SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-06-04

AUTHORS

Masaki Akita, Yon-Soo Tak, Tsutomu Shimura, Syota Matsumoto, Yuki Okuda-Shimizu, Yuichiro Shimizu, Ryotaro Nishi, Hisato Saitoh, Shigenori Iwai, Toshio Mori, Tsuyoshi Ikura, Wataru Sakai, Fumio Hanaoka, Kaoru Sugasawa

ABSTRACT

The xeroderma pigmentosum group C (XPC) protein complex is a key factor that detects DNA damage and initiates nucleotide excision repair (NER) in mammalian cells. Although biochemical and structural studies have elucidated the interaction of XPC with damaged DNA, the mechanism of its regulation in vivo remains to be understood in more details. Here, we show that the XPC protein undergoes modification by small ubiquitin-related modifier (SUMO) proteins and the lack of this modification compromises the repair of UV-induced DNA photolesions. In the absence of SUMOylation, XPC is normally recruited to the sites with photolesions, but then immobilized profoundly by the UV-damaged DNA-binding protein (UV-DDB) complex. Since the absence of UV-DDB alleviates the NER defect caused by impaired SUMOylation of XPC, we propose that this modification is critical for functional interactions of XPC with UV-DDB, which facilitate the efficient damage handover between the two damage recognition factors and subsequent initiation of NER. More... »

PAGES

10984

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep10984

DOI

http://dx.doi.org/10.1038/srep10984

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005063638

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26042670


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "SUMO-1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sumoylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitin-Conjugating Enzymes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultraviolet Rays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, 657-8501, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, 657-8501, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akita", 
        "givenName": "Masaki", 
        "id": "sg:person.01015154116.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015154116.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, 657-8501, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, 657-8501, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tak", 
        "givenName": "Yon-Soo", 
        "id": "sg:person.01142626106.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142626106.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, 657-8501, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, 657-8501, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimura", 
        "givenName": "Tsutomu", 
        "id": "sg:person.01042674266.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042674266.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Graduate School of Science, Kobe University, 657-8501, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, 657-8501, Kobe, Japan", 
            "Graduate School of Science, Kobe University, 657-8501, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumoto", 
        "givenName": "Syota", 
        "id": "sg:person.01077500052.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077500052.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cellular Physiology Laboratory, RIKEN, 351-0198, Wako, Japan", 
          "id": "http://www.grid.ac/institutes/grid.7597.c", 
          "name": [
            "Cellular Physiology Laboratory, RIKEN, 351-0198, Wako, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okuda-Shimizu", 
        "givenName": "Yuki", 
        "id": "sg:person.0600544773.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600544773.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cellular Physiology Laboratory, RIKEN, 351-0198, Wako, Japan", 
          "id": "http://www.grid.ac/institutes/grid.7597.c", 
          "name": [
            "Cellular Physiology Laboratory, RIKEN, 351-0198, Wako, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimizu", 
        "givenName": "Yuichiro", 
        "id": "sg:person.01204425400.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204425400.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cellular Physiology Laboratory, RIKEN, 351-0198, Wako, Japan", 
          "id": "http://www.grid.ac/institutes/grid.7597.c", 
          "name": [
            "Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, 657-8501, Kobe, Japan", 
            "Cellular Physiology Laboratory, RIKEN, 351-0198, Wako, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishi", 
        "givenName": "Ryotaro", 
        "id": "sg:person.01107526426.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107526426.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Graduate School of Science and Technology, Kumamoto University, 860-8555, Kumamoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Graduate School of Science and Technology, Kumamoto University, 860-8555, Kumamoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saitoh", 
        "givenName": "Hisato", 
        "id": "sg:person.01000325453.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000325453.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Graduate School of Engineering Science, Osaka University, 560-8531, Toyonaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Graduate School of Engineering Science, Osaka University, 560-8531, Toyonaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iwai", 
        "givenName": "Shigenori", 
        "id": "sg:person.0727600052.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727600052.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radioisotope Research Center, Nara Medical University, 634-8521, Kashihara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410814.8", 
          "name": [
            "Radioisotope Research Center, Nara Medical University, 634-8521, Kashihara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mori", 
        "givenName": "Toshio", 
        "id": "sg:person.012034340311.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012034340311.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radiation Biology Center, Kyoto University, 606-8501, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Radiation Biology Center, Kyoto University, 606-8501, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ikura", 
        "givenName": "Tsuyoshi", 
        "id": "sg:person.0707142711.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707142711.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Graduate School of Science, Kobe University, 657-8501, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, 657-8501, Kobe, Japan", 
            "Graduate School of Science, Kobe University, 657-8501, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakai", 
        "givenName": "Wataru", 
        "id": "sg:person.01147410556.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147410556.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculty of Science, Gakushuin University, 171-8588, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.256169.f", 
          "name": [
            "Cellular Physiology Laboratory, RIKEN, 351-0198, Wako, Japan", 
            "Faculty of Science, Gakushuin University, 171-8588, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hanaoka", 
        "givenName": "Fumio", 
        "id": "sg:person.01177247732.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177247732.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cellular Physiology Laboratory, RIKEN, 351-0198, Wako, Japan", 
          "id": "http://www.grid.ac/institutes/grid.7597.c", 
          "name": [
            "Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, 657-8501, Kobe, Japan", 
            "Graduate School of Science, Kobe University, 657-8501, Kobe, Japan", 
            "Cellular Physiology Laboratory, RIKEN, 351-0198, Wako, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugasawa", 
        "givenName": "Kaoru", 
        "id": "sg:person.01063021332.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063021332.91"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10735-006-9044-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008965215", 
          "https://doi.org/10.1007/s10735-006-9044-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011375744", 
          "https://doi.org/10.1038/ncb2729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028207374", 
          "https://doi.org/10.1038/nrm3822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053628400", 
          "https://doi.org/10.1038/nsmb.2890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms4695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001709060", 
          "https://doi.org/10.1038/ncomms4695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025933337", 
          "https://doi.org/10.1038/nature06155"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-06-04", 
    "datePublishedReg": "2015-06-04", 
    "description": "The xeroderma pigmentosum group C (XPC) protein complex is a key factor that detects DNA damage and initiates nucleotide excision repair (NER) in mammalian cells. Although biochemical and structural studies have elucidated the interaction of XPC with damaged DNA, the mechanism of its regulation in vivo remains to be understood in more details. Here, we show that the XPC protein undergoes modification by small ubiquitin-related modifier (SUMO) proteins and the lack of this modification compromises the repair of UV-induced DNA photolesions. In the absence of SUMOylation, XPC is normally recruited to the sites with photolesions, but then immobilized profoundly by the UV-damaged DNA-binding protein (UV-DDB) complex. Since the absence of UV-DDB alleviates the NER defect caused by impaired SUMOylation of XPC, we propose that this modification is critical for functional interactions of XPC with UV-DDB, which facilitate the efficient damage handover between the two damage recognition factors and subsequent initiation of NER.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/srep10984", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5861605", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6135725", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6134813", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6033325", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5867004", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6149102", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5869219", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5873777", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6048895", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6157401", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "keywords": [
      "UV-DDB", 
      "protein complexes", 
      "xeroderma pigmentosum group C (XPC) protein complex", 
      "UV-damaged DNA-binding protein complex", 
      "excision repair", 
      "DNA-binding protein complex", 
      "xeroderma pigmentosum group C protein", 
      "small ubiquitin-related modifier (SUMO) proteins", 
      "UV-induced DNA photolesions", 
      "damage recognition factors", 
      "C protein complex", 
      "DNA damage recognition", 
      "absence of SUMOylation", 
      "nucleotide excision repair", 
      "modifier protein", 
      "XPC protein", 
      "NER defect", 
      "mammalian cells", 
      "damage recognition", 
      "C protein", 
      "SUMOylation", 
      "DNA damage", 
      "functional interaction", 
      "recognition factors", 
      "XPC", 
      "Impaired SUMOylation", 
      "protein", 
      "DNA photolesions", 
      "structural studies", 
      "photolesions", 
      "subsequent initiation", 
      "complexes", 
      "repair", 
      "DNA", 
      "regulation", 
      "modification", 
      "interaction", 
      "cells", 
      "absence", 
      "NER", 
      "vivo", 
      "sites", 
      "key factors", 
      "mechanism", 
      "more detail", 
      "initiation", 
      "factors", 
      "defects", 
      "damage", 
      "recognition", 
      "lack", 
      "study", 
      "detail", 
      "handover"
    ], 
    "name": "SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair", 
    "pagination": "10984", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005063638"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep10984"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26042670"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep10984", 
      "https://app.dimensions.ai/details/publication/pub.1005063638"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-10T10:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_680.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/srep10984"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep10984'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep10984'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep10984'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep10984'


 

This table displays all metadata directly associated to this object as RDF triples.

321 TRIPLES      22 PREDICATES      98 URIs      84 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep10984 schema:about N2ce54561177046318c41d78127f7999e
2 N2da09e6cd66042adbc716a9304e53db4
3 N4416390c9d5a4729a568d4845f81ad00
4 N492ebc41cf4f4870b752f41432c6d04b
5 N5b2be025a69a4b8296d964ed90472606
6 N7fb36a93329142de85eda31244798fe3
7 N822077a0880c41cabf7bf776f7cb3900
8 N9e70b2dce96d49579602f335594c4596
9 Nb97eb5bab0a046408cc0310efc5b9aa9
10 Nc31575f7ce294421967622e5b93cfd21
11 Ncda36ee474a243fc8c5cf177c7790869
12 Ne091019a300a4816a6c1ea5f3333f77c
13 anzsrc-for:06
14 anzsrc-for:0601
15 schema:author Nb4225b8647f942a3ab3288bda3c67a38
16 schema:citation sg:pub.10.1007/s10735-006-9044-7
17 sg:pub.10.1038/nature06155
18 sg:pub.10.1038/ncb2729
19 sg:pub.10.1038/ncomms4695
20 sg:pub.10.1038/nrm3822
21 sg:pub.10.1038/nsmb.2890
22 schema:datePublished 2015-06-04
23 schema:datePublishedReg 2015-06-04
24 schema:description The xeroderma pigmentosum group C (XPC) protein complex is a key factor that detects DNA damage and initiates nucleotide excision repair (NER) in mammalian cells. Although biochemical and structural studies have elucidated the interaction of XPC with damaged DNA, the mechanism of its regulation in vivo remains to be understood in more details. Here, we show that the XPC protein undergoes modification by small ubiquitin-related modifier (SUMO) proteins and the lack of this modification compromises the repair of UV-induced DNA photolesions. In the absence of SUMOylation, XPC is normally recruited to the sites with photolesions, but then immobilized profoundly by the UV-damaged DNA-binding protein (UV-DDB) complex. Since the absence of UV-DDB alleviates the NER defect caused by impaired SUMOylation of XPC, we propose that this modification is critical for functional interactions of XPC with UV-DDB, which facilitate the efficient damage handover between the two damage recognition factors and subsequent initiation of NER.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree true
28 schema:isPartOf N5bc8a4cbc4c84bdab36db7db86a2601e
29 Na7c080e0da324281867aae57df753b52
30 sg:journal.1045337
31 schema:keywords C protein
32 C protein complex
33 DNA
34 DNA damage
35 DNA damage recognition
36 DNA photolesions
37 DNA-binding protein complex
38 Impaired SUMOylation
39 NER
40 NER defect
41 SUMOylation
42 UV-DDB
43 UV-damaged DNA-binding protein complex
44 UV-induced DNA photolesions
45 XPC
46 XPC protein
47 absence
48 absence of SUMOylation
49 cells
50 complexes
51 damage
52 damage recognition
53 damage recognition factors
54 defects
55 detail
56 excision repair
57 factors
58 functional interaction
59 handover
60 initiation
61 interaction
62 key factors
63 lack
64 mammalian cells
65 mechanism
66 modification
67 modifier protein
68 more detail
69 nucleotide excision repair
70 photolesions
71 protein
72 protein complexes
73 recognition
74 recognition factors
75 regulation
76 repair
77 sites
78 small ubiquitin-related modifier (SUMO) proteins
79 structural studies
80 study
81 subsequent initiation
82 vivo
83 xeroderma pigmentosum group C (XPC) protein complex
84 xeroderma pigmentosum group C protein
85 schema:name SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair
86 schema:pagination 10984
87 schema:productId N122c1d86d98c4c1d8d3c1054003c79d3
88 N5cc24b0dd8ba4c1bad6604c72d72ed57
89 N60707636b4dc4b74a58acbc764148227
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005063638
91 https://doi.org/10.1038/srep10984
92 schema:sdDatePublished 2022-05-10T10:14
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher N1e4ee66335d14780b0287ef1788bd346
95 schema:url https://doi.org/10.1038/srep10984
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N020ce255aafe4715859099e3edff366b rdf:first sg:person.01142626106.08
100 rdf:rest Nc561df22201144cd8bc5de685227ef82
101 N104f27660c4a4602a1b82bd89a5101d0 rdf:first sg:person.012034340311.04
102 rdf:rest N13bd9edb96a74053ac2a124ad2cbbf14
103 N122c1d86d98c4c1d8d3c1054003c79d3 schema:name doi
104 schema:value 10.1038/srep10984
105 rdf:type schema:PropertyValue
106 N13bd9edb96a74053ac2a124ad2cbbf14 rdf:first sg:person.0707142711.07
107 rdf:rest Na5d92740726d4e68907090cde6fcf9b7
108 N1e4ee66335d14780b0287ef1788bd346 schema:name Springer Nature - SN SciGraph project
109 rdf:type schema:Organization
110 N1e85980ca6ff4552b60d7b476688f755 rdf:first sg:person.01177247732.44
111 rdf:rest N452ae7b41b6b4daa90d8fade4567a8e2
112 N2ce54561177046318c41d78127f7999e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name DNA Repair
114 rdf:type schema:DefinedTerm
115 N2da09e6cd66042adbc716a9304e53db4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Humans
117 rdf:type schema:DefinedTerm
118 N4416390c9d5a4729a568d4845f81ad00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Cell Line
120 rdf:type schema:DefinedTerm
121 N452ae7b41b6b4daa90d8fade4567a8e2 rdf:first sg:person.01063021332.91
122 rdf:rest rdf:nil
123 N492ebc41cf4f4870b752f41432c6d04b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name SUMO-1 Protein
125 rdf:type schema:DefinedTerm
126 N5b2be025a69a4b8296d964ed90472606 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Ubiquitination
128 rdf:type schema:DefinedTerm
129 N5bc8a4cbc4c84bdab36db7db86a2601e schema:issueNumber 1
130 rdf:type schema:PublicationIssue
131 N5cc24b0dd8ba4c1bad6604c72d72ed57 schema:name pubmed_id
132 schema:value 26042670
133 rdf:type schema:PropertyValue
134 N60707636b4dc4b74a58acbc764148227 schema:name dimensions_id
135 schema:value pub.1005063638
136 rdf:type schema:PropertyValue
137 N64f3fbaf680c42278607af6047df7158 rdf:first sg:person.01204425400.05
138 rdf:rest N6685633efd0644d6aadf7cfc53d17de6
139 N6685633efd0644d6aadf7cfc53d17de6 rdf:first sg:person.01107526426.51
140 rdf:rest N772e0c6fae9a4fc4857c4925fcd59b16
141 N772e0c6fae9a4fc4857c4925fcd59b16 rdf:first sg:person.01000325453.31
142 rdf:rest N789eab01704540f5b7238990c5da308a
143 N789eab01704540f5b7238990c5da308a rdf:first sg:person.0727600052.12
144 rdf:rest N104f27660c4a4602a1b82bd89a5101d0
145 N7fb36a93329142de85eda31244798fe3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Protein Binding
147 rdf:type schema:DefinedTerm
148 N822077a0880c41cabf7bf776f7cb3900 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name DNA-Binding Proteins
150 rdf:type schema:DefinedTerm
151 N97dafba29de04f549e4e516d12bb5d56 rdf:first sg:person.0600544773.21
152 rdf:rest N64f3fbaf680c42278607af6047df7158
153 N9e70b2dce96d49579602f335594c4596 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Sumoylation
155 rdf:type schema:DefinedTerm
156 Na5d92740726d4e68907090cde6fcf9b7 rdf:first sg:person.01147410556.51
157 rdf:rest N1e85980ca6ff4552b60d7b476688f755
158 Na7c080e0da324281867aae57df753b52 schema:volumeNumber 5
159 rdf:type schema:PublicationVolume
160 Nb4225b8647f942a3ab3288bda3c67a38 rdf:first sg:person.01015154116.72
161 rdf:rest N020ce255aafe4715859099e3edff366b
162 Nb97eb5bab0a046408cc0310efc5b9aa9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Mutation
164 rdf:type schema:DefinedTerm
165 Nc31575f7ce294421967622e5b93cfd21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Ubiquitin-Conjugating Enzymes
167 rdf:type schema:DefinedTerm
168 Nc561df22201144cd8bc5de685227ef82 rdf:first sg:person.01042674266.32
169 rdf:rest Ndc5e60b77d6f4c5999c18f34d6c4bdd0
170 Ncda36ee474a243fc8c5cf177c7790869 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Ultraviolet Rays
172 rdf:type schema:DefinedTerm
173 Ndc5e60b77d6f4c5999c18f34d6c4bdd0 rdf:first sg:person.01077500052.35
174 rdf:rest N97dafba29de04f549e4e516d12bb5d56
175 Ne091019a300a4816a6c1ea5f3333f77c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name DNA Damage
177 rdf:type schema:DefinedTerm
178 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
179 schema:name Biological Sciences
180 rdf:type schema:DefinedTerm
181 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
182 schema:name Biochemistry and Cell Biology
183 rdf:type schema:DefinedTerm
184 sg:grant.5861605 http://pending.schema.org/fundedItem sg:pub.10.1038/srep10984
185 rdf:type schema:MonetaryGrant
186 sg:grant.5867004 http://pending.schema.org/fundedItem sg:pub.10.1038/srep10984
187 rdf:type schema:MonetaryGrant
188 sg:grant.5869219 http://pending.schema.org/fundedItem sg:pub.10.1038/srep10984
189 rdf:type schema:MonetaryGrant
190 sg:grant.5873777 http://pending.schema.org/fundedItem sg:pub.10.1038/srep10984
191 rdf:type schema:MonetaryGrant
192 sg:grant.6033325 http://pending.schema.org/fundedItem sg:pub.10.1038/srep10984
193 rdf:type schema:MonetaryGrant
194 sg:grant.6048895 http://pending.schema.org/fundedItem sg:pub.10.1038/srep10984
195 rdf:type schema:MonetaryGrant
196 sg:grant.6134813 http://pending.schema.org/fundedItem sg:pub.10.1038/srep10984
197 rdf:type schema:MonetaryGrant
198 sg:grant.6135725 http://pending.schema.org/fundedItem sg:pub.10.1038/srep10984
199 rdf:type schema:MonetaryGrant
200 sg:grant.6149102 http://pending.schema.org/fundedItem sg:pub.10.1038/srep10984
201 rdf:type schema:MonetaryGrant
202 sg:grant.6157401 http://pending.schema.org/fundedItem sg:pub.10.1038/srep10984
203 rdf:type schema:MonetaryGrant
204 sg:journal.1045337 schema:issn 2045-2322
205 schema:name Scientific Reports
206 schema:publisher Springer Nature
207 rdf:type schema:Periodical
208 sg:person.01000325453.31 schema:affiliation grid-institutes:grid.274841.c
209 schema:familyName Saitoh
210 schema:givenName Hisato
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000325453.31
212 rdf:type schema:Person
213 sg:person.01015154116.72 schema:affiliation grid-institutes:grid.31432.37
214 schema:familyName Akita
215 schema:givenName Masaki
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015154116.72
217 rdf:type schema:Person
218 sg:person.01042674266.32 schema:affiliation grid-institutes:grid.31432.37
219 schema:familyName Shimura
220 schema:givenName Tsutomu
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042674266.32
222 rdf:type schema:Person
223 sg:person.01063021332.91 schema:affiliation grid-institutes:grid.7597.c
224 schema:familyName Sugasawa
225 schema:givenName Kaoru
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063021332.91
227 rdf:type schema:Person
228 sg:person.01077500052.35 schema:affiliation grid-institutes:grid.31432.37
229 schema:familyName Matsumoto
230 schema:givenName Syota
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077500052.35
232 rdf:type schema:Person
233 sg:person.01107526426.51 schema:affiliation grid-institutes:grid.7597.c
234 schema:familyName Nishi
235 schema:givenName Ryotaro
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107526426.51
237 rdf:type schema:Person
238 sg:person.01142626106.08 schema:affiliation grid-institutes:grid.31432.37
239 schema:familyName Tak
240 schema:givenName Yon-Soo
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142626106.08
242 rdf:type schema:Person
243 sg:person.01147410556.51 schema:affiliation grid-institutes:grid.31432.37
244 schema:familyName Sakai
245 schema:givenName Wataru
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147410556.51
247 rdf:type schema:Person
248 sg:person.01177247732.44 schema:affiliation grid-institutes:grid.256169.f
249 schema:familyName Hanaoka
250 schema:givenName Fumio
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177247732.44
252 rdf:type schema:Person
253 sg:person.012034340311.04 schema:affiliation grid-institutes:grid.410814.8
254 schema:familyName Mori
255 schema:givenName Toshio
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012034340311.04
257 rdf:type schema:Person
258 sg:person.01204425400.05 schema:affiliation grid-institutes:grid.7597.c
259 schema:familyName Shimizu
260 schema:givenName Yuichiro
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204425400.05
262 rdf:type schema:Person
263 sg:person.0600544773.21 schema:affiliation grid-institutes:grid.7597.c
264 schema:familyName Okuda-Shimizu
265 schema:givenName Yuki
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600544773.21
267 rdf:type schema:Person
268 sg:person.0707142711.07 schema:affiliation grid-institutes:grid.258799.8
269 schema:familyName Ikura
270 schema:givenName Tsuyoshi
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707142711.07
272 rdf:type schema:Person
273 sg:person.0727600052.12 schema:affiliation grid-institutes:grid.136593.b
274 schema:familyName Iwai
275 schema:givenName Shigenori
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727600052.12
277 rdf:type schema:Person
278 sg:pub.10.1007/s10735-006-9044-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008965215
279 https://doi.org/10.1007/s10735-006-9044-7
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/nature06155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025933337
282 https://doi.org/10.1038/nature06155
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/ncb2729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011375744
285 https://doi.org/10.1038/ncb2729
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/ncomms4695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001709060
288 https://doi.org/10.1038/ncomms4695
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/nrm3822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028207374
291 https://doi.org/10.1038/nrm3822
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/nsmb.2890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053628400
294 https://doi.org/10.1038/nsmb.2890
295 rdf:type schema:CreativeWork
296 grid-institutes:grid.136593.b schema:alternateName Graduate School of Engineering Science, Osaka University, 560-8531, Toyonaka, Japan
297 schema:name Graduate School of Engineering Science, Osaka University, 560-8531, Toyonaka, Japan
298 rdf:type schema:Organization
299 grid-institutes:grid.256169.f schema:alternateName Faculty of Science, Gakushuin University, 171-8588, Tokyo, Japan
300 schema:name Cellular Physiology Laboratory, RIKEN, 351-0198, Wako, Japan
301 Faculty of Science, Gakushuin University, 171-8588, Tokyo, Japan
302 rdf:type schema:Organization
303 grid-institutes:grid.258799.8 schema:alternateName Radiation Biology Center, Kyoto University, 606-8501, Kyoto, Japan
304 schema:name Radiation Biology Center, Kyoto University, 606-8501, Kyoto, Japan
305 rdf:type schema:Organization
306 grid-institutes:grid.274841.c schema:alternateName Graduate School of Science and Technology, Kumamoto University, 860-8555, Kumamoto, Japan
307 schema:name Graduate School of Science and Technology, Kumamoto University, 860-8555, Kumamoto, Japan
308 rdf:type schema:Organization
309 grid-institutes:grid.31432.37 schema:alternateName Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, 657-8501, Kobe, Japan
310 Graduate School of Science, Kobe University, 657-8501, Kobe, Japan
311 schema:name Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, 657-8501, Kobe, Japan
312 Graduate School of Science, Kobe University, 657-8501, Kobe, Japan
313 rdf:type schema:Organization
314 grid-institutes:grid.410814.8 schema:alternateName Radioisotope Research Center, Nara Medical University, 634-8521, Kashihara, Japan
315 schema:name Radioisotope Research Center, Nara Medical University, 634-8521, Kashihara, Japan
316 rdf:type schema:Organization
317 grid-institutes:grid.7597.c schema:alternateName Cellular Physiology Laboratory, RIKEN, 351-0198, Wako, Japan
318 schema:name Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, 657-8501, Kobe, Japan
319 Cellular Physiology Laboratory, RIKEN, 351-0198, Wako, Japan
320 Graduate School of Science, Kobe University, 657-8501, Kobe, Japan
321 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...