Robo1/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-09

AUTHORS

Jiangchao Li, Yuxiang Ye, Renli Zhang, Lili Zhang, Xiwen Hu, Dong Han, Jiayuan Chen, Xiaodong He, Guang Wang, Xuesong Yang, Lijing Wang

ABSTRACT

Secreted Slit proteins and their Roundabout (Robo) receptors act as a repulsive cue to prevent axons from migrating to inappropriate locations during the development of the nervous system. Slit/Robo has also been implicated in reproductive system development, but the molecular mechanism of the Slit/Robo pathway in the reproductive system remains poorly understood. Using a transgenic mouse model, we investigated the function of the Slit/Robo pathway on ovarian follicle development and atresia. We first demonstrated that more offspring were born to mice with a partial knockout of the Robo1/2 genes in mice. We next showed that Robo1 and Robo2 are strongly expressed in ovarian granulosa cells. Apoptosis in granulosa cells was reduced when Robo1/2 were partially knocked out, and this observation was further verified by in vitro Robo1/2 knockout experiments in mouse and human granulosa cells. We also found that ovarian angiogenesis was enhanced by a partial lack of Robo1/2 genes. In summary, our data suggest that the Slit/Robo pathway can impact follicle development and atresia by influencing granulosa cell apoptosis. More... »

PAGES

9720

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep09720

DOI

http://dx.doi.org/10.1038/srep09720

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041927980

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25988316


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