450 subfamilies were newly found in oomycetes. Research revealed that oomycetes belonging to different orders contain distinct P450 families and subfamilies in their genomes. Evolutionary analysis and sequence homology data revealed P450 family blooms in oomycetes. Tandem arrangement of a large number of P450s belonging to the same family indicated that P450 family blooming is possibly due to its members' duplications. A unique combination of amino acid patterns was observed at EXXR and CXG motifs for the P450 families CYP5014, CYP5015 and CYP5017. A novel P450 fusion protein (CYP5619 family) with an N-terminal P450 domain fused to a heme peroxidase/dioxygenase domain was discovered in Saprolegnia declina. Oomycete P450 patterns suggested host influence in shaping their P450 content. This manuscript serves as reference for future P450 annotations in newly explored oomycetes.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree true
77 schema:isPartOf N6be2d2d2f3774938915312db938b5676
78 Nfc9443b0b6c7483f9d5d9fe0fae65678
79 sg:journal.1045337
80 schema:name Diversity and evolution of cytochrome P450 monooxygenases in Oomycetes
81 schema:pagination 11572
82 schema:productId N36aa322382d04ef1aee96614d283fa78
83 N5b88504440d94f0ea009583d3c0d5a63
84 N9b9ea53a83df44d6a3a52ee712dfdeb5
85 Ndc77adf1fa3e49f485db777e0e7df888
86 Ned3cf06bf21d461ebaeaa6f1e329a7c1
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020505934
88 https://doi.org/10.1038/srep11572
89 schema:sdDatePublished 2019-04-11T12:11
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N1e937368e95949c9a6094c37f8d95be8
92 schema:url http://www.nature.com/srep/2015/150701/srep11572/full/srep11572.html
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N0422dde9de25427f8441b07a14ca4bf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Multigene Family
98 rdf:type schema:DefinedTerm
99 N13bf7770cf91476199cda1c4566a874f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Molecular Sequence Annotation
101 rdf:type schema:DefinedTerm
102 N17e557109b7945e18544c247ea41ede2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Cytochrome P-450 Enzyme System
104 rdf:type schema:DefinedTerm
105 N1e937368e95949c9a6094c37f8d95be8 schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 N29d311b072f948c8b03e6e50f55ee49d schema:affiliation https://www.grid.ac/institutes/grid.428369.2
108 schema:familyName Sello
109 schema:givenName Mopeli Marshal
110 rdf:type schema:Person
111 N2cb12600a5534494baaa210c91bccf4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Oomycetes
113 rdf:type schema:DefinedTerm
114 N2d737cf93f974f58a1bea10abae1223b rdf:first sg:person.01171612701.41
115 rdf:rest N813697f985084b82b491007f3a5a2637
116 N36877b575d0e420096220d142ea630cd schema:affiliation https://www.grid.ac/institutes/grid.428369.2
117 schema:familyName Jafta
118 schema:givenName Norventia
119 rdf:type schema:Person
120 N3697d69ac5104f0fa5d6f7d206aeb52c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Plants
122 rdf:type schema:DefinedTerm
123 N36aa322382d04ef1aee96614d283fa78 schema:name readcube_id
124 schema:value 61b518261d1b99002bdc344a6e9fa9f635f2b3de05aabebce2949941fb36b32e
125 rdf:type schema:PropertyValue
126 N3a8f0058205142f18b8b748a97294678 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Animals
128 rdf:type schema:DefinedTerm
129 N4abf4b78ca074f369d8d7b92fbd9ce77 rdf:first sg:person.01055364301.08
130 rdf:rest Nd9719d02ba1945cabad0afa2f2d68f1d
131 N59d6050ab0a84f1598079fd52d441f77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Genetic Variation
133 rdf:type schema:DefinedTerm
134 N5b88504440d94f0ea009583d3c0d5a63 schema:name doi
135 schema:value 10.1038/srep11572
136 rdf:type schema:PropertyValue
137 N5c65eb85084048e0b70c055eca630ccd rdf:first sg:person.0716036136.69
138 rdf:rest rdf:nil
139 N611115802b724c819738b06a2d240e4c rdf:first N70b5ee2c66434ab4b96cba30b2723a4b
140 rdf:rest N5c65eb85084048e0b70c055eca630ccd
141 N6be2d2d2f3774938915312db938b5676 schema:volumeNumber 5
142 rdf:type schema:PublicationVolume
143 N70b5ee2c66434ab4b96cba30b2723a4b schema:affiliation https://www.grid.ac/institutes/grid.428369.2
144 schema:familyName Sitheni Mashele
145 schema:givenName Samson
146 rdf:type schema:Person
147 N72b2c59f12c142628de45b269bf9926d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Amino Acid Motifs
149 rdf:type schema:DefinedTerm
150 N7eee57a0ec6c4f2a8e5a2c5dfa653cdb rdf:first sg:person.0642103474.70
151 rdf:rest Ne7b5c2fecbbd47dcbeaa86d81e4f066f
152 N813697f985084b82b491007f3a5a2637 rdf:first sg:person.01237726101.82
153 rdf:rest N97127aa6769746f0aff178ef8ecb289b
154 N92b7ee4676074d49a3acbfe3fd5899a2 rdf:first sg:person.01354154501.17
155 rdf:rest N611115802b724c819738b06a2d240e4c
156 N933feb6795e24a1f9727e46b1c605ed6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Phylogeny
158 rdf:type schema:DefinedTerm
159 N97127aa6769746f0aff178ef8ecb289b rdf:first sg:person.01306041301.29
160 rdf:rest N92b7ee4676074d49a3acbfe3fd5899a2
161 N9b9ea53a83df44d6a3a52ee712dfdeb5 schema:name pubmed_id
162 schema:value 26129850
163 rdf:type schema:PropertyValue
164 Na61daf04db7f402aa354e3927a5464a9 rdf:first N36877b575d0e420096220d142ea630cd
165 rdf:rest N7eee57a0ec6c4f2a8e5a2c5dfa653cdb
166 Nb32e108a7cf5455a9fe8ea80e71284cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Amino Acid Sequence
168 rdf:type schema:DefinedTerm
169 Nbb2bff6c87e3463192ffe0d7b5068aba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Molecular Sequence Data
171 rdf:type schema:DefinedTerm
172 Ncf2c064fb1a04e5f87a530f33fc22b17 rdf:first sg:person.0621715152.69
173 rdf:rest N4abf4b78ca074f369d8d7b92fbd9ce77
174 Nd9719d02ba1945cabad0afa2f2d68f1d rdf:first sg:person.01123477501.14
175 rdf:rest N2d737cf93f974f58a1bea10abae1223b
176 Nd9ca568fcd6f439390e16c10256fb31f rdf:first N29d311b072f948c8b03e6e50f55ee49d
177 rdf:rest Na61daf04db7f402aa354e3927a5464a9
178 Ndc77adf1fa3e49f485db777e0e7df888 schema:name dimensions_id
179 schema:value pub.1020505934
180 rdf:type schema:PropertyValue
181 Ne7b5c2fecbbd47dcbeaa86d81e4f066f rdf:first sg:person.0742525010.90
182 rdf:rest Ncf2c064fb1a04e5f87a530f33fc22b17
183 Ned3cf06bf21d461ebaeaa6f1e329a7c1 schema:name nlm_unique_id
184 schema:value 101563288
185 rdf:type schema:PropertyValue
186 Nfc593a25168045c595c52fa74dd20bef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Evolution, Molecular
188 rdf:type schema:DefinedTerm
189 Nfc9443b0b6c7483f9d5d9fe0fae65678 schema:issueNumber 1
190 rdf:type schema:PublicationIssue
191 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
192 schema:name Biological Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
195 schema:name Biochemistry and Cell Biology
196 rdf:type schema:DefinedTerm
197 sg:journal.1045337 schema:issn 2045-2322
198 schema:name Scientific Reports
199 rdf:type schema:Periodical
200 sg:person.01055364301.08 schema:affiliation https://www.grid.ac/institutes/grid.428369.2
201 schema:familyName Parvez
202 schema:givenName Mohammad
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055364301.08
204 rdf:type schema:Person
205 sg:person.01123477501.14 schema:affiliation https://www.grid.ac/institutes/grid.428369.2
206 schema:familyName Kgosiemang
207 schema:givenName Ipeleng Kopano Rosinah
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123477501.14
209 rdf:type schema:Person
210 sg:person.01171612701.41 schema:affiliation https://www.grid.ac/institutes/grid.428369.2
211 schema:familyName Monyaki
212 schema:givenName Richie
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171612701.41
214 rdf:type schema:Person
215 sg:person.01237726101.82 schema:affiliation https://www.grid.ac/institutes/grid.428369.2
216 schema:familyName Raselemane
217 schema:givenName Seiso Caiphus
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237726101.82
219 rdf:type schema:Person
220 sg:person.01306041301.29 schema:affiliation https://www.grid.ac/institutes/grid.428369.2
221 schema:familyName Qhanya
222 schema:givenName Lehlohonolo Benedict
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306041301.29
224 rdf:type schema:Person
225 sg:person.01354154501.17 schema:affiliation https://www.grid.ac/institutes/grid.428369.2
226 schema:familyName Mthakathi
227 schema:givenName Ntsane Trevor
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354154501.17
229 rdf:type schema:Person
230 sg:person.0621715152.69 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
231 schema:familyName Yu
232 schema:givenName Jae-Hyuk
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621715152.69
234 rdf:type schema:Person
235 sg:person.0642103474.70 schema:affiliation https://www.grid.ac/institutes/grid.267301.1
236 schema:familyName Nelson
237 schema:givenName David R
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642103474.70
239 rdf:type schema:Person
240 sg:person.0716036136.69 schema:affiliation https://www.grid.ac/institutes/grid.428369.2
241 schema:familyName Syed
242 schema:givenName Khajamohiddin
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716036136.69
244 rdf:type schema:Person
245 sg:person.0742525010.90 schema:affiliation https://www.grid.ac/institutes/grid.35155.37
246 schema:familyName Chen
247 schema:givenName Wanping
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742525010.90
249 rdf:type schema:Person
250 sg:pub.10.1007/978-1-4612-3730-3_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053113941
251 https://doi.org/10.1007/978-1-4612-3730-3_11
252 rdf:type schema:CreativeWork
253 sg:pub.10.1007/s00203-011-0753-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022848793
254 https://doi.org/10.1007/s00203-011-0753-2
255 rdf:type schema:CreativeWork
256 sg:pub.10.1007/s00709-011-0269-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049135393
257 https://doi.org/10.1007/s00709-011-0269-2
258 rdf:type schema:CreativeWork
259 sg:pub.10.1007/s13258-013-0170-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031553107
260 https://doi.org/10.1007/s13258-013-0170-9
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nature08358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025806080
263 https://doi.org/10.1038/nature08358
264 rdf:type schema:CreativeWork
265 sg:pub.10.1186/1471-2148-7-30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034459120
266 https://doi.org/10.1186/1471-2148-7-30
267 rdf:type schema:CreativeWork
268 sg:pub.10.1186/1471-2164-13-525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031009486
269 https://doi.org/10.1186/1471-2164-13-525
270 rdf:type schema:CreativeWork
271 sg:pub.10.1186/1472-6807-10-34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031328011
272 https://doi.org/10.1186/1472-6807-10-34
273 rdf:type schema:CreativeWork
274 sg:pub.10.1186/1479-7364-4-1-59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036064711
275 https://doi.org/10.1186/1479-7364-4-1-59
276 rdf:type schema:CreativeWork
277 sg:pub.10.1186/gb-2010-11-7-r73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005615366
278 https://doi.org/10.1186/gb-2010-11-7-r73
279 rdf:type schema:CreativeWork
280 https://app.dimensions.ai/details/publication/pub.1077374000 schema:CreativeWork
281 https://app.dimensions.ai/details/publication/pub.1109368298 schema:CreativeWork
282 https://doi.org/10.1002/9780470475898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109368298
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.bbapap.2010.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042790849
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.bbapap.2010.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025769303
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.bbrc.2010.07.094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000460021
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.bbrc.2011.02.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003412510
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.jbiotec.2006.01.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039915282
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.tim.2007.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018845426
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/s0742-8413(98)10027-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029746602
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1021/cr9500500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011302001
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1074/jbc.m005617200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043400331
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1074/jbc.m809152200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044595461
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1074/jbc.r113.462275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042225024
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1093/bioinformatics/btl529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019858005
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1093/bioinformatics/btm404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007683223
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1093/gbe/evu132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020610574
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1093/molbev/msp077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028540883
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1093/molbev/msr121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049273973
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1093/nar/18.20.6097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041886714
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1093/nar/gkq1189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013912470
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1093/nar/gkt1183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047265540
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1093/nar/gkt1223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010707975
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1093/oxfordjournals.molbev.a040771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083487917
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1093/protein/gzt036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002098104
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1098/rstb.2012.0428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020638296
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1098/rstb.2012.0430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021983247
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1098/rstb.2012.0434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036288423
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1098/rstb.2012.0476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014680783
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1101/gr.849004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016890117
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1105/tpc.107.056663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043179727
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1111/j.1364-3703.2011.00754.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007488384
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1111/j.1469-8137.2009.02895.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024435774
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1126/science.1128796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043715710
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1126/science.1195203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062462742
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1128/aem.01195-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022777460
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1128/aem.03767-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021170559
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1128/ec.2.2.191-199.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042881206
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1371/journal.pcbi.1002195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001034143
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1371/journal.pgen.1003272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030475239
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1371/journal.pone.0075072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037478300
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1371/journal.pone.0086683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011461425
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1371/journal.pone.0095616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014270316
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1371/journal.pone.0107209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036753549
365 rdf:type schema:CreativeWork
366 https://doi.org/10.3852/13-002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017279706
367 rdf:type schema:CreativeWork
368 https://www.grid.ac/institutes/grid.14003.36 schema:alternateName University of Wisconsin–Madison
369 schema:name Department of Bacteriology, University of Wisconsin-Madison, 3155 MSB, 1550 Linden Drive, Madison WI 53706, USA.
370 rdf:type schema:Organization
371 https://www.grid.ac/institutes/grid.267301.1 schema:alternateName University of Tennessee Health Science Center
372 schema:name Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
373 rdf:type schema:Organization
374 https://www.grid.ac/institutes/grid.35155.37 schema:alternateName Huazhong Agricultural University
375 schema:name College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei Province, China.
376 rdf:type schema:Organization
377 https://www.grid.ac/institutes/grid.428369.2 schema:alternateName Central University of Technology
378 schema:name Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa.
379 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...