Quality of life is associated with chronic inflammation in schizophrenia: a cross-sectional study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-09

AUTHORS

Faugere M., Micoulaud-Franchi J.A., Alessandrini M., Richieri R., Faget-Agius C., Auquier P., Lançon C., Boyer L.

ABSTRACT

Inflammation may play a crucial role in the pathogenesis of schizophrenia. However, the association between chronic inflammation and health outcomes in schizophrenia remains unclear, particularly for patient-reported outcomes. The aim of this study was to investigate the relationship between quality of life (QoL) and chronic inflammation assessed using C -Reactive Protein (CRP) in patients with schizophrenia. Two hundred and fifty six patients with schizophrenia were enrolled in this study. After adjusting for key socio-demographic and clinical confounding factors, patients with high levels of CRP (>3.0 mg/l) had a lower QoL than patients with normal CRP levels (OR = 0.97, 95% CI = 0.94-0.99). An investigation of the dimensions of QoL revealed that psychological well-being, physical well-being and sentimental life were the most salient features of QoL associated with CRP. Significant associations were found between lower educational level (OR = 4.15, 95% CI = 1.55-11.07), higher body mass index (OR = 1.16, 95% CI = 1.06-1.28), higher Fagerström score (OR = 1.22, 95% CI = 1.01-1.47) and high levels of CRP. After replications with longitudinal approaches, the association between QoL and chronic inflammation may offer interesting interventional prospects to act both on inflammation and QoL in patients with schizophrenia. More... »

PAGES

10793

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep10793

DOI

http://dx.doi.org/10.1038/srep10793

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042521628

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26041435


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