DNA G-segment bending is not the sole determinant of topology simplification by type II DNA topoisomerases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-08-21

AUTHORS

Neil H. Thomson, Sergio Santos, Lesley A. Mitchenall, Tanya Stuchinskaya, James A. Taylor, Anthony Maxwell

ABSTRACT

DNA topoisomerases control the topology of DNA. Type II topoisomerases exhibit topology simplification, whereby products of their reactions are simplified beyond that expected based on thermodynamic equilibrium. The molecular basis for this process is unknown, although DNA bending has been implicated. To investigate the role of bending in topology simplification, the DNA bend angles of four enzymes of different types (IIA and IIB) were measured using atomic force microscopy (AFM). The enzymes tested were Escherichia coli topo IV and yeast topo II (type IIA enzymes that exhibit topology simplification), and Methanosarcina mazei topo VI and Sulfolobus shibatae topo VI (type IIB enzymes, which do not). Bend angles were measured using the manual tangent method from topographical AFM images taken with a novel amplitude-modulated imaging mode: small amplitude small set-point (SASS), which optimises resolution for a given AFM tip size and minimises tip convolution with the sample. This gave improved accuracy and reliability and revealed that all 4 topoisomerases bend DNA by a similar amount: ~120° between the DNA entering and exiting the enzyme complex. These data indicate that DNA bending alone is insufficient to explain topology simplification and that the 'exit gate' may be an important determinant of this process. More... »

PAGES

6158

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep06158

DOI

http://dx.doi.org/10.1038/srep06158

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009704341

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25142513


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Topoisomerases, Type II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Atomic Force", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleic Acid Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Oral Biology, School of Dentistry and Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds, LS2 9JT, United Kingdom", 
          "id": "http://www.grid.ac/institutes/grid.9909.9", 
          "name": [
            "Department of Oral Biology, School of Dentistry and Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds, LS2 9JT, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomson", 
        "givenName": "Neil H.", 
        "id": "sg:person.0710077005.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710077005.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Current address: Laboratory for Energy and NanoScience (LENS), Institute Center for Future Energy (iFES), Masdar Institute of Science and Technology, Abu Dhabi, UAE.", 
          "id": "http://www.grid.ac/institutes/grid.440568.b", 
          "name": [
            "Department of Oral Biology, School of Dentistry and Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds, LS2 9JT, United Kingdom", 
            "Current address: Laboratory for Energy and NanoScience (LENS), Institute Center for Future Energy (iFES), Masdar Institute of Science and Technology, Abu Dhabi, UAE."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santos", 
        "givenName": "Sergio", 
        "id": "sg:person.01000736713.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000736713.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Chemistry, John Innes Centre Norwich Research Park, Norwich NR4 7UH, United Kingdom", 
          "id": "http://www.grid.ac/institutes/grid.420132.6", 
          "name": [
            "Department of Biological Chemistry, John Innes Centre Norwich Research Park, Norwich NR4 7UH, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mitchenall", 
        "givenName": "Lesley A.", 
        "id": "sg:person.01035655133.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035655133.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Current address: Intelligent Fingerprinting Ltd., NRP Innovation Centre, Colney Lane, Norwich, Norfolk NR4 7GJ, United Kingdom.", 
          "id": "http://www.grid.ac/institutes/grid.420132.6", 
          "name": [
            "Department of Biological Chemistry, John Innes Centre Norwich Research Park, Norwich NR4 7UH, United Kingdom", 
            "Current address: Intelligent Fingerprinting Ltd., NRP Innovation Centre, Colney Lane, Norwich, Norfolk NR4 7GJ, United Kingdom."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stuchinskaya", 
        "givenName": "Tanya", 
        "id": "sg:person.01303461210.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303461210.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Current address: Dept. Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom.", 
          "id": "http://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "Department of Biological Chemistry, John Innes Centre Norwich Research Park, Norwich NR4 7UH, United Kingdom", 
            "Current address: Dept. Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taylor", 
        "givenName": "James A.", 
        "id": "sg:person.01344411700.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344411700.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Chemistry, John Innes Centre Norwich Research Park, Norwich NR4 7UH, United Kingdom", 
          "id": "http://www.grid.ac/institutes/grid.420132.6", 
          "name": [
            "Department of Biological Chemistry, John Innes Centre Norwich Research Park, Norwich NR4 7UH, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maxwell", 
        "givenName": "Anthony", 
        "id": "sg:person.01274446176.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274446176.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nsmb.1604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029322394", 
          "https://doi.org/10.1038/nsmb.1604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007360110", 
          "https://doi.org/10.1038/nsmb.2278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031453485", 
          "https://doi.org/10.1038/nature06396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011114592", 
          "https://doi.org/10.1038/nrm3228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00253-011-3557-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012784409", 
          "https://doi.org/10.1007/s00253-011-3557-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1892", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049111775", 
          "https://doi.org/10.1038/nsmb.1892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051423964", 
          "https://doi.org/10.1038/nsmb1264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004240050524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049309835", 
          "https://doi.org/10.1007/s004240050524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2006.63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004808294", 
          "https://doi.org/10.1038/nnano.2006.63"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/44872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014019719", 
          "https://doi.org/10.1038/44872"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-08-21", 
    "datePublishedReg": "2014-08-21", 
    "description": "DNA topoisomerases control the topology of DNA. Type II topoisomerases exhibit topology simplification, whereby products of their reactions are simplified beyond that expected based on thermodynamic equilibrium. The molecular basis for this process is unknown, although DNA bending has been implicated. To investigate the role of bending in topology simplification, the DNA bend angles of four enzymes of different types (IIA and IIB) were measured using atomic force microscopy (AFM). The enzymes tested were Escherichia coli topo IV and yeast topo II (type IIA enzymes that exhibit topology simplification), and Methanosarcina mazei topo VI and Sulfolobus shibatae topo VI (type IIB enzymes, which do not). Bend angles were measured using the manual tangent method from topographical AFM images taken with a novel amplitude-modulated imaging mode: small amplitude small set-point (SASS), which optimises resolution for a given AFM tip size and minimises tip convolution with the sample. This gave improved accuracy and reliability and revealed that all 4 topoisomerases bend DNA by a similar amount: ~120\u00b0 between the DNA entering and exiting the enzyme complex. These data indicate that DNA bending alone is insufficient to explain topology simplification and that the 'exit gate' may be an important determinant of this process. ", 
    "genre": "article", 
    "id": "sg:pub.10.1038/srep06158", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "keywords": [
      "DNA topoisomerases", 
      "type II DNA topoisomerases", 
      "atomic force microscopy", 
      "topology of DNA", 
      "DNA bend angle", 
      "bends DNA", 
      "DNA G", 
      "molecular basis", 
      "DNA bending", 
      "Methanosarcina mazei", 
      "Sulfolobus shibatae", 
      "enzyme complex", 
      "topographical AFM images", 
      "Escherichia coli", 
      "DNA", 
      "topoisomerases", 
      "force microscopy", 
      "AFM images", 
      "exit gate", 
      "enzyme", 
      "sole determinant", 
      "mazei", 
      "shibatae", 
      "yeast", 
      "thermodynamic equilibrium", 
      "bend angle", 
      "coli", 
      "similar amounts", 
      "important determinant", 
      "complexes", 
      "tip size", 
      "reaction", 
      "determinants", 
      "microscopy", 
      "role", 
      "imaging modes", 
      "topology simplification", 
      "products", 
      "process", 
      "equilibrium", 
      "basis", 
      "angle", 
      "different types", 
      "amount", 
      "types", 
      "tangent method", 
      "size", 
      "samples", 
      "tip convolution", 
      "mode", 
      "method", 
      "resolution", 
      "topology", 
      "data", 
      "bending", 
      "simplification", 
      "gate", 
      "images", 
      "accuracy", 
      "small amplitude", 
      "reliability", 
      "amplitude", 
      "convolution", 
      "Type II topoisomerases exhibit topology simplification", 
      "II topoisomerases exhibit topology simplification", 
      "topoisomerases exhibit topology simplification", 
      "exhibit topology simplification", 
      "manual tangent method", 
      "novel amplitude-modulated imaging mode", 
      "amplitude-modulated imaging mode", 
      "AFM tip size", 
      "minimises tip convolution", 
      "topoisomerases bend DNA", 
      "segment bending", 
      "II DNA topoisomerases"
    ], 
    "name": "DNA G-segment bending is not the sole determinant of topology simplification by type II DNA topoisomerases", 
    "pagination": "6158", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009704341"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep06158"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25142513"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep06158", 
      "https://app.dimensions.ai/details/publication/pub.1009704341"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_625.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/srep06158"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep06158'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep06158'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep06158'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep06158'


 

This table displays all metadata directly associated to this object as RDF triples.

248 TRIPLES      22 PREDICATES      117 URIs      99 LITERALS      13 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep06158 schema:about N3238498191d34d2f89e29667362ce920
2 N53d1ee3e2956470dafbcfb95b1d462a3
3 Ncafb291ff4744aa58dd4889b2cba8716
4 Nd613e72f250944278b8abeb5f434bd90
5 Nef5f76f885b94586bc9932a97075fa2a
6 Nf5ea7a52877b40d98f512ce2089131a4
7 anzsrc-for:06
8 anzsrc-for:0601
9 schema:author N8f1d1a2450ce4ed9950be957dfef06d4
10 schema:citation sg:pub.10.1007/s00253-011-3557-z
11 sg:pub.10.1007/s004240050524
12 sg:pub.10.1038/44872
13 sg:pub.10.1038/nature06396
14 sg:pub.10.1038/nnano.2006.63
15 sg:pub.10.1038/nrm3228
16 sg:pub.10.1038/nsmb.1604
17 sg:pub.10.1038/nsmb.1892
18 sg:pub.10.1038/nsmb.2278
19 sg:pub.10.1038/nsmb1264
20 schema:datePublished 2014-08-21
21 schema:datePublishedReg 2014-08-21
22 schema:description DNA topoisomerases control the topology of DNA. Type II topoisomerases exhibit topology simplification, whereby products of their reactions are simplified beyond that expected based on thermodynamic equilibrium. The molecular basis for this process is unknown, although DNA bending has been implicated. To investigate the role of bending in topology simplification, the DNA bend angles of four enzymes of different types (IIA and IIB) were measured using atomic force microscopy (AFM). The enzymes tested were Escherichia coli topo IV and yeast topo II (type IIA enzymes that exhibit topology simplification), and Methanosarcina mazei topo VI and Sulfolobus shibatae topo VI (type IIB enzymes, which do not). Bend angles were measured using the manual tangent method from topographical AFM images taken with a novel amplitude-modulated imaging mode: small amplitude small set-point (SASS), which optimises resolution for a given AFM tip size and minimises tip convolution with the sample. This gave improved accuracy and reliability and revealed that all 4 topoisomerases bend DNA by a similar amount: ~120° between the DNA entering and exiting the enzyme complex. These data indicate that DNA bending alone is insufficient to explain topology simplification and that the 'exit gate' may be an important determinant of this process.
23 schema:genre article
24 schema:inLanguage en
25 schema:isAccessibleForFree true
26 schema:isPartOf Nae0ab38a735f47ffa728ab5716b23007
27 Ndea12f44097d40f2ac35098f4858bd6f
28 sg:journal.1045337
29 schema:keywords AFM images
30 AFM tip size
31 DNA
32 DNA G
33 DNA bend angle
34 DNA bending
35 DNA topoisomerases
36 Escherichia coli
37 II DNA topoisomerases
38 II topoisomerases exhibit topology simplification
39 Methanosarcina mazei
40 Sulfolobus shibatae
41 Type II topoisomerases exhibit topology simplification
42 accuracy
43 amount
44 amplitude
45 amplitude-modulated imaging mode
46 angle
47 atomic force microscopy
48 basis
49 bend angle
50 bending
51 bends DNA
52 coli
53 complexes
54 convolution
55 data
56 determinants
57 different types
58 enzyme
59 enzyme complex
60 equilibrium
61 exhibit topology simplification
62 exit gate
63 force microscopy
64 gate
65 images
66 imaging modes
67 important determinant
68 manual tangent method
69 mazei
70 method
71 microscopy
72 minimises tip convolution
73 mode
74 molecular basis
75 novel amplitude-modulated imaging mode
76 process
77 products
78 reaction
79 reliability
80 resolution
81 role
82 samples
83 segment bending
84 shibatae
85 similar amounts
86 simplification
87 size
88 small amplitude
89 sole determinant
90 tangent method
91 thermodynamic equilibrium
92 tip convolution
93 tip size
94 topographical AFM images
95 topoisomerases
96 topoisomerases bend DNA
97 topoisomerases exhibit topology simplification
98 topology
99 topology of DNA
100 topology simplification
101 type II DNA topoisomerases
102 types
103 yeast
104 schema:name DNA G-segment bending is not the sole determinant of topology simplification by type II DNA topoisomerases
105 schema:pagination 6158
106 schema:productId N0597bd3fa14b4943be338a21dba4d516
107 N0c74bca91ea84addb4c423770a079988
108 N1d9ad7790d154bae8dbf1fcd0c1d846b
109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009704341
110 https://doi.org/10.1038/srep06158
111 schema:sdDatePublished 2021-11-01T18:22
112 schema:sdLicense https://scigraph.springernature.com/explorer/license/
113 schema:sdPublisher Nbffd9ae066fa4d8199a7744dec872d51
114 schema:url https://doi.org/10.1038/srep06158
115 sgo:license sg:explorer/license/
116 sgo:sdDataset articles
117 rdf:type schema:ScholarlyArticle
118 N0597bd3fa14b4943be338a21dba4d516 schema:name dimensions_id
119 schema:value pub.1009704341
120 rdf:type schema:PropertyValue
121 N0c74bca91ea84addb4c423770a079988 schema:name doi
122 schema:value 10.1038/srep06158
123 rdf:type schema:PropertyValue
124 N1d9ad7790d154bae8dbf1fcd0c1d846b schema:name pubmed_id
125 schema:value 25142513
126 rdf:type schema:PropertyValue
127 N27c7cab7ce124a86a0ca13b174023a36 rdf:first sg:person.01000736713.86
128 rdf:rest N33399447924f4075a1736a37ef2e3d85
129 N3238498191d34d2f89e29667362ce920 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name DNA
131 rdf:type schema:DefinedTerm
132 N33399447924f4075a1736a37ef2e3d85 rdf:first sg:person.01035655133.87
133 rdf:rest N371cf56ee7ba4bfd8e6628a822fda904
134 N371cf56ee7ba4bfd8e6628a822fda904 rdf:first sg:person.01303461210.16
135 rdf:rest Nf57a0ad2e15449d8b63382daf3c33fa1
136 N53d1ee3e2956470dafbcfb95b1d462a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Microscopy, Atomic Force
138 rdf:type schema:DefinedTerm
139 N8f1d1a2450ce4ed9950be957dfef06d4 rdf:first sg:person.0710077005.07
140 rdf:rest N27c7cab7ce124a86a0ca13b174023a36
141 N90e40c3989da4db790fe0afcf5a151da rdf:first sg:person.01274446176.29
142 rdf:rest rdf:nil
143 Nae0ab38a735f47ffa728ab5716b23007 schema:issueNumber 1
144 rdf:type schema:PublicationIssue
145 Nbffd9ae066fa4d8199a7744dec872d51 schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 Ncafb291ff4744aa58dd4889b2cba8716 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Protein Binding
149 rdf:type schema:DefinedTerm
150 Nd613e72f250944278b8abeb5f434bd90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Molecular Weight
152 rdf:type schema:DefinedTerm
153 Ndea12f44097d40f2ac35098f4858bd6f schema:volumeNumber 4
154 rdf:type schema:PublicationVolume
155 Nef5f76f885b94586bc9932a97075fa2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name DNA Topoisomerases, Type II
157 rdf:type schema:DefinedTerm
158 Nf57a0ad2e15449d8b63382daf3c33fa1 rdf:first sg:person.01344411700.38
159 rdf:rest N90e40c3989da4db790fe0afcf5a151da
160 Nf5ea7a52877b40d98f512ce2089131a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Nucleic Acid Conformation
162 rdf:type schema:DefinedTerm
163 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
164 schema:name Biological Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
167 schema:name Biochemistry and Cell Biology
168 rdf:type schema:DefinedTerm
169 sg:journal.1045337 schema:issn 2045-2322
170 schema:name Scientific Reports
171 schema:publisher Springer Nature
172 rdf:type schema:Periodical
173 sg:person.01000736713.86 schema:affiliation grid-institutes:grid.440568.b
174 schema:familyName Santos
175 schema:givenName Sergio
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000736713.86
177 rdf:type schema:Person
178 sg:person.01035655133.87 schema:affiliation grid-institutes:grid.420132.6
179 schema:familyName Mitchenall
180 schema:givenName Lesley A.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035655133.87
182 rdf:type schema:Person
183 sg:person.01274446176.29 schema:affiliation grid-institutes:grid.420132.6
184 schema:familyName Maxwell
185 schema:givenName Anthony
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274446176.29
187 rdf:type schema:Person
188 sg:person.01303461210.16 schema:affiliation grid-institutes:grid.420132.6
189 schema:familyName Stuchinskaya
190 schema:givenName Tanya
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303461210.16
192 rdf:type schema:Person
193 sg:person.01344411700.38 schema:affiliation grid-institutes:grid.5337.2
194 schema:familyName Taylor
195 schema:givenName James A.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344411700.38
197 rdf:type schema:Person
198 sg:person.0710077005.07 schema:affiliation grid-institutes:grid.9909.9
199 schema:familyName Thomson
200 schema:givenName Neil H.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710077005.07
202 rdf:type schema:Person
203 sg:pub.10.1007/s00253-011-3557-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1012784409
204 https://doi.org/10.1007/s00253-011-3557-z
205 rdf:type schema:CreativeWork
206 sg:pub.10.1007/s004240050524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049309835
207 https://doi.org/10.1007/s004240050524
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/44872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014019719
210 https://doi.org/10.1038/44872
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/nature06396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031453485
213 https://doi.org/10.1038/nature06396
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/nnano.2006.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004808294
216 https://doi.org/10.1038/nnano.2006.63
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/nrm3228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011114592
219 https://doi.org/10.1038/nrm3228
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/nsmb.1604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029322394
222 https://doi.org/10.1038/nsmb.1604
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/nsmb.1892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049111775
225 https://doi.org/10.1038/nsmb.1892
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/nsmb.2278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007360110
228 https://doi.org/10.1038/nsmb.2278
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/nsmb1264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051423964
231 https://doi.org/10.1038/nsmb1264
232 rdf:type schema:CreativeWork
233 grid-institutes:grid.420132.6 schema:alternateName Current address: Intelligent Fingerprinting Ltd., NRP Innovation Centre, Colney Lane, Norwich, Norfolk NR4 7GJ, United Kingdom.
234 Department of Biological Chemistry, John Innes Centre Norwich Research Park, Norwich NR4 7UH, United Kingdom
235 schema:name Current address: Intelligent Fingerprinting Ltd., NRP Innovation Centre, Colney Lane, Norwich, Norfolk NR4 7GJ, United Kingdom.
236 Department of Biological Chemistry, John Innes Centre Norwich Research Park, Norwich NR4 7UH, United Kingdom
237 rdf:type schema:Organization
238 grid-institutes:grid.440568.b schema:alternateName Current address: Laboratory for Energy and NanoScience (LENS), Institute Center for Future Energy (iFES), Masdar Institute of Science and Technology, Abu Dhabi, UAE.
239 schema:name Current address: Laboratory for Energy and NanoScience (LENS), Institute Center for Future Energy (iFES), Masdar Institute of Science and Technology, Abu Dhabi, UAE.
240 Department of Oral Biology, School of Dentistry and Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds, LS2 9JT, United Kingdom
241 rdf:type schema:Organization
242 grid-institutes:grid.5337.2 schema:alternateName Current address: Dept. Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom.
243 schema:name Current address: Dept. Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom.
244 Department of Biological Chemistry, John Innes Centre Norwich Research Park, Norwich NR4 7UH, United Kingdom
245 rdf:type schema:Organization
246 grid-institutes:grid.9909.9 schema:alternateName Department of Oral Biology, School of Dentistry and Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds, LS2 9JT, United Kingdom
247 schema:name Department of Oral Biology, School of Dentistry and Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds, LS2 9JT, United Kingdom
248 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...