A monomer-trimer model supports intermittent glucagon fibril growth View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-08

AUTHORS

Andrej Košmrlj, Pia Cordsen, Anders Kyrsting, Daniel E. Otzen, Lene B. Oddershede, Mogens H. Jensen

ABSTRACT

We investigate in vitro fibrillation kinetics of the hormone peptide glucagon at various concentrations using confocal microscopy and determine the glucagon fibril persistence length 60μm. At all concentrations we observe that periods of individual fibril growth are interrupted by periods of stasis. The growth probability is large at high and low concentrations and is reduced for intermediate glucagon concentrations. To explain this behavior we propose a simple model, where fibrils come in two forms, one built entirely from glucagon monomers and one entirely from glucagon trimers. The opposite building blocks act as fibril growth blockers, and this generic model reproduces experimental behavior well. More... »

PAGES

9005

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep09005

DOI

http://dx.doi.org/10.1038/srep09005

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042097648

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25758791


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