The pluripotency factor NANOG promotes the formation of squamous cell carcinomas View Full Text


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Article Info

DATE

2015-05-19

AUTHORS

Adelaida R. Palla, Daniela Piazzolla, Noelia Alcazar, Marta Cañamero, Osvaldo Graña, Gonzalo Gómez-López, Orlando Dominguez, Marta Dueñas, Jesús M. Paramio, Manuel Serrano

ABSTRACT

NANOG is a key pluripotency factor in embryonic stem cells that is frequently expressed in squamous cell carcinomas (SCCs). However, a direct link between NANOG and SCCs remains to be established. Here, we show that inducible overexpression of NANOG in mouse skin epithelia favours the malignant conversion of skin papillomas induced by chemical carcinogenesis, leading to increased SCC formation. Gene expression analyses in pre-malignant skin indicate that NANOG induces genes associated to epithelial-mesenchymal transition (EMT). Some of these genes are directly activated by NANOG, including EMT-associated genes Zeb1, Zeb2, Twist1, Prrx1 and miR-21. Finally, endogenous NANOG binds to the promoters of theses genes in human SCC cells and, moreover, NANOG induces EMT features in primary keratinocytes. These results provide in vivo evidence for the oncogenic role of NANOG in squamous cell carcinomas. More... »

PAGES

10205

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep10205

    DOI

    http://dx.doi.org/10.1038/srep10205

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026408133

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25988972


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