Repair of spinal cord injury by implantation of bFGF-incorporated HEMA-MOETACL hydrogel in rats View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-03-12

AUTHORS

Bo Chen, Jianyu He, Hao Yang, Qian Zhang, Lingling Zhang, Xian Zhang, En Xie, Cuicui Liu, Rui Zhang, Yi Wang, Linhong Huang, Dingjun Hao

ABSTRACT

There is no effective strategy for the treatment of spinal cord injury (SCI). An appropriate combination of hydrogel materials and neurotrophic factor therapy is currently thought to be a promising approach. In this study, we performed experiments to evaluate the synergic effect of implanting hydroxyl ethyl methacrylate [2-(methacryloyloxy)ethyl] trimethylammonium chloride (HEMA-MOETACL) hydrogel incorporated with basic fibroblast growth factor (bFGF) into the site of surgically induced SCI. Prior to implantation, the combined hydrogel was surrounded by an acellular vascular matrix. Sprague-Dawley rats underwent complete spinal cord transection at the T-9 level, followed by implantation of bFGF/HEMA-MOETACL 5 days after transection surgery. Our results showed that the bFGF/HEMA-MOETACL transplant provided a scaffold for the ingrowth of regenerating tissue eight weeks after implantation. Furthermore, this newly designed implant promoted both nerve tissue regeneration and functional recovery following SCI. These results indicate that HEMA-MOETACL hydrogel is a promising scaffold for intrathecal, localized and sustained delivery of bFGF to the injured spinal cord and provide evidence for the possibility that this approach may have clinical applications in the treatment of SCI. More... »

PAGES

9017

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep09017

DOI

http://dx.doi.org/10.1038/srep09017

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039443277

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25761585


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31 schema:description There is no effective strategy for the treatment of spinal cord injury (SCI). An appropriate combination of hydrogel materials and neurotrophic factor therapy is currently thought to be a promising approach. In this study, we performed experiments to evaluate the synergic effect of implanting hydroxyl ethyl methacrylate [2-(methacryloyloxy)ethyl] trimethylammonium chloride (HEMA-MOETACL) hydrogel incorporated with basic fibroblast growth factor (bFGF) into the site of surgically induced SCI. Prior to implantation, the combined hydrogel was surrounded by an acellular vascular matrix. Sprague-Dawley rats underwent complete spinal cord transection at the T-9 level, followed by implantation of bFGF/HEMA-MOETACL 5 days after transection surgery. Our results showed that the bFGF/HEMA-MOETACL transplant provided a scaffold for the ingrowth of regenerating tissue eight weeks after implantation. Furthermore, this newly designed implant promoted both nerve tissue regeneration and functional recovery following SCI. These results indicate that HEMA-MOETACL hydrogel is a promising scaffold for intrathecal, localized and sustained delivery of bFGF to the injured spinal cord and provide evidence for the possibility that this approach may have clinical applications in the treatment of SCI.
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38 schema:keywords HEMA-MOETACL 5 days
39 HEMA-MOETACL hydrogel
40 HEMA-MOETACL transplant
41 Sprague-Dawley rats
42 acellular vascular matrix
43 applications
44 approach
45 appropriate combination
46 bFGF/HEMA-MOETACL 5 days
47 bFGF/HEMA-MOETACL transplant
48 basic fibroblast growth factor
49 chloride (HEMA-MOETACL) hydrogel
50 clinical applications
51 combination
52 combined hydrogel
53 complete spinal cord transection
54 cord
55 cord injury
56 cord transection
57 days
58 delivery
59 effect
60 effective strategy
61 eight weeks
62 ethyl methacrylate [2-(methacryloyloxy)ethyl] trimethylammonium chloride (HEMA-MOETACL) hydrogel
63 evidence
64 experiments
65 factor therapy
66 factors
67 fibroblast growth factor
68 functional recovery
69 growth factor
70 hydrogel materials
71 hydrogels
72 hydroxyl ethyl methacrylate [2-(methacryloyloxy)ethyl] trimethylammonium chloride (HEMA-MOETACL) hydrogel
73 implantation
74 implantation of bFGF
75 ingrowth
76 injury
77 levels
78 materials
79 matrix
80 methacrylate [2-(methacryloyloxy)ethyl] trimethylammonium chloride (HEMA-MOETACL) hydrogel
81 nerve tissue regeneration
82 neurotrophic factor therapy
83 possibility
84 promising approach
85 promising scaffold
86 rats
87 recovery
88 regenerating tissue eight weeks
89 regeneration
90 repair
91 results
92 scaffolds
93 sites
94 spinal cord
95 spinal cord injury
96 spinal cord transection
97 strategies
98 study
99 surgery
100 sustained delivery
101 synergic effect
102 therapy
103 tissue eight weeks
104 tissue regeneration
105 transection
106 transection surgery
107 transplant
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110 trimethylammonium chloride (HEMA-MOETACL) hydrogel
111 vascular matrix
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