Binding of fullerenes and nanotubes to MscL View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-05

AUTHORS

Tamsyn A Hilder, Pietro Ridone, Yoshitaka Nakayama, Boris Martinac, Shin-Ho Chung

ABSTRACT

Multi-drug resistance is becoming an increasing problem in the treatment of bacterial infections and diseases. The mechanosensitive channel of large conductance (MscL) is highly conserved among prokaryotes. Evidence suggests that a pharmacological agent that can affect the gating of, or block the current through, MscL has significant potential as a new class of antimicrobial compound capable of targeting a range of pathogenic bacteria with minimal side-effects to infected patients. Using molecular dynamics we examine the binding of fullerenes and nanotubes to MscL and demonstrate that both are stable within the MscL pore. We predict that fullerenes will attenuate the flow of ions through MscL by reducing the pore volume available to water and ions, but nanotubes will prevent pore closure resulting in a permanently open pore. Moreover, we confirm experimentally that it is possible to attenuate the flow of ions through MscL using a C60-γ cyclodextrin complex. More... »

PAGES

5609

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep05609

DOI

http://dx.doi.org/10.1038/srep05609

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020083642

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25030051


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