Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-07

AUTHORS

Weiwei Jiang, Na Wu, Xuemei Wang, Yujing Chi, Yuanyuan Zhang, Xinyun Qiu, Ying Hu, Jing Li, Yulan Liu

ABSTRACT

Non-alcoholic fatty liver disease (NAFLD) has recently been considered to be under the influence of the gut microbiota, which might exert toxic effects on the human host after intestinal absorption and delivery to the liver via the portal vein. In this study, the composition of the gut microbiota in NAFLD patients and healthy subjects was determined via 16S ribosomal RNA Illumina next-generation sequencing. Among those taxa displaying greater than 0.1% average abundance in all samples, five genera, including Alistipes and Prevotella, were significantly more abundant in the gut microbiota of healthy subjects compared to NAFLD patients. Alternatively, Escherichia, Anaerobacter, Lactobacillus and Streptococcus were increased in the gut microbiota of NAFLD patients compared to healthy subjects. In addition, decreased numbers of CD4+ and CD8+ T lymphocytes and increased levels of TNF-α, IL-6 and IFN-γ were detected in the NAFLD group compared to the healthy group. Furthermore, irregularly arranged microvilli and widened tight junctions were observed in the gut mucosa of the NAFLD patients via transmission electron microscopy. We postulate that aside from dysbiosis of the gut microbiota, gut microbiota-mediated inflammation of the intestinal mucosa and the related impairment in mucosal immune function play an important role in the pathogenesis of NAFLD. More... »

PAGES

8096

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep08096

DOI

http://dx.doi.org/10.1038/srep08096

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052381018

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25644696


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacteria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD8-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Sectional Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dysbiosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-gamma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Mucosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microbiota", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Non-alcoholic Fatty Liver Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Ribosomal, 16S", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, RNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tight Junctions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Peking University People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411634.5", 
          "name": [
            "Department of Gastroenterology, Peking University People's Hospital, Beijing, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jiang", 
        "givenName": "Weiwei", 
        "id": "sg:person.0661211444.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661211444.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411634.5", 
          "name": [
            "Institute of Clinical Molecular Biology &Central Laboratory, Peking University People's Hospital, Beijing, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Na", 
        "id": "sg:person.01146433570.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146433570.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411634.5", 
          "name": [
            "Department of Gastroenterology, Peking University People's Hospital, Beijing, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Xuemei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411634.5", 
          "name": [
            "Institute of Clinical Molecular Biology &Central Laboratory, Peking University People's Hospital, Beijing, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chi", 
        "givenName": "Yujing", 
        "id": "sg:person.0740232777.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740232777.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411634.5", 
          "name": [
            "Department of Gastroenterology, Peking University People's Hospital, Beijing, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Yuanyuan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411634.5", 
          "name": [
            "Department of Gastroenterology, Peking University People's Hospital, Beijing, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qiu", 
        "givenName": "Xinyun", 
        "id": "sg:person.01160001644.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160001644.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411634.5", 
          "name": [
            "Department of Gastroenterology, Peking University People's Hospital, Beijing, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Ying", 
        "id": "sg:person.01226115044.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226115044.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411634.5", 
          "name": [
            "Department of Gastroenterology, Peking University People's Hospital, Beijing, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Jing", 
        "id": "sg:person.01242370164.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242370164.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411634.5", 
          "name": [
            "Department of Gastroenterology, Peking University People's Hospital, Beijing, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Yulan", 
        "id": "sg:person.01100320370.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100320370.44"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ncomms2957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003904764", 
          "https://doi.org/10.1038/ncomms2957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.2012.12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006175048", 
          "https://doi.org/10.1038/labinvest.2012.12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cgh.2012.03.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007062492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000228558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007682066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmrr.2518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008370904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.numecd.2012.02.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009877370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1223490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009915545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1208344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015324311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2005.11.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015555085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/oby.2008.55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017880760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tem.2013.05.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019928617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1005963107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023427228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023893418", 
          "https://doi.org/10.1038/nature05414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023893418", 
          "https://doi.org/10.1038/nature05414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023893418", 
          "https://doi.org/10.1038/nature05414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cgh.2013.02.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028488484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrgastro.2010.172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030043163", 
          "https://doi.org/10.1038/nrgastro.2010.172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrgastro.2010.172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030043163", 
          "https://doi.org/10.1038/nrgastro.2010.172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2265.2001.1139cn2155.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035818308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2265.2001.1139cn2155.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035818308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.24001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036889282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.24001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036889282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.26319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037068058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.26093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037397249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2010/453563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039981882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2012.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040397736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2008.165886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041802749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3083.2011.02613.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044712949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2013-304739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044827876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/gmic.19625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045196658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1001261107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045609563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro1817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046322683", 
          "https://doi.org/10.1038/nrmicro1817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2012-303816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051857426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00075197-200409000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053556038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00075197-200409000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053556038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2265.2001.1139/cn2155.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056734311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1381612811319290011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069169112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078352251", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078520589", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082542940", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082736674", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-07", 
    "datePublishedReg": "2015-07-01", 
    "description": "Non-alcoholic fatty liver disease (NAFLD) has recently been considered to be under the influence of the gut microbiota, which might exert toxic effects on the human host after intestinal absorption and delivery to the liver via the portal vein. In this study, the composition of the gut microbiota in NAFLD patients and healthy subjects was determined via 16S ribosomal RNA Illumina next-generation sequencing. Among those taxa displaying greater than 0.1% average abundance in all samples, five genera, including Alistipes and Prevotella, were significantly more abundant in the gut microbiota of healthy subjects compared to NAFLD patients. Alternatively, Escherichia, Anaerobacter, Lactobacillus and Streptococcus were increased in the gut microbiota of NAFLD patients compared to healthy subjects. In addition, decreased numbers of CD4+ and CD8+ T lymphocytes and increased levels of TNF-\u03b1, IL-6 and IFN-\u03b3 were detected in the NAFLD group compared to the healthy group. Furthermore, irregularly arranged microvilli and widened tight junctions were observed in the gut mucosa of the NAFLD patients via transmission electron microscopy. We postulate that aside from dysbiosis of the gut microbiota, gut microbiota-mediated inflammation of the intestinal mucosa and the related impairment in mucosal immune function play an important role in the pathogenesis of NAFLD. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep08096", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease", 
    "pagination": "8096", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f98228960b6675e2b1b71b5c26c6dd07b4aed302c837bf0ceb3bcdf94c15a877"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25644696"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep08096"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052381018"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep08096", 
      "https://app.dimensions.ai/details/publication/pub.1052381018"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T12:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2015/150203/srep08096/full/srep08096.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep08096'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep08096'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep08096'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep08096'


 

This table displays all metadata directly associated to this object as RDF triples.

313 TRIPLES      21 PREDICATES      85 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep08096 schema:about N0884a2b92f6249b1839f6fc8988bd895
2 N0be99e3f1c104675858e62d0a20dfadd
3 N115a690a92aa4927a301a0363b5c9a6e
4 N1ca11b08b08c44278d3a8ffc36a5678a
5 N1fd5a8bb73714136b6d30341ea43c2cf
6 N2a719a6613104c9faadac56cecdde570
7 N3016726401704f76b37a4de7f2b09eea
8 N3863684bf59443cfa057dd3aae72503a
9 N3926fc9cdb2341858356e2e954413088
10 N51f1f30ad308494c8ba0344e971a6635
11 N649f61e0cdf8482cb061b8c50b329bc1
12 N6a1129bb28ec4d98acf4f705ea2bca32
13 Nb3d414e98e0e4a9b925a3daacc922ebe
14 Ncc63faf2fedc4eb5bfea3c629b823ff8
15 Nccddb53aa38a47e595a7ac999cf2f20a
16 Nd5079076618249ee8b4ad9b041887c19
17 Ndb3e38c8562a4869804a2c625d86cdad
18 Ndeefd99517ac439d82d553addf0d86cd
19 Ne28579113d7648baafcc05b83289897a
20 Nec875895a9a24cfd951793abf67bc8f2
21 Nfc1cfcfb3e8b48b0bb1a3c6143a7841d
22 anzsrc-for:11
23 anzsrc-for:1103
24 schema:author Nc9d5bf72683e4758974c6405463782cc
25 schema:citation sg:pub.10.1038/labinvest.2012.12
26 sg:pub.10.1038/nature05414
27 sg:pub.10.1038/ncomms2957
28 sg:pub.10.1038/nrgastro.2010.172
29 sg:pub.10.1038/nrmicro1817
30 https://app.dimensions.ai/details/publication/pub.1078352251
31 https://app.dimensions.ai/details/publication/pub.1078520589
32 https://app.dimensions.ai/details/publication/pub.1082542940
33 https://app.dimensions.ai/details/publication/pub.1082736674
34 https://doi.org/10.1002/dmrr.2518
35 https://doi.org/10.1002/hep.24001
36 https://doi.org/10.1002/hep.26093
37 https://doi.org/10.1002/hep.26319
38 https://doi.org/10.1016/j.cgh.2012.03.011
39 https://doi.org/10.1016/j.cgh.2013.02.015
40 https://doi.org/10.1016/j.numecd.2012.02.007
41 https://doi.org/10.1016/j.tem.2013.05.009
42 https://doi.org/10.1038/oby.2008.55
43 https://doi.org/10.1046/j.1365-2265.2001.1139/cn2155.x
44 https://doi.org/10.1046/j.1365-2265.2001.1139cn2155.x
45 https://doi.org/10.1053/j.gastro.2005.11.048
46 https://doi.org/10.1053/j.gastro.2012.04.001
47 https://doi.org/10.1073/pnas.1001261107
48 https://doi.org/10.1073/pnas.1005963107
49 https://doi.org/10.1097/00075197-200409000-00009
50 https://doi.org/10.1111/j.1365-3083.2011.02613.x
51 https://doi.org/10.1126/science.1208344
52 https://doi.org/10.1126/science.1223490
53 https://doi.org/10.1136/gut.2008.165886
54 https://doi.org/10.1136/gutjnl-2012-303816
55 https://doi.org/10.1136/gutjnl-2013-304739
56 https://doi.org/10.1155/2010/453563
57 https://doi.org/10.1159/000228558
58 https://doi.org/10.2174/1381612811319290011
59 https://doi.org/10.4161/gmic.19625
60 schema:datePublished 2015-07
61 schema:datePublishedReg 2015-07-01
62 schema:description Non-alcoholic fatty liver disease (NAFLD) has recently been considered to be under the influence of the gut microbiota, which might exert toxic effects on the human host after intestinal absorption and delivery to the liver via the portal vein. In this study, the composition of the gut microbiota in NAFLD patients and healthy subjects was determined via 16S ribosomal RNA Illumina next-generation sequencing. Among those taxa displaying greater than 0.1% average abundance in all samples, five genera, including Alistipes and Prevotella, were significantly more abundant in the gut microbiota of healthy subjects compared to NAFLD patients. Alternatively, Escherichia, Anaerobacter, Lactobacillus and Streptococcus were increased in the gut microbiota of NAFLD patients compared to healthy subjects. In addition, decreased numbers of CD4+ and CD8+ T lymphocytes and increased levels of TNF-α, IL-6 and IFN-γ were detected in the NAFLD group compared to the healthy group. Furthermore, irregularly arranged microvilli and widened tight junctions were observed in the gut mucosa of the NAFLD patients via transmission electron microscopy. We postulate that aside from dysbiosis of the gut microbiota, gut microbiota-mediated inflammation of the intestinal mucosa and the related impairment in mucosal immune function play an important role in the pathogenesis of NAFLD.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree true
66 schema:isPartOf N6523ba0807c644f88b9fb0004d869b18
67 N76e4a5b128244d78bae5c94a63689251
68 sg:journal.1045337
69 schema:name Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease
70 schema:pagination 8096
71 schema:productId N72243935821747c2a0b461069ee60ed3
72 N9c60ea4d7b6344b794fa60791fceb73a
73 Na194cba4262949e6854a752da06ed99f
74 Na3fc49429cc54f54b34837de611eb351
75 Nd6066359cf744f20b51aa330d68ae2c1
76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052381018
77 https://doi.org/10.1038/srep08096
78 schema:sdDatePublished 2019-04-10T12:59
79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
80 schema:sdPublisher N8fcfae7b26494904ab2947e17f828527
81 schema:url http://www.nature.com/srep/2015/150203/srep08096/full/srep08096.html
82 sgo:license sg:explorer/license/
83 sgo:sdDataset articles
84 rdf:type schema:ScholarlyArticle
85 N0884a2b92f6249b1839f6fc8988bd895 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Adult
87 rdf:type schema:DefinedTerm
88 N0be99e3f1c104675858e62d0a20dfadd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Tight Junctions
90 rdf:type schema:DefinedTerm
91 N115a690a92aa4927a301a0363b5c9a6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Bacteria
93 rdf:type schema:DefinedTerm
94 N1a5144a5c02b4815af3d7a4c524522d8 rdf:first sg:person.01226115044.99
95 rdf:rest Nfa27ee86b6c94cf5b50cd57120ecb48a
96 N1ca11b08b08c44278d3a8ffc36a5678a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Aged
98 rdf:type schema:DefinedTerm
99 N1f6893fecb4b442bbbf06dcd0477c30a schema:affiliation https://www.grid.ac/institutes/grid.411634.5
100 schema:familyName Zhang
101 schema:givenName Yuanyuan
102 rdf:type schema:Person
103 N1fd5a8bb73714136b6d30341ea43c2cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name CD8-Positive T-Lymphocytes
105 rdf:type schema:DefinedTerm
106 N24f0e9d342944d6cb4aa99591d19e96e rdf:first sg:person.0740232777.17
107 rdf:rest N6c201bba4ca54a9f98568e2db987af27
108 N2a719a6613104c9faadac56cecdde570 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Microbiota
110 rdf:type schema:DefinedTerm
111 N3016726401704f76b37a4de7f2b09eea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Non-alcoholic Fatty Liver Disease
113 rdf:type schema:DefinedTerm
114 N3863684bf59443cfa057dd3aae72503a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Dysbiosis
116 rdf:type schema:DefinedTerm
117 N3926fc9cdb2341858356e2e954413088 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Sequence Analysis, RNA
119 rdf:type schema:DefinedTerm
120 N3b5a80571b26416db82914caa581ba68 schema:affiliation https://www.grid.ac/institutes/grid.411634.5
121 schema:familyName Wang
122 schema:givenName Xuemei
123 rdf:type schema:Person
124 N51f1f30ad308494c8ba0344e971a6635 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Male
126 rdf:type schema:DefinedTerm
127 N649f61e0cdf8482cb061b8c50b329bc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Humans
129 rdf:type schema:DefinedTerm
130 N6523ba0807c644f88b9fb0004d869b18 schema:issueNumber 1
131 rdf:type schema:PublicationIssue
132 N6a1129bb28ec4d98acf4f705ea2bca32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Female
134 rdf:type schema:DefinedTerm
135 N6c201bba4ca54a9f98568e2db987af27 rdf:first N1f6893fecb4b442bbbf06dcd0477c30a
136 rdf:rest Naf2d868fa0a941839acaab02f48af64c
137 N72243935821747c2a0b461069ee60ed3 schema:name readcube_id
138 schema:value f98228960b6675e2b1b71b5c26c6dd07b4aed302c837bf0ceb3bcdf94c15a877
139 rdf:type schema:PropertyValue
140 N76e4a5b128244d78bae5c94a63689251 schema:volumeNumber 5
141 rdf:type schema:PublicationVolume
142 N874845d553644e44995e7270d4493637 rdf:first sg:person.01100320370.44
143 rdf:rest rdf:nil
144 N8fcfae7b26494904ab2947e17f828527 schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 N9c60ea4d7b6344b794fa60791fceb73a schema:name doi
147 schema:value 10.1038/srep08096
148 rdf:type schema:PropertyValue
149 N9ef47b16f1bd4eff918d8068d3bf49b2 rdf:first N3b5a80571b26416db82914caa581ba68
150 rdf:rest N24f0e9d342944d6cb4aa99591d19e96e
151 Na194cba4262949e6854a752da06ed99f schema:name dimensions_id
152 schema:value pub.1052381018
153 rdf:type schema:PropertyValue
154 Na3fc49429cc54f54b34837de611eb351 schema:name nlm_unique_id
155 schema:value 101563288
156 rdf:type schema:PropertyValue
157 Naf2d868fa0a941839acaab02f48af64c rdf:first sg:person.01160001644.85
158 rdf:rest N1a5144a5c02b4815af3d7a4c524522d8
159 Nb3d414e98e0e4a9b925a3daacc922ebe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Interleukin-6
161 rdf:type schema:DefinedTerm
162 Nc9d5bf72683e4758974c6405463782cc rdf:first sg:person.0661211444.42
163 rdf:rest Ne6be463def184968b0db8c4608556820
164 Ncc63faf2fedc4eb5bfea3c629b823ff8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name CD4-Positive T-Lymphocytes
166 rdf:type schema:DefinedTerm
167 Nccddb53aa38a47e595a7ac999cf2f20a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Tumor Necrosis Factor-alpha
169 rdf:type schema:DefinedTerm
170 Nd5079076618249ee8b4ad9b041887c19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Cross-Sectional Studies
172 rdf:type schema:DefinedTerm
173 Nd6066359cf744f20b51aa330d68ae2c1 schema:name pubmed_id
174 schema:value 25644696
175 rdf:type schema:PropertyValue
176 Ndb3e38c8562a4869804a2c625d86cdad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Inflammation
178 rdf:type schema:DefinedTerm
179 Ndeefd99517ac439d82d553addf0d86cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Middle Aged
181 rdf:type schema:DefinedTerm
182 Ne28579113d7648baafcc05b83289897a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Interferon-gamma
184 rdf:type schema:DefinedTerm
185 Ne6be463def184968b0db8c4608556820 rdf:first sg:person.01146433570.16
186 rdf:rest N9ef47b16f1bd4eff918d8068d3bf49b2
187 Nec875895a9a24cfd951793abf67bc8f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Intestinal Mucosa
189 rdf:type schema:DefinedTerm
190 Nfa27ee86b6c94cf5b50cd57120ecb48a rdf:first sg:person.01242370164.40
191 rdf:rest N874845d553644e44995e7270d4493637
192 Nfc1cfcfb3e8b48b0bb1a3c6143a7841d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name RNA, Ribosomal, 16S
194 rdf:type schema:DefinedTerm
195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
196 schema:name Medical and Health Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
199 schema:name Clinical Sciences
200 rdf:type schema:DefinedTerm
201 sg:journal.1045337 schema:issn 2045-2322
202 schema:name Scientific Reports
203 rdf:type schema:Periodical
204 sg:person.01100320370.44 schema:affiliation https://www.grid.ac/institutes/grid.411634.5
205 schema:familyName Liu
206 schema:givenName Yulan
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100320370.44
208 rdf:type schema:Person
209 sg:person.01146433570.16 schema:affiliation https://www.grid.ac/institutes/grid.411634.5
210 schema:familyName Wu
211 schema:givenName Na
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146433570.16
213 rdf:type schema:Person
214 sg:person.01160001644.85 schema:affiliation https://www.grid.ac/institutes/grid.411634.5
215 schema:familyName Qiu
216 schema:givenName Xinyun
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160001644.85
218 rdf:type schema:Person
219 sg:person.01226115044.99 schema:affiliation https://www.grid.ac/institutes/grid.411634.5
220 schema:familyName Hu
221 schema:givenName Ying
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226115044.99
223 rdf:type schema:Person
224 sg:person.01242370164.40 schema:affiliation https://www.grid.ac/institutes/grid.411634.5
225 schema:familyName Li
226 schema:givenName Jing
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242370164.40
228 rdf:type schema:Person
229 sg:person.0661211444.42 schema:affiliation https://www.grid.ac/institutes/grid.411634.5
230 schema:familyName Jiang
231 schema:givenName Weiwei
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661211444.42
233 rdf:type schema:Person
234 sg:person.0740232777.17 schema:affiliation https://www.grid.ac/institutes/grid.411634.5
235 schema:familyName Chi
236 schema:givenName Yujing
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740232777.17
238 rdf:type schema:Person
239 sg:pub.10.1038/labinvest.2012.12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006175048
240 https://doi.org/10.1038/labinvest.2012.12
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/nature05414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023893418
243 https://doi.org/10.1038/nature05414
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/ncomms2957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003904764
246 https://doi.org/10.1038/ncomms2957
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nrgastro.2010.172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030043163
249 https://doi.org/10.1038/nrgastro.2010.172
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nrmicro1817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046322683
252 https://doi.org/10.1038/nrmicro1817
253 rdf:type schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1078352251 schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1078520589 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1082542940 schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1082736674 schema:CreativeWork
258 https://doi.org/10.1002/dmrr.2518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008370904
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1002/hep.24001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036889282
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1002/hep.26093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037397249
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1002/hep.26319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037068058
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.cgh.2012.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007062492
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.cgh.2013.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028488484
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.numecd.2012.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009877370
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.tem.2013.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019928617
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1038/oby.2008.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017880760
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1046/j.1365-2265.2001.1139/cn2155.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1056734311
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1046/j.1365-2265.2001.1139cn2155.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035818308
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1053/j.gastro.2005.11.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015555085
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1053/j.gastro.2012.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040397736
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1073/pnas.1001261107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045609563
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1073/pnas.1005963107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023427228
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1097/00075197-200409000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053556038
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1111/j.1365-3083.2011.02613.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044712949
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1126/science.1208344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015324311
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1126/science.1223490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009915545
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1136/gut.2008.165886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041802749
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1136/gutjnl-2012-303816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051857426
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1136/gutjnl-2013-304739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044827876
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1155/2010/453563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039981882
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1159/000228558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007682066
305 rdf:type schema:CreativeWork
306 https://doi.org/10.2174/1381612811319290011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069169112
307 rdf:type schema:CreativeWork
308 https://doi.org/10.4161/gmic.19625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045196658
309 rdf:type schema:CreativeWork
310 https://www.grid.ac/institutes/grid.411634.5 schema:alternateName Peking University People's Hospital
311 schema:name Department of Gastroenterology, Peking University People's Hospital, Beijing, China.
312 Institute of Clinical Molecular Biology &Central Laboratory, Peking University People's Hospital, Beijing, China.
313 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...