Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-09

AUTHORS

S W Jansen, A A Akintola, F Roelfsema, E van der Spoel, C M Cobbaert, B E Ballieux, P Egri, Z Kvarta-Papp, B Gereben, C Fekete, P E Slagboom, J van der Grond, B A Demeneix, H Pijl, R G J Westendorp, D van Heemst

ABSTRACT

Few studies have included subjects with the propensity to reach old age in good health, with the aim to disentangle mechanisms contributing to staying healthier for longer. The hypothalamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH) and thyroid hormone (TH) in an inverse relationship. Greater longevity has been associated with higher TSH and lower TH levels, but mechanisms underlying TSH/TH differences and longevity remain unknown. The HPT axis plays a pivotal role in growth, development and energy metabolism. We report that offspring of nonagenarians with at least one nonagenarian sibling have increased TSH secretion but similar bioactivity of TSH and similar TH levels compared to controls. Healthy offspring and spousal controls had similar resting metabolic rate and core body temperature. We propose that pleiotropic effects of the HPT axis may favour longevity without altering energy metabolism. More... »

PAGES

11525

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep11525

DOI

http://dx.doi.org/10.1038/srep11525

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038973146

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26089239


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