Mis-splicing of the ABCC2 gene linked with Bt toxin resistance in Helicoverpa armigera View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-08-26

AUTHORS

Yutao Xiao, Tao Zhang, Chenxi Liu, David G. Heckel, Xianchun Li, Bruce E. Tabashnik, Kongming Wu

ABSTRACT

Toxins from the bacterium Bacillus thuringiensis (Bt) are used widely for insect control in sprays and transgenic plants, but their efficacy is reduced when pests evolve resistance. Previous work showed that mutations in a gene encoding the transporter protein ABCC2 are linked with resistance to Bt toxins Cry1Ab, Cry1Ac or both in four species of Lepidoptera. Here we compared the ABCC2 gene of Helicoverpa armigera (HaABCC2) between susceptible strains and a laboratory-selected strain with >1,000-fold resistance to Cry1Ac relative its susceptible parent strain. We discovered a 73-base pair (bp) insertion in the cDNA of the resistant strain that generates a premature stop codon expected to yield a truncated ABCC2 protein. Sequencing of genomic DNA revealed that this insertion is an intron that is not spliced out because of a 6-bp deletion at its splicing site. Analysis of progeny from crosses revealed tight genetic linkage between HaABCC2 and resistance to Cry1Ac. These results provide the first evidence that mis-splicing of a gene encoding an ABCC2 protein confers resistance to a Bt toxin. More... »

PAGES

6184

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep06184

DOI

http://dx.doi.org/10.1038/srep06184

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018183240

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25154974


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