Live visualizations of single isolated tubulin protein self-assembly via tunneling current: effect of electromagnetic pumping during spontaneous growth of microtubule View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-05

AUTHORS

Satyajit Sahu, Subrata Ghosh, Daisuke Fujita, Anirban Bandyopadhyay

ABSTRACT

As we bring tubulin protein molecules one by one into the vicinity, they self-assemble and entire event we capture live via quantum tunneling. We observe how these molecules form a linear chain and then chains self-assemble into 2D sheet, an essential for microtubule, --fundamental nano-tube in a cellular life form. Even without using GTP, or any chemical reaction, but applying particular ac signal using specially designed antenna around atomic sharp tip we could carry out the self-assembly, however, if there is no electromagnetic pumping, no self-assembly is observed. In order to verify this atomic scale observation, we have built an artificial cell-like environment with nano-scale engineering and repeated spontaneous growth of tubulin protein to its complex with and without electromagnetic signal. We used 64 combinations of plant, animal and fungi tubulins and several doping molecules used as drug, and repeatedly observed that the long reported common frequency region where protein folds mechanically and its structures vibrate electromagnetically. Under pumping, the growth process exhibits a unique organized behavior unprecedented otherwise. Thus, "common frequency point" is proposed as a tool to regulate protein complex related diseases in the future. More... »

PAGES

7303

References to SciGraph publications

  • 2004-04. Microtubules as a target for anticancer drugs in NATURE REVIEWS CANCER
  • 1994-02. A model of microtubule oscillations in EUROPEAN BIOPHYSICS JOURNAL
  • 1993-05. Why microtubules grow and shrink in NATURE
  • 1999. Terahertz spectroscopy of proteins: Viscoelastic damping of boson peak oscillations in SPECTROSCOPY OF BIOLOGICAL MOLECULES: NEW DIRECTIONS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep07303

    DOI

    http://dx.doi.org/10.1038/srep07303

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006779234

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25466883


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    HOW TO GET THIS DATA PROGRAMMATICALLY:

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