A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-08

AUTHORS

Haruki Eguchi, Masanari Umemura, Reiko Kurotani, Hidenobu Fukumura, Itaru Sato, Jeong-Hwan Kim, Yujiro Hoshino, Jin Lee, Naoyuki Amemiya, Motohiko Sato, Kunio Hirata, David J. Singh, Takatsugu Masuda, Masahiro Yamamoto, Tsutomu Urano, Keiichiro Yoshida, Katsumi Tanigaki, Masaki Yamamoto, Mamoru Sato, Seiichi Inoue, Ichio Aoki, Yoshihiro Ishikawa

ABSTRACT

Research on controlled drug delivery for cancer chemotherapy has focused mainly on ways to deliver existing anti-cancer drug compounds to specified targets, e.g., by conjugating them with magnetic particles or encapsulating them in micelles. Here, we show that an iron-salen, i.e., μ-oxo N,N'- bis(salicylidene)ethylenediamine iron (Fe(Salen)), but not other metal salen derivatives, intrinsically exhibits both magnetic character and anti-cancer activity. X-Ray crystallographic analysis and first principles calculations based on the measured structure support this. It promoted apoptosis of various cancer cell lines, likely, via production of reactive oxygen species. In mouse leg tumor and tail melanoma models, Fe(Salen) delivery with magnet caused a robust decrease in tumor size, and the accumulation of Fe(Salen) was visualized by magnetic resonance imaging. Fe(Salen) is an anti-cancer compound with magnetic property, which is suitable for drug delivery and imaging. We believe such magnetic anti-cancer drugs have the potential to greatly advance cancer chemotherapy for new theranostics and drug-delivery strategies. More... »

PAGES

9194

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep09194

DOI

http://dx.doi.org/10.1038/srep09194

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051617930

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25779357


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Delivery Systems", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ethylenediamines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Iron", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetite Nanoparticles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Structure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "IHI Corporation (Japan)", 
          "id": "https://www.grid.ac/institutes/grid.454183.f", 
          "name": [
            "Cardiovascular Research Institute, Yokohama City University, Graduate School of Medicine, Yokohama, Japan", 
            "Advanced Applied Science Department, Research Laboratory, IHI Corporation, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eguchi", 
        "givenName": "Haruki", 
        "id": "sg:person.01265117003.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265117003.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yokohama City University", 
          "id": "https://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Cardiovascular Research Institute, Yokohama City University, Graduate School of Medicine, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Umemura", 
        "givenName": "Masanari", 
        "id": "sg:person.01112044367.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112044367.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yamagata University", 
          "id": "https://www.grid.ac/institutes/grid.268394.2", 
          "name": [
            "Biochemical Engineering, Faculty of Engineering, Yamagata University, Yonezawa, Yamagata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurotani", 
        "givenName": "Reiko", 
        "id": "sg:person.01064066263.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064066263.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of orthopedics, Machida Hospital, Machida, Tokyo"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukumura", 
        "givenName": "Hidenobu", 
        "id": "sg:person.0767511673.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767511673.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yokohama City University", 
          "id": "https://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Oral Surgery, Yokohama City University, Graduate School of Medicine, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Itaru", 
        "id": "sg:person.01261255703.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261255703.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Okinawa Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.250464.1", 
          "name": [
            "Cardiovascular Research Institute, Yokohama City University, Graduate School of Medicine, Yokohama, Japan", 
            "Nanoparticles by Design Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jeong-Hwan", 
        "id": "sg:person.0731220116.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731220116.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yokohama National University", 
          "id": "https://www.grid.ac/institutes/grid.268446.a", 
          "name": [
            "Department of Environment and Natural Sciences, Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoshino", 
        "givenName": "Yujiro", 
        "id": "sg:person.0741315000.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741315000.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yokohama City University", 
          "id": "https://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Radiology, Yokohama City University, Graduate School of Medicine, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Electrical Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amemiya", 
        "givenName": "Naoyuki", 
        "id": "sg:person.07474276013.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07474276013.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.411234.1", 
          "name": [
            "Department of Physiology, Aichi Medical University, Nagakute, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Motohiko", 
        "id": "sg:person.01305573607.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305573607.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RIKEN", 
          "id": "https://www.grid.ac/institutes/grid.7597.c", 
          "name": [
            "RIKEN, Research Infrastructure Group, SR Life Science Instrumentation Unit, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirata", 
        "givenName": "Kunio", 
        "id": "sg:person.01256470305.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256470305.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oak Ridge National Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.135519.a", 
          "name": [
            "Materials Science and Technology Division, Oak Ridge National Laboratory, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Singh", 
        "givenName": "David J.", 
        "id": "sg:person.0753316646.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753316646.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Tokyo Neutron Science Laboratory, Institute for Solid State Physics, the University of Tokyo, Shirakata, Tokai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masuda", 
        "givenName": "Takatsugu", 
        "id": "sg:person.0604511400.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604511400.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Konan University", 
          "id": "https://www.grid.ac/institutes/grid.258669.6", 
          "name": [
            "Department of Chemistry of Functional Molecules, Faculty of Science and Engineering, Konan University, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Masahiro", 
        "id": "sg:person.01257463662.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257463662.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yokohama City University", 
          "id": "https://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Yokohama City University, Graduate School, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Urano", 
        "givenName": "Tsutomu", 
        "id": "sg:person.01013711073.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013711073.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yokohama City University", 
          "id": "https://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Histology and Cell Biology, Yokohama City University School of Medicine, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Keiichiro", 
        "id": "sg:person.0746701613.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746701613.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tohoku University", 
          "id": "https://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "WPI-AIMR & Department of Physics, Graduate School of Science, Tohoku University, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanigaki", 
        "givenName": "Katsumi", 
        "id": "sg:person.01117665562.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117665562.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RIKEN", 
          "id": "https://www.grid.ac/institutes/grid.7597.c", 
          "name": [
            "RIKEN, Research Infrastructure Group, SR Life Science Instrumentation Unit, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Masaki", 
        "id": "sg:person.012771421304.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012771421304.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yokohama City University", 
          "id": "https://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Structural Biology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Mamoru", 
        "id": "sg:person.01216265317.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216265317.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yokohama National University", 
          "id": "https://www.grid.ac/institutes/grid.268446.a", 
          "name": [
            "Department of Environment and Natural Sciences, Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inoue", 
        "givenName": "Seiichi", 
        "id": "sg:person.07446554621.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07446554621.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Radiological Sciences", 
          "id": "https://www.grid.ac/institutes/grid.419638.1", 
          "name": [
            "Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoki", 
        "givenName": "Ichio", 
        "id": "sg:person.01172336045.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172336045.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yokohama City University", 
          "id": "https://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Cardiovascular Research Institute, Yokohama City University, Graduate School of Medicine, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishikawa", 
        "givenName": "Yoshihiro", 
        "id": "sg:person.01314600037.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314600037.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrd1632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001147838", 
          "https://doi.org/10.1038/nrd1632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd1632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001147838", 
          "https://doi.org/10.1038/nrd1632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/dt9960001229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001207960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0700776104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001727977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2009.202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004208062", 
          "https://doi.org/10.1038/nnano.2009.202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2009.202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004208062", 
          "https://doi.org/10.1038/nnano.2009.202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(97)76066-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004907170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2007.03.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007479197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1087057110385227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007562902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1087057110385227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007562902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0190-9622(94)70264-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008634770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1431927607081111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011722440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12576-012-0204-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013268040", 
          "https://doi.org/10.1007/s12576-012-0204-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12576-012-0204-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013268040", 
          "https://doi.org/10.1007/s12576-012-0204-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/212809a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013414355", 
          "https://doi.org/10.1038/212809a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/17435889.1.2.157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014300522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep02146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015592549", 
          "https://doi.org/10.1038/srep02146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physrevlett.89.167201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018019882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physrevlett.89.167201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018019882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0846.2007.00256.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019569945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020705083", 
          "https://doi.org/10.1038/nature06917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/923914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020850576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cc9800071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022053113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cc9800071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022053113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4155/bio.10.48", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022686760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10853-013-7968-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026239948", 
          "https://doi.org/10.1007/s10853-013-7968-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/0953-8984/14/11/301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026360594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cbin.10308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026523351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0108767307043930", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027786902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/27.21.4160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028237773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2004.10.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032406790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djk005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036377252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physrevlett.79.1337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038494442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physrevlett.79.1337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038494442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0010-8545(00)80384-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038530297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12576-014-0309-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043688592", 
          "https://doi.org/10.1007/s12576-014-0309-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12576-014-0309-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043688592", 
          "https://doi.org/10.1007/s12576-014-0309-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4314/tjpr.v12i2.20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044121146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4314/tjpr.v12i2.20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044121146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinorgbio.2007.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044170629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/lpor.201280022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045601199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2010.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048770078", 
          "https://doi.org/10.1038/nrclinonc.2010.139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2010.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048770078", 
          "https://doi.org/10.1038/nrclinonc.2010.139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.37.26217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048870567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/j19690001378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048894848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9783527627561.ch6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049327714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.apcatb.2006.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049401956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/erc-12-0285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052282842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ic00136a036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055544317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/om020959q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056272000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/1367-2630/15/12/125023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059136017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physrev.100.564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060416829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physrev.100.564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060416829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/20.718537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061117230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0846.2007.00256.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061948416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1615/critrevtherdrugcarriersyst.v15.i5.10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068133202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/187231309787158271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069225885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074739239", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075845373", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076917090", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079411780", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-08", 
    "datePublishedReg": "2015-08-01", 
    "description": "Research on controlled drug delivery for cancer chemotherapy has focused mainly on ways to deliver existing anti-cancer drug compounds to specified targets, e.g., by conjugating them with magnetic particles or encapsulating them in micelles. Here, we show that an iron-salen, i.e., \u03bc-oxo N,N'- bis(salicylidene)ethylenediamine iron (Fe(Salen)), but not other metal salen derivatives, intrinsically exhibits both magnetic character and anti-cancer activity. X-Ray crystallographic analysis and first principles calculations based on the measured structure support this. It promoted apoptosis of various cancer cell lines, likely, via production of reactive oxygen species. In mouse leg tumor and tail melanoma models, Fe(Salen) delivery with magnet caused a robust decrease in tumor size, and the accumulation of Fe(Salen) was visualized by magnetic resonance imaging. Fe(Salen) is an anti-cancer compound with magnetic property, which is suitable for drug delivery and imaging. We believe such magnetic anti-cancer drugs have the potential to greatly advance cancer chemotherapy for new theranostics and drug-delivery strategies. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep09194", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6158481", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6079006", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6082916", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6033064", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6111150", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6122383", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6107696", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6093756", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6089882", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging", 
    "pagination": "9194", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f5e1d04f4d8aaf21b873c017f4e3d5a5d838a3d513177f8b00ba8b114c856794"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25779357"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep09194"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051617930"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep09194", 
      "https://app.dimensions.ai/details/publication/pub.1051617930"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/srep09194"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep09194'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep09194'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep09194'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep09194'


 

This table displays all metadata directly associated to this object as RDF triples.

478 TRIPLES      21 PREDICATES      90 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep09194 schema:about N5c9c6da029ae4137a92b6f206f65405c
2 N61574f039e204b999c457d5648acbb14
3 N6f80e578e90d4dd1a7f2685ca343aebf
4 N78ff45b7df3742468810638eee4c0e5f
5 N81ff51ab2186431d89051bab6fe9aa00
6 N97e088e4d4444b72aeb0baffefb765d5
7 N9b5346169e9c43b5bf0f8fe277389672
8 Na3dbc51c7dcb47c79774e09631c3f4cc
9 Nae9da367f9b643a1a25ffbe882ae26e1
10 Naf76eecf4d6d4bd59b2de6bb3c8e9032
11 Nd50ad231ab8644119d29b287888c619a
12 Nd559702d4a8346ea8740b935b56d9174
13 anzsrc-for:11
14 anzsrc-for:1112
15 schema:author N503005f3c0b3445a976ae74be8897b01
16 schema:citation sg:pub.10.1007/s10853-013-7968-3
17 sg:pub.10.1007/s12576-012-0204-0
18 sg:pub.10.1007/s12576-014-0309-8
19 sg:pub.10.1038/212809a0
20 sg:pub.10.1038/nature06917
21 sg:pub.10.1038/nnano.2009.202
22 sg:pub.10.1038/nrclinonc.2010.139
23 sg:pub.10.1038/nrd1632
24 sg:pub.10.1038/srep02146
25 https://app.dimensions.ai/details/publication/pub.1074739239
26 https://app.dimensions.ai/details/publication/pub.1075845373
27 https://app.dimensions.ai/details/publication/pub.1076917090
28 https://app.dimensions.ai/details/publication/pub.1079411780
29 https://doi.org/10.1002/9783527627561.ch6
30 https://doi.org/10.1002/cbin.10308
31 https://doi.org/10.1002/lpor.201280022
32 https://doi.org/10.1016/j.apcatb.2006.03.008
33 https://doi.org/10.1016/j.biomaterials.2004.10.012
34 https://doi.org/10.1016/j.ccr.2007.03.009
35 https://doi.org/10.1016/j.jinorgbio.2007.11.008
36 https://doi.org/10.1016/s0010-8545(00)80384-7
37 https://doi.org/10.1016/s0076-6879(97)76066-x
38 https://doi.org/10.1016/s0190-9622(94)70264-0
39 https://doi.org/10.1017/s1431927607081111
40 https://doi.org/10.1021/cc9800071
41 https://doi.org/10.1021/ic00136a036
42 https://doi.org/10.1021/om020959q
43 https://doi.org/10.1039/dt9960001229
44 https://doi.org/10.1039/j19690001378
45 https://doi.org/10.1073/pnas.0700776104
46 https://doi.org/10.1074/jbc.274.37.26217
47 https://doi.org/10.1088/0953-8984/14/11/301
48 https://doi.org/10.1088/1367-2630/15/12/125023
49 https://doi.org/10.1093/jnci/djk005
50 https://doi.org/10.1093/nar/27.21.4160
51 https://doi.org/10.1103/physrev.100.564
52 https://doi.org/10.1103/physrevlett.79.1337
53 https://doi.org/10.1103/physrevlett.89.167201
54 https://doi.org/10.1107/s0108767307043930
55 https://doi.org/10.1109/20.718537
56 https://doi.org/10.1111/j.1600-0846.2007.00256.x
57 https://doi.org/10.1155/2012/923914
58 https://doi.org/10.1177/1087057110385227
59 https://doi.org/10.1530/erc-12-0285
60 https://doi.org/10.1615/critrevtherdrugcarriersyst.v15.i5.10
61 https://doi.org/10.2174/187231309787158271
62 https://doi.org/10.2217/17435889.1.2.157
63 https://doi.org/10.4155/bio.10.48
64 https://doi.org/10.4314/tjpr.v12i2.20
65 schema:datePublished 2015-08
66 schema:datePublishedReg 2015-08-01
67 schema:description Research on controlled drug delivery for cancer chemotherapy has focused mainly on ways to deliver existing anti-cancer drug compounds to specified targets, e.g., by conjugating them with magnetic particles or encapsulating them in micelles. Here, we show that an iron-salen, i.e., μ-oxo N,N'- bis(salicylidene)ethylenediamine iron (Fe(Salen)), but not other metal salen derivatives, intrinsically exhibits both magnetic character and anti-cancer activity. X-Ray crystallographic analysis and first principles calculations based on the measured structure support this. It promoted apoptosis of various cancer cell lines, likely, via production of reactive oxygen species. In mouse leg tumor and tail melanoma models, Fe(Salen) delivery with magnet caused a robust decrease in tumor size, and the accumulation of Fe(Salen) was visualized by magnetic resonance imaging. Fe(Salen) is an anti-cancer compound with magnetic property, which is suitable for drug delivery and imaging. We believe such magnetic anti-cancer drugs have the potential to greatly advance cancer chemotherapy for new theranostics and drug-delivery strategies.
68 schema:genre research_article
69 schema:inLanguage en
70 schema:isAccessibleForFree true
71 schema:isPartOf N0e7b347415a9435fad3402e33c6b2c51
72 Nce98202ce41a42bdade83d8ca7b48f81
73 sg:journal.1045337
74 schema:name A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging
75 schema:pagination 9194
76 schema:productId N473da30ea76e42f4846417a5501bdda3
77 Nb7c3b4c997054549ae12f54353f55070
78 Nd07dca4767254f648fa4a93d6642907b
79 Nde9956568cbb4bf5b5669014c0112291
80 Necc958cfa58846f78d25e3f97b3a1af2
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051617930
82 https://doi.org/10.1038/srep09194
83 schema:sdDatePublished 2019-04-10T23:12
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher N893754e3dfc94c348bc8517fe2aeaa69
86 schema:url http://www.nature.com/articles/srep09194
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N05e5d8c8fc784d749ba60508edab044d rdf:first sg:person.0746701613.15
91 rdf:rest N1c014adcdb4846bba34827ee32a7ed82
92 N0e7b347415a9435fad3402e33c6b2c51 schema:volumeNumber 5
93 rdf:type schema:PublicationVolume
94 N1c014adcdb4846bba34827ee32a7ed82 rdf:first sg:person.01117665562.07
95 rdf:rest N960bde9765e34d2fbb6e400368c240a1
96 N1cd9174aaeff446aa67a8d80eac7e4ef rdf:first sg:person.0767511673.99
97 rdf:rest N6ec56b9b7bfa4266a6b7b52b727621b6
98 N27837d601a294959a1ce1e361dcfb302 rdf:first sg:person.01305573607.10
99 rdf:rest N2be1c4e72a7c436c8cc62fdbe89f4310
100 N2be1c4e72a7c436c8cc62fdbe89f4310 rdf:first sg:person.01256470305.03
101 rdf:rest N3bddf9b18a87441bba91757e733642f6
102 N2fa586ec71344c049a9876b22dbaf76a rdf:first sg:person.07446554621.94
103 rdf:rest Nf4c86af7e3b741839f1f4e93570a7bfb
104 N3bddf9b18a87441bba91757e733642f6 rdf:first sg:person.0753316646.66
105 rdf:rest N7d03020b8f0c496c9d4d88050edde6ce
106 N460a9471946e4d94a513fd0da000e98d rdf:first sg:person.01314600037.22
107 rdf:rest rdf:nil
108 N473da30ea76e42f4846417a5501bdda3 schema:name readcube_id
109 schema:value f5e1d04f4d8aaf21b873c017f4e3d5a5d838a3d513177f8b00ba8b114c856794
110 rdf:type schema:PropertyValue
111 N4e69d9fe1a2546459d58600e3d928c33 rdf:first sg:person.0741315000.34
112 rdf:rest Nc6f5b94b61794922a32aef7d68596316
113 N503005f3c0b3445a976ae74be8897b01 rdf:first sg:person.01265117003.44
114 rdf:rest N91cd9ae6f2b245d49a35f365d600746e
115 N5c9c6da029ae4137a92b6f206f65405c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Antineoplastic Agents
117 rdf:type schema:DefinedTerm
118 N61574f039e204b999c457d5648acbb14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Molecular Structure
120 rdf:type schema:DefinedTerm
121 N6ec56b9b7bfa4266a6b7b52b727621b6 rdf:first sg:person.01261255703.55
122 rdf:rest Ne6d69feaeb69497cb545cc0c8c1318cc
123 N6f80e578e90d4dd1a7f2685ca343aebf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Drug Delivery Systems
125 rdf:type schema:DefinedTerm
126 N78ff45b7df3742468810638eee4c0e5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Ethylenediamines
128 rdf:type schema:DefinedTerm
129 N7bc2d16f8a5a485da2aaed15c5432841 schema:affiliation https://www.grid.ac/institutes/grid.268441.d
130 schema:familyName Lee
131 schema:givenName Jin
132 rdf:type schema:Person
133 N7d03020b8f0c496c9d4d88050edde6ce rdf:first sg:person.0604511400.44
134 rdf:rest Ne8ef38f419e245d3be7ddb411ecbc1af
135 N81ff51ab2186431d89051bab6fe9aa00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cell Line, Tumor
137 rdf:type schema:DefinedTerm
138 N891ae1de0a6f4802a7b7dfd26a52efc9 rdf:first sg:person.01216265317.75
139 rdf:rest N2fa586ec71344c049a9876b22dbaf76a
140 N893754e3dfc94c348bc8517fe2aeaa69 schema:name Springer Nature - SN SciGraph project
141 rdf:type schema:Organization
142 N908b441c99f84c80bcd2a1ca149c2961 rdf:first sg:person.01064066263.47
143 rdf:rest N1cd9174aaeff446aa67a8d80eac7e4ef
144 N91cd9ae6f2b245d49a35f365d600746e rdf:first sg:person.01112044367.05
145 rdf:rest N908b441c99f84c80bcd2a1ca149c2961
146 N960bde9765e34d2fbb6e400368c240a1 rdf:first sg:person.012771421304.81
147 rdf:rest N891ae1de0a6f4802a7b7dfd26a52efc9
148 N960f3f8aea554642a31b75e8d76a80e0 schema:name Department of orthopedics, Machida Hospital, Machida, Tokyo
149 rdf:type schema:Organization
150 N97e088e4d4444b72aeb0baffefb765d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Iron
152 rdf:type schema:DefinedTerm
153 N9b5346169e9c43b5bf0f8fe277389672 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Neoplasms
155 rdf:type schema:DefinedTerm
156 Na3dbc51c7dcb47c79774e09631c3f4cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Disease Models, Animal
158 rdf:type schema:DefinedTerm
159 Na42366abe8fe432daf084c5ae1bb6959 rdf:first sg:person.01013711073.39
160 rdf:rest N05e5d8c8fc784d749ba60508edab044d
161 Nae9da367f9b643a1a25ffbe882ae26e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Magnetic Resonance Imaging
163 rdf:type schema:DefinedTerm
164 Naf76eecf4d6d4bd59b2de6bb3c8e9032 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Animals
166 rdf:type schema:DefinedTerm
167 Nb7c3b4c997054549ae12f54353f55070 schema:name doi
168 schema:value 10.1038/srep09194
169 rdf:type schema:PropertyValue
170 Nc6f5b94b61794922a32aef7d68596316 rdf:first N7bc2d16f8a5a485da2aaed15c5432841
171 rdf:rest Ncd0f464bcb5a4e0499e638278b8b6d37
172 Ncd0f464bcb5a4e0499e638278b8b6d37 rdf:first sg:person.07474276013.36
173 rdf:rest N27837d601a294959a1ce1e361dcfb302
174 Nce98202ce41a42bdade83d8ca7b48f81 schema:issueNumber 1
175 rdf:type schema:PublicationIssue
176 Nd07dca4767254f648fa4a93d6642907b schema:name nlm_unique_id
177 schema:value 101563288
178 rdf:type schema:PropertyValue
179 Nd50ad231ab8644119d29b287888c619a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Magnetite Nanoparticles
181 rdf:type schema:DefinedTerm
182 Nd559702d4a8346ea8740b935b56d9174 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Mice
184 rdf:type schema:DefinedTerm
185 Nde9956568cbb4bf5b5669014c0112291 schema:name dimensions_id
186 schema:value pub.1051617930
187 rdf:type schema:PropertyValue
188 Ne6d69feaeb69497cb545cc0c8c1318cc rdf:first sg:person.0731220116.80
189 rdf:rest N4e69d9fe1a2546459d58600e3d928c33
190 Ne8ef38f419e245d3be7ddb411ecbc1af rdf:first sg:person.01257463662.68
191 rdf:rest Na42366abe8fe432daf084c5ae1bb6959
192 Necc958cfa58846f78d25e3f97b3a1af2 schema:name pubmed_id
193 schema:value 25779357
194 rdf:type schema:PropertyValue
195 Nf4c86af7e3b741839f1f4e93570a7bfb rdf:first sg:person.01172336045.33
196 rdf:rest N460a9471946e4d94a513fd0da000e98d
197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
198 schema:name Medical and Health Sciences
199 rdf:type schema:DefinedTerm
200 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
201 schema:name Oncology and Carcinogenesis
202 rdf:type schema:DefinedTerm
203 sg:grant.6033064 http://pending.schema.org/fundedItem sg:pub.10.1038/srep09194
204 rdf:type schema:MonetaryGrant
205 sg:grant.6079006 http://pending.schema.org/fundedItem sg:pub.10.1038/srep09194
206 rdf:type schema:MonetaryGrant
207 sg:grant.6082916 http://pending.schema.org/fundedItem sg:pub.10.1038/srep09194
208 rdf:type schema:MonetaryGrant
209 sg:grant.6089882 http://pending.schema.org/fundedItem sg:pub.10.1038/srep09194
210 rdf:type schema:MonetaryGrant
211 sg:grant.6093756 http://pending.schema.org/fundedItem sg:pub.10.1038/srep09194
212 rdf:type schema:MonetaryGrant
213 sg:grant.6107696 http://pending.schema.org/fundedItem sg:pub.10.1038/srep09194
214 rdf:type schema:MonetaryGrant
215 sg:grant.6111150 http://pending.schema.org/fundedItem sg:pub.10.1038/srep09194
216 rdf:type schema:MonetaryGrant
217 sg:grant.6122383 http://pending.schema.org/fundedItem sg:pub.10.1038/srep09194
218 rdf:type schema:MonetaryGrant
219 sg:grant.6158481 http://pending.schema.org/fundedItem sg:pub.10.1038/srep09194
220 rdf:type schema:MonetaryGrant
221 sg:journal.1045337 schema:issn 2045-2322
222 schema:name Scientific Reports
223 rdf:type schema:Periodical
224 sg:person.01013711073.39 schema:affiliation https://www.grid.ac/institutes/grid.268441.d
225 schema:familyName Urano
226 schema:givenName Tsutomu
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013711073.39
228 rdf:type schema:Person
229 sg:person.01064066263.47 schema:affiliation https://www.grid.ac/institutes/grid.268394.2
230 schema:familyName Kurotani
231 schema:givenName Reiko
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064066263.47
233 rdf:type schema:Person
234 sg:person.01112044367.05 schema:affiliation https://www.grid.ac/institutes/grid.268441.d
235 schema:familyName Umemura
236 schema:givenName Masanari
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112044367.05
238 rdf:type schema:Person
239 sg:person.01117665562.07 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
240 schema:familyName Tanigaki
241 schema:givenName Katsumi
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117665562.07
243 rdf:type schema:Person
244 sg:person.01172336045.33 schema:affiliation https://www.grid.ac/institutes/grid.419638.1
245 schema:familyName Aoki
246 schema:givenName Ichio
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172336045.33
248 rdf:type schema:Person
249 sg:person.01216265317.75 schema:affiliation https://www.grid.ac/institutes/grid.268441.d
250 schema:familyName Sato
251 schema:givenName Mamoru
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216265317.75
253 rdf:type schema:Person
254 sg:person.01256470305.03 schema:affiliation https://www.grid.ac/institutes/grid.7597.c
255 schema:familyName Hirata
256 schema:givenName Kunio
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256470305.03
258 rdf:type schema:Person
259 sg:person.01257463662.68 schema:affiliation https://www.grid.ac/institutes/grid.258669.6
260 schema:familyName Yamamoto
261 schema:givenName Masahiro
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257463662.68
263 rdf:type schema:Person
264 sg:person.01261255703.55 schema:affiliation https://www.grid.ac/institutes/grid.268441.d
265 schema:familyName Sato
266 schema:givenName Itaru
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261255703.55
268 rdf:type schema:Person
269 sg:person.01265117003.44 schema:affiliation https://www.grid.ac/institutes/grid.454183.f
270 schema:familyName Eguchi
271 schema:givenName Haruki
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265117003.44
273 rdf:type schema:Person
274 sg:person.012771421304.81 schema:affiliation https://www.grid.ac/institutes/grid.7597.c
275 schema:familyName Yamamoto
276 schema:givenName Masaki
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012771421304.81
278 rdf:type schema:Person
279 sg:person.01305573607.10 schema:affiliation https://www.grid.ac/institutes/grid.411234.1
280 schema:familyName Sato
281 schema:givenName Motohiko
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305573607.10
283 rdf:type schema:Person
284 sg:person.01314600037.22 schema:affiliation https://www.grid.ac/institutes/grid.268441.d
285 schema:familyName Ishikawa
286 schema:givenName Yoshihiro
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314600037.22
288 rdf:type schema:Person
289 sg:person.0604511400.44 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
290 schema:familyName Masuda
291 schema:givenName Takatsugu
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604511400.44
293 rdf:type schema:Person
294 sg:person.0731220116.80 schema:affiliation https://www.grid.ac/institutes/grid.250464.1
295 schema:familyName Kim
296 schema:givenName Jeong-Hwan
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731220116.80
298 rdf:type schema:Person
299 sg:person.0741315000.34 schema:affiliation https://www.grid.ac/institutes/grid.268446.a
300 schema:familyName Hoshino
301 schema:givenName Yujiro
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741315000.34
303 rdf:type schema:Person
304 sg:person.07446554621.94 schema:affiliation https://www.grid.ac/institutes/grid.268446.a
305 schema:familyName Inoue
306 schema:givenName Seiichi
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07446554621.94
308 rdf:type schema:Person
309 sg:person.0746701613.15 schema:affiliation https://www.grid.ac/institutes/grid.268441.d
310 schema:familyName Yoshida
311 schema:givenName Keiichiro
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746701613.15
313 rdf:type schema:Person
314 sg:person.07474276013.36 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
315 schema:familyName Amemiya
316 schema:givenName Naoyuki
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07474276013.36
318 rdf:type schema:Person
319 sg:person.0753316646.66 schema:affiliation https://www.grid.ac/institutes/grid.135519.a
320 schema:familyName Singh
321 schema:givenName David J.
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753316646.66
323 rdf:type schema:Person
324 sg:person.0767511673.99 schema:affiliation N960f3f8aea554642a31b75e8d76a80e0
325 schema:familyName Fukumura
326 schema:givenName Hidenobu
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767511673.99
328 rdf:type schema:Person
329 sg:pub.10.1007/s10853-013-7968-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026239948
330 https://doi.org/10.1007/s10853-013-7968-3
331 rdf:type schema:CreativeWork
332 sg:pub.10.1007/s12576-012-0204-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013268040
333 https://doi.org/10.1007/s12576-012-0204-0
334 rdf:type schema:CreativeWork
335 sg:pub.10.1007/s12576-014-0309-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043688592
336 https://doi.org/10.1007/s12576-014-0309-8
337 rdf:type schema:CreativeWork
338 sg:pub.10.1038/212809a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013414355
339 https://doi.org/10.1038/212809a0
340 rdf:type schema:CreativeWork
341 sg:pub.10.1038/nature06917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020705083
342 https://doi.org/10.1038/nature06917
343 rdf:type schema:CreativeWork
344 sg:pub.10.1038/nnano.2009.202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004208062
345 https://doi.org/10.1038/nnano.2009.202
346 rdf:type schema:CreativeWork
347 sg:pub.10.1038/nrclinonc.2010.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048770078
348 https://doi.org/10.1038/nrclinonc.2010.139
349 rdf:type schema:CreativeWork
350 sg:pub.10.1038/nrd1632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001147838
351 https://doi.org/10.1038/nrd1632
352 rdf:type schema:CreativeWork
353 sg:pub.10.1038/srep02146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015592549
354 https://doi.org/10.1038/srep02146
355 rdf:type schema:CreativeWork
356 https://app.dimensions.ai/details/publication/pub.1074739239 schema:CreativeWork
357 https://app.dimensions.ai/details/publication/pub.1075845373 schema:CreativeWork
358 https://app.dimensions.ai/details/publication/pub.1076917090 schema:CreativeWork
359 https://app.dimensions.ai/details/publication/pub.1079411780 schema:CreativeWork
360 https://doi.org/10.1002/9783527627561.ch6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049327714
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1002/cbin.10308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026523351
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1002/lpor.201280022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045601199
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1016/j.apcatb.2006.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049401956
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1016/j.biomaterials.2004.10.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032406790
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1016/j.ccr.2007.03.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007479197
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1016/j.jinorgbio.2007.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044170629
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1016/s0010-8545(00)80384-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038530297
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1016/s0076-6879(97)76066-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004907170
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1016/s0190-9622(94)70264-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008634770
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1017/s1431927607081111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011722440
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1021/cc9800071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022053113
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1021/ic00136a036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055544317
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1021/om020959q schema:sameAs https://app.dimensions.ai/details/publication/pub.1056272000
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1039/dt9960001229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001207960
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1039/j19690001378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048894848
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1073/pnas.0700776104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001727977
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1074/jbc.274.37.26217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048870567
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1088/0953-8984/14/11/301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026360594
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1088/1367-2630/15/12/125023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059136017
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1093/jnci/djk005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036377252
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1093/nar/27.21.4160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028237773
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1103/physrev.100.564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060416829
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1103/physrevlett.79.1337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038494442
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1103/physrevlett.89.167201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018019882
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1107/s0108767307043930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027786902
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1109/20.718537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061117230
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1111/j.1600-0846.2007.00256.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019569945
415 https://app.dimensions.ai/details/publication/pub.1061948416
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1155/2012/923914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020850576
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1177/1087057110385227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007562902
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1530/erc-12-0285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052282842
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1615/critrevtherdrugcarriersyst.v15.i5.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068133202
424 rdf:type schema:CreativeWork
425 https://doi.org/10.2174/187231309787158271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069225885
426 rdf:type schema:CreativeWork
427 https://doi.org/10.2217/17435889.1.2.157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014300522
428 rdf:type schema:CreativeWork
429 https://doi.org/10.4155/bio.10.48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022686760
430 rdf:type schema:CreativeWork
431 https://doi.org/10.4314/tjpr.v12i2.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044121146
432 rdf:type schema:CreativeWork
433 https://www.grid.ac/institutes/grid.135519.a schema:alternateName Oak Ridge National Laboratory
434 schema:name Materials Science and Technology Division, Oak Ridge National Laboratory, TN, USA
435 rdf:type schema:Organization
436 https://www.grid.ac/institutes/grid.250464.1 schema:alternateName Okinawa Institute of Science and Technology
437 schema:name Cardiovascular Research Institute, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
438 Nanoparticles by Design Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Japan
439 rdf:type schema:Organization
440 https://www.grid.ac/institutes/grid.258669.6 schema:alternateName Konan University
441 schema:name Department of Chemistry of Functional Molecules, Faculty of Science and Engineering, Konan University, Kobe, Japan
442 rdf:type schema:Organization
443 https://www.grid.ac/institutes/grid.258799.8 schema:alternateName Kyoto University
444 schema:name Department of Electrical Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan
445 rdf:type schema:Organization
446 https://www.grid.ac/institutes/grid.268394.2 schema:alternateName Yamagata University
447 schema:name Biochemical Engineering, Faculty of Engineering, Yamagata University, Yonezawa, Yamagata, Japan
448 rdf:type schema:Organization
449 https://www.grid.ac/institutes/grid.268441.d schema:alternateName Yokohama City University
450 schema:name Cardiovascular Research Institute, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
451 Department of Histology and Cell Biology, Yokohama City University School of Medicine, Yokohama, Japan
452 Department of Oral Surgery, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
453 Department of Radiology, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
454 Structural Biology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan
455 Yokohama City University, Graduate School, Yokohama, Japan
456 rdf:type schema:Organization
457 https://www.grid.ac/institutes/grid.268446.a schema:alternateName Yokohama National University
458 schema:name Department of Environment and Natural Sciences, Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama, Japan
459 rdf:type schema:Organization
460 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
461 schema:name Tokyo Neutron Science Laboratory, Institute for Solid State Physics, the University of Tokyo, Shirakata, Tokai, Japan
462 rdf:type schema:Organization
463 https://www.grid.ac/institutes/grid.411234.1 schema:alternateName Aichi Medical University
464 schema:name Department of Physiology, Aichi Medical University, Nagakute, Aichi, Japan
465 rdf:type schema:Organization
466 https://www.grid.ac/institutes/grid.419638.1 schema:alternateName National Institute of Radiological Sciences
467 schema:name Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
468 rdf:type schema:Organization
469 https://www.grid.ac/institutes/grid.454183.f schema:alternateName IHI Corporation (Japan)
470 schema:name Advanced Applied Science Department, Research Laboratory, IHI Corporation, Yokohama, Japan
471 Cardiovascular Research Institute, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
472 rdf:type schema:Organization
473 https://www.grid.ac/institutes/grid.69566.3a schema:alternateName Tohoku University
474 schema:name WPI-AIMR & Department of Physics, Graduate School of Science, Tohoku University, Sendai, Japan
475 rdf:type schema:Organization
476 https://www.grid.ac/institutes/grid.7597.c schema:alternateName RIKEN
477 schema:name RIKEN, Research Infrastructure Group, SR Life Science Instrumentation Unit, Hyogo, Japan
478 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...