Noninvasive prediction of shunt operation outcome in idiopathic normal pressure hydrocephalus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-01-14

AUTHORS

Yasunori Aoki, Hiroaki Kazui, Toshihisa Tanaka, Ryouhei Ishii, Tamiki Wada, Shunichiro Ikeda, Masahiro Hata, Leonides Canuet, Themistoklis Katsimichas, Toshimitsu Musha, Haruyasu Matsuzaki, Kaoru Imajo, Hideki Kanemoto, Tetsuhiko Yoshida, Keiko Nomura, Kenji Yoshiyama, Masao Iwase, Masatoshi Takeda

ABSTRACT

Idiopathic normal pressure hydrocephalus (iNPH) is a syndrome characterized by gait disturbance, cognitive deterioration and urinary incontinence in elderly individuals. These symptoms can be improved by shunt operation in some but not all patients. Therefore, discovering predictive factors for the surgical outcome is of great clinical importance. We used normalized power variance (NPV) of electroencephalography (EEG) waves, a sensitive measure of the instability of cortical electrical activity and found significantly higher NPV in beta frequency band at the right fronto-temporo-occipital electrodes (Fp2, T4 and O2) in shunt responders compared to non-responders. By utilizing these differences, we were able to correctly identify responders and non-responders to shunt operation with a positive predictive value of 80% and a negative predictive value of 88%. Our findings indicate that NPV can be useful in noninvasively predicting the clinical outcome of shunt operation in patients with iNPH. More... »

PAGES

7775

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep07775

DOI

http://dx.doi.org/10.1038/srep07775

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011879727

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25585705


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24 schema:description Idiopathic normal pressure hydrocephalus (iNPH) is a syndrome characterized by gait disturbance, cognitive deterioration and urinary incontinence in elderly individuals. These symptoms can be improved by shunt operation in some but not all patients. Therefore, discovering predictive factors for the surgical outcome is of great clinical importance. We used normalized power variance (NPV) of electroencephalography (EEG) waves, a sensitive measure of the instability of cortical electrical activity and found significantly higher NPV in beta frequency band at the right fronto-temporo-occipital electrodes (Fp2, T4 and O2) in shunt responders compared to non-responders. By utilizing these differences, we were able to correctly identify responders and non-responders to shunt operation with a positive predictive value of 80% and a negative predictive value of 88%. Our findings indicate that NPV can be useful in noninvasively predicting the clinical outcome of shunt operation in patients with iNPH.
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