Disruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-05

AUTHORS

Silke Fuchs, Ermelinda Rende, Andrea Crisanti, Tony Nolan

ABSTRACT

Insecticide resistance amongst disease vectors is a growing problem and novel compounds are needed. Biogenic amines are important for neurotransmission and we have recently shown a potential role for these in mosquito fertility. Here, we dissected the relative contribution of different aminergic signalling pathways to biological processes essential for vectorial capacity such as fertility, locomotion and survival by injecting agonists and antagonists and showed that octopaminergic/tyraminergic signalling is essential for oviposition and hatching rate. We show that egg melanisation is regulated by adrenergic signalling, whose disruption causes premature melanisation specifically through the action of tyramine. In addition to this, co-injection of tyramine with DOPA, the precursor of melanin, had a strong cumulative negative effect on mosquito locomotion and survival. Dopaminergic and serotonergic antagonists such as amitriptyline and citalopram recapitulate this effect. Together these results reveal potential new target sites for the development of future mosquito sterilants and insecticides. More... »

PAGES

5526

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep05526

DOI

http://dx.doi.org/10.1038/srep05526

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040482703

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24984706


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anopheles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biogenic Amines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insecticides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Locomotion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sexual Behavior, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Department of Life Sciences, Imperial College London, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fuchs", 
        "givenName": "Silke", 
        "id": "sg:person.01276212752.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276212752.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Calabria", 
          "id": "https://www.grid.ac/institutes/grid.7778.f", 
          "name": [
            "Department of Pharmaco-Biology, Faculty of Pharmacy, University of Calabria, Arcavacata di Rende, Cosenza, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rende", 
        "givenName": "Ermelinda", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Department of Life Sciences, Imperial College London, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crisanti", 
        "givenName": "Andrea", 
        "id": "sg:person.01034617712.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034617712.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Department of Life Sciences, Imperial College London, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nolan", 
        "givenName": "Tony", 
        "id": "sg:person.01034434475.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034434475.71"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/jnc.12158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001972070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinsphys.2009.11.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005489902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ps.2780110616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005499328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2009.02.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007029626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinsphys.2006.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007717508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2005.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008433710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2005.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008433710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2806(08)60143-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008961662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4612-4832-3_6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009521342", 
          "https://doi.org/10.1007/978-1-4612-4832-3_6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01929916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010306020", 
          "https://doi.org/10.1007/bf01929916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01929916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010306020", 
          "https://doi.org/10.1007/bf01929916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0924-980x(96)96532-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011646981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0924-980x(96)96532-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011646981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1998.70010015.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011726142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/neu.480160303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012737525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(95)00224-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012851497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dneu.20355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013192306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(97)00723-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014826975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00005357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014950906", 
          "https://doi.org/10.1007/pl00005357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-6147(00)01678-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015899364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2007.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016434731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/arch.1055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016437422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.10.058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017402093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.10.058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017402093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2048-05.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017757199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0007485300034350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018274738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0007485300034350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018274738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0007485300034350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018274738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(85)90467-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018520825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(85)90467-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018520825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci110208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019206331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03189516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020118527", 
          "https://doi.org/10.1007/bf03189516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03189516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020118527", 
          "https://doi.org/10.1007/bf03189516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jnc.12526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020303540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0001478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020857243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.20722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021101388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2660(08)60008-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021173374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.202498299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021204364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0742-8413(92)90111-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022307366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0742-8413(92)90111-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022307366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ento.50.071803.130404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023003272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2003.07.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025481714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkh340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025846396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chembiol.2009.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026178260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1139/z82-095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026528536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10158-005-0001-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027619675", 
          "https://doi.org/10.1007/s10158-005-0001-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10158-005-0001-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027619675", 
          "https://doi.org/10.1007/s10158-005-0001-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2009.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028613371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0084865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029269200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2004.02835.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029293184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2004.02835.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029293184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(97)01393-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029416754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(89)90238-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030757293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00572434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031719143", 
          "https://doi.org/10.1007/bf00572434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.01389.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031925029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2003.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032187964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0965-1748(93)90048-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033958713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0965-1748(93)90048-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033958713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2396(200002)35:2<79::aid-syn1>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035188286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ddr.430030407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035615759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1981.sp013853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037363331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0027073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037412038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02244985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037692228", 
          "https://doi.org/10.1007/bf02244985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02244985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037692228", 
          "https://doi.org/10.1007/bf02244985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2567.2007.02722.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038109824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1076196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038932727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2009.05.066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039977223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/neu.480170502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041479836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/neu.480170502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041479836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/neu.10298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046993277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.12.5441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047176618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(94)91530-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047209010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(94)91530-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047209010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.3.808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049253976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0305-0491(98)10160-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049314239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinsphys.2012.01.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049598645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygcen.2008.10.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051062167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(77)90066-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051179459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(77)90066-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051179459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3959(01)00464-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051846576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3959(01)00464-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051846576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/lm.028167.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052753348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(78)90148-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052885439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(78)90148-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052885439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2704-07.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053067300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.50.6_suppl_6.s11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064376396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.50.6_suppl_6.s11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064376396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.50.6_suppl_6.s11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064376396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1603/0022-2585-37.6.878", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068118196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/156802608785161457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069193712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2460/javma.2001.219.185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070766612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2460/javma.2001.219.185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070766612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074464161", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1992.tb05021.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075464968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076078545", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077246714", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077372923", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1990.tb07572.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078415062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079447562", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080157235", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081573427", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1994.tb06385.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082668469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082728647", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082746507", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.16-12-03900.1996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082896571"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-05", 
    "datePublishedReg": "2015-05-01", 
    "description": "Insecticide resistance amongst disease vectors is a growing problem and novel compounds are needed. Biogenic amines are important for neurotransmission and we have recently shown a potential role for these in mosquito fertility. Here, we dissected the relative contribution of different aminergic signalling pathways to biological processes essential for vectorial capacity such as fertility, locomotion and survival by injecting agonists and antagonists and showed that octopaminergic/tyraminergic signalling is essential for oviposition and hatching rate. We show that egg melanisation is regulated by adrenergic signalling, whose disruption causes premature melanisation specifically through the action of tyramine. In addition to this, co-injection of tyramine with DOPA, the precursor of melanin, had a strong cumulative negative effect on mosquito locomotion and survival. Dopaminergic and serotonergic antagonists such as amitriptyline and citalopram recapitulate this effect. Together these results reveal potential new target sites for the development of future mosquito sterilants and insecticides. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep05526", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3777010", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3778011", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Disruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival", 
    "pagination": "5526", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c0d7eb6dba408db573829990111cf09901157018003785c4e040e75fd35a27eb"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24984706"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep05526"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040482703"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep05526", 
      "https://app.dimensions.ai/details/publication/pub.1040482703"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000551.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2014/140702/srep05526/full/srep05526.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep05526'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep05526'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep05526'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep05526'


 

This table displays all metadata directly associated to this object as RDF triples.

385 TRIPLES      21 PREDICATES      123 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep05526 schema:about N34b549a4f72e4a45aac13a3c86670ca3
2 N53967bc421a3466c88475dcbedc9d775
3 N7d523b54b6d64d46845407eb68e547ad
4 N7faa648db79847eca11dc6f8057835e5
5 Nc1b610e7411348e6af419b6c6abe9bb9
6 Nc5f0f37e3f484330ade7210850fefcfa
7 Nc63d157b05964fff88a30012da44c030
8 Ncee5058d5e25411f81df67982f7196e1
9 Ne55a27eaf3f945ea81689a9a35c71807
10 Ne73f022a87c04f0cb67a6fe5f5ff098e
11 anzsrc-for:06
12 anzsrc-for:0601
13 schema:author N5c9250e5108e40c8b2c4221dea23487b
14 schema:citation sg:pub.10.1007/978-1-4612-4832-3_6
15 sg:pub.10.1007/bf00572434
16 sg:pub.10.1007/bf01929916
17 sg:pub.10.1007/bf02244985
18 sg:pub.10.1007/bf03189516
19 sg:pub.10.1007/pl00005357
20 sg:pub.10.1007/s10158-005-0001-z
21 https://app.dimensions.ai/details/publication/pub.1074464161
22 https://app.dimensions.ai/details/publication/pub.1076078545
23 https://app.dimensions.ai/details/publication/pub.1077246714
24 https://app.dimensions.ai/details/publication/pub.1077372923
25 https://app.dimensions.ai/details/publication/pub.1079447562
26 https://app.dimensions.ai/details/publication/pub.1080157235
27 https://app.dimensions.ai/details/publication/pub.1081573427
28 https://app.dimensions.ai/details/publication/pub.1082728647
29 https://app.dimensions.ai/details/publication/pub.1082746507
30 https://doi.org/10.1002/(sici)1098-2396(200002)35:2<79::aid-syn1>3.0.co;2-x
31 https://doi.org/10.1002/arch.1055
32 https://doi.org/10.1002/ddr.430030407
33 https://doi.org/10.1002/dneu.20355
34 https://doi.org/10.1002/j.1460-2075.1990.tb07572.x
35 https://doi.org/10.1002/j.1460-2075.1992.tb05021.x
36 https://doi.org/10.1002/j.1460-2075.1994.tb06385.x
37 https://doi.org/10.1002/jcp.20722
38 https://doi.org/10.1002/neu.10298
39 https://doi.org/10.1002/neu.480160303
40 https://doi.org/10.1002/neu.480170502
41 https://doi.org/10.1002/ps.2780110616
42 https://doi.org/10.1016/0006-8993(94)91530-x
43 https://doi.org/10.1016/0014-2999(78)90148-6
44 https://doi.org/10.1016/0014-2999(85)90467-4
45 https://doi.org/10.1016/0014-2999(89)90238-0
46 https://doi.org/10.1016/0014-5793(95)00224-w
47 https://doi.org/10.1016/0024-3205(77)90066-2
48 https://doi.org/10.1016/0742-8413(92)90111-j
49 https://doi.org/10.1016/0924-980x(96)96532-7
50 https://doi.org/10.1016/0965-1748(93)90048-w
51 https://doi.org/10.1016/j.actatropica.2007.01.005
52 https://doi.org/10.1016/j.bbrc.2005.10.058
53 https://doi.org/10.1016/j.biopsych.2003.07.006
54 https://doi.org/10.1016/j.biopsych.2005.07.011
55 https://doi.org/10.1016/j.chembiol.2009.05.010
56 https://doi.org/10.1016/j.jinsphys.2006.07.008
57 https://doi.org/10.1016/j.jinsphys.2009.11.018
58 https://doi.org/10.1016/j.jinsphys.2012.01.006
59 https://doi.org/10.1016/j.neuron.2009.04.013
60 https://doi.org/10.1016/j.neuroscience.2009.05.066
61 https://doi.org/10.1016/j.ydbio.2003.07.019
62 https://doi.org/10.1016/j.ydbio.2009.02.038
63 https://doi.org/10.1016/j.ygcen.2008.10.013
64 https://doi.org/10.1016/s0006-8993(97)00723-3
65 https://doi.org/10.1016/s0014-2999(97)01393-9
66 https://doi.org/10.1016/s0065-2660(08)60008-5
67 https://doi.org/10.1016/s0065-2806(08)60143-5
68 https://doi.org/10.1016/s0165-6147(00)01678-3
69 https://doi.org/10.1016/s0304-3959(01)00464-x
70 https://doi.org/10.1016/s0305-0491(98)10160-8
71 https://doi.org/10.1017/s0007485300034350
72 https://doi.org/10.1046/j.1471-4159.1998.70010015.x
73 https://doi.org/10.1073/pnas.202498299
74 https://doi.org/10.1073/pnas.92.12.5441
75 https://doi.org/10.1073/pnas.94.3.808
76 https://doi.org/10.1093/nar/gkh340
77 https://doi.org/10.1101/lm.028167.112
78 https://doi.org/10.1111/j.1365-2567.2007.02722.x
79 https://doi.org/10.1111/j.1471-4159.2004.02835.x
80 https://doi.org/10.1111/jnc.12158
81 https://doi.org/10.1111/jnc.12526
82 https://doi.org/10.1113/jphysiol.1981.sp013853
83 https://doi.org/10.1126/science.1076196
84 https://doi.org/10.1139/z82-095
85 https://doi.org/10.1146/annurev.ento.50.071803.130404
86 https://doi.org/10.1152/ajpheart.01389.2006
87 https://doi.org/10.1172/jci110208
88 https://doi.org/10.1212/wnl.50.6_suppl_6.s11
89 https://doi.org/10.1371/journal.pntd.0001478
90 https://doi.org/10.1371/journal.pone.0027073
91 https://doi.org/10.1371/journal.pone.0084865
92 https://doi.org/10.1523/jneurosci.16-12-03900.1996
93 https://doi.org/10.1523/jneurosci.2048-05.2005
94 https://doi.org/10.1523/jneurosci.2704-07.2007
95 https://doi.org/10.1603/0022-2585-37.6.878
96 https://doi.org/10.2174/156802608785161457
97 https://doi.org/10.2460/javma.2001.219.185
98 schema:datePublished 2015-05
99 schema:datePublishedReg 2015-05-01
100 schema:description Insecticide resistance amongst disease vectors is a growing problem and novel compounds are needed. Biogenic amines are important for neurotransmission and we have recently shown a potential role for these in mosquito fertility. Here, we dissected the relative contribution of different aminergic signalling pathways to biological processes essential for vectorial capacity such as fertility, locomotion and survival by injecting agonists and antagonists and showed that octopaminergic/tyraminergic signalling is essential for oviposition and hatching rate. We show that egg melanisation is regulated by adrenergic signalling, whose disruption causes premature melanisation specifically through the action of tyramine. In addition to this, co-injection of tyramine with DOPA, the precursor of melanin, had a strong cumulative negative effect on mosquito locomotion and survival. Dopaminergic and serotonergic antagonists such as amitriptyline and citalopram recapitulate this effect. Together these results reveal potential new target sites for the development of future mosquito sterilants and insecticides.
101 schema:genre research_article
102 schema:inLanguage en
103 schema:isAccessibleForFree true
104 schema:isPartOf N5ee7030d8f7b405a9323d32387e24795
105 Ndd8f37e870af4561828103d70d868387
106 sg:journal.1045337
107 schema:name Disruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival
108 schema:pagination 5526
109 schema:productId N60d93bf9050741f5bd7a1bd1c146614c
110 N736cdb6c05e94ee99a1c6e246376e8d8
111 Nb72dfe7380d74571b6a8760e6282810b
112 Neaf081c77f07467db0db6e2f2596834c
113 Nebd3d0edd2944e1b8f60c18fd8a2069d
114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040482703
115 https://doi.org/10.1038/srep05526
116 schema:sdDatePublished 2019-04-10T20:53
117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
118 schema:sdPublisher N5d70d0dafdb14dd7abf76d69364f4467
119 schema:url http://www.nature.com/srep/2014/140702/srep05526/full/srep05526.html
120 sgo:license sg:explorer/license/
121 sgo:sdDataset articles
122 rdf:type schema:ScholarlyArticle
123 N2b2fbf6f083443a0b2b157819ad658a4 schema:affiliation https://www.grid.ac/institutes/grid.7778.f
124 schema:familyName Rende
125 schema:givenName Ermelinda
126 rdf:type schema:Person
127 N34b549a4f72e4a45aac13a3c86670ca3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Dose-Response Relationship, Drug
129 rdf:type schema:DefinedTerm
130 N53967bc421a3466c88475dcbedc9d775 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Biogenic Amines
132 rdf:type schema:DefinedTerm
133 N5c9250e5108e40c8b2c4221dea23487b rdf:first sg:person.01276212752.53
134 rdf:rest N80a469060d0f43148caec198c8c7b1f1
135 N5d70d0dafdb14dd7abf76d69364f4467 schema:name Springer Nature - SN SciGraph project
136 rdf:type schema:Organization
137 N5ee7030d8f7b405a9323d32387e24795 schema:volumeNumber 4
138 rdf:type schema:PublicationVolume
139 N60d93bf9050741f5bd7a1bd1c146614c schema:name dimensions_id
140 schema:value pub.1040482703
141 rdf:type schema:PropertyValue
142 N6cdc7e63dcd840fea79b963ce0c47092 rdf:first sg:person.01034434475.71
143 rdf:rest rdf:nil
144 N71122ae04a9d47d6afad3bb50b75c10f rdf:first sg:person.01034617712.80
145 rdf:rest N6cdc7e63dcd840fea79b963ce0c47092
146 N736cdb6c05e94ee99a1c6e246376e8d8 schema:name pubmed_id
147 schema:value 24984706
148 rdf:type schema:PropertyValue
149 N7d523b54b6d64d46845407eb68e547ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Insecticides
151 rdf:type schema:DefinedTerm
152 N7faa648db79847eca11dc6f8057835e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Anopheles
154 rdf:type schema:DefinedTerm
155 N80a469060d0f43148caec198c8c7b1f1 rdf:first N2b2fbf6f083443a0b2b157819ad658a4
156 rdf:rest N71122ae04a9d47d6afad3bb50b75c10f
157 Nb72dfe7380d74571b6a8760e6282810b schema:name nlm_unique_id
158 schema:value 101563288
159 rdf:type schema:PropertyValue
160 Nc1b610e7411348e6af419b6c6abe9bb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Survival Rate
162 rdf:type schema:DefinedTerm
163 Nc5f0f37e3f484330ade7210850fefcfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Treatment Outcome
165 rdf:type schema:DefinedTerm
166 Nc63d157b05964fff88a30012da44c030 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Reproduction
168 rdf:type schema:DefinedTerm
169 Ncee5058d5e25411f81df67982f7196e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Sexual Behavior, Animal
171 rdf:type schema:DefinedTerm
172 Ndd8f37e870af4561828103d70d868387 schema:issueNumber 1
173 rdf:type schema:PublicationIssue
174 Ne55a27eaf3f945ea81689a9a35c71807 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Animals
176 rdf:type schema:DefinedTerm
177 Ne73f022a87c04f0cb67a6fe5f5ff098e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Locomotion
179 rdf:type schema:DefinedTerm
180 Neaf081c77f07467db0db6e2f2596834c schema:name doi
181 schema:value 10.1038/srep05526
182 rdf:type schema:PropertyValue
183 Nebd3d0edd2944e1b8f60c18fd8a2069d schema:name readcube_id
184 schema:value c0d7eb6dba408db573829990111cf09901157018003785c4e040e75fd35a27eb
185 rdf:type schema:PropertyValue
186 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
187 schema:name Biological Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
190 schema:name Biochemistry and Cell Biology
191 rdf:type schema:DefinedTerm
192 sg:grant.3777010 http://pending.schema.org/fundedItem sg:pub.10.1038/srep05526
193 rdf:type schema:MonetaryGrant
194 sg:grant.3778011 http://pending.schema.org/fundedItem sg:pub.10.1038/srep05526
195 rdf:type schema:MonetaryGrant
196 sg:journal.1045337 schema:issn 2045-2322
197 schema:name Scientific Reports
198 rdf:type schema:Periodical
199 sg:person.01034434475.71 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
200 schema:familyName Nolan
201 schema:givenName Tony
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034434475.71
203 rdf:type schema:Person
204 sg:person.01034617712.80 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
205 schema:familyName Crisanti
206 schema:givenName Andrea
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034617712.80
208 rdf:type schema:Person
209 sg:person.01276212752.53 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
210 schema:familyName Fuchs
211 schema:givenName Silke
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276212752.53
213 rdf:type schema:Person
214 sg:pub.10.1007/978-1-4612-4832-3_6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009521342
215 https://doi.org/10.1007/978-1-4612-4832-3_6
216 rdf:type schema:CreativeWork
217 sg:pub.10.1007/bf00572434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031719143
218 https://doi.org/10.1007/bf00572434
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/bf01929916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010306020
221 https://doi.org/10.1007/bf01929916
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/bf02244985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037692228
224 https://doi.org/10.1007/bf02244985
225 rdf:type schema:CreativeWork
226 sg:pub.10.1007/bf03189516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020118527
227 https://doi.org/10.1007/bf03189516
228 rdf:type schema:CreativeWork
229 sg:pub.10.1007/pl00005357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014950906
230 https://doi.org/10.1007/pl00005357
231 rdf:type schema:CreativeWork
232 sg:pub.10.1007/s10158-005-0001-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1027619675
233 https://doi.org/10.1007/s10158-005-0001-z
234 rdf:type schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1074464161 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1076078545 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1077246714 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1077372923 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1079447562 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1080157235 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1081573427 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1082728647 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1082746507 schema:CreativeWork
244 https://doi.org/10.1002/(sici)1098-2396(200002)35:2<79::aid-syn1>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035188286
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/arch.1055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016437422
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1002/ddr.430030407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035615759
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1002/dneu.20355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013192306
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1002/j.1460-2075.1990.tb07572.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1078415062
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1002/j.1460-2075.1992.tb05021.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1075464968
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1002/j.1460-2075.1994.tb06385.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082668469
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1002/jcp.20722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021101388
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1002/neu.10298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046993277
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1002/neu.480160303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012737525
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1002/neu.480170502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041479836
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1002/ps.2780110616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005499328
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/0006-8993(94)91530-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047209010
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/0014-2999(78)90148-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052885439
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/0014-2999(85)90467-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018520825
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/0014-2999(89)90238-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030757293
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/0014-5793(95)00224-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1012851497
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/0024-3205(77)90066-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051179459
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/0742-8413(92)90111-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1022307366
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/0924-980x(96)96532-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011646981
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/0965-1748(93)90048-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1033958713
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.actatropica.2007.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016434731
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.bbrc.2005.10.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017402093
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.biopsych.2003.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032187964
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.biopsych.2005.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008433710
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.chembiol.2009.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026178260
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.jinsphys.2006.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007717508
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.jinsphys.2009.11.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005489902
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.jinsphys.2012.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049598645
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.neuron.2009.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028613371
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.neuroscience.2009.05.066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039977223
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.ydbio.2003.07.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025481714
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.ydbio.2009.02.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007029626
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.ygcen.2008.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051062167
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/s0006-8993(97)00723-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014826975
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/s0014-2999(97)01393-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029416754
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/s0065-2660(08)60008-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021173374
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/s0065-2806(08)60143-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008961662
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/s0165-6147(00)01678-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015899364
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/s0304-3959(01)00464-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051846576
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/s0305-0491(98)10160-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049314239
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1017/s0007485300034350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018274738
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1046/j.1471-4159.1998.70010015.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011726142
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1073/pnas.202498299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021204364
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1073/pnas.92.12.5441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047176618
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1073/pnas.94.3.808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049253976
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/nar/gkh340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025846396
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1101/lm.028167.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052753348
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1111/j.1365-2567.2007.02722.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038109824
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1111/j.1471-4159.2004.02835.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029293184
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1111/jnc.12158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001972070
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1111/jnc.12526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020303540
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1113/jphysiol.1981.sp013853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037363331
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1126/science.1076196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038932727
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1139/z82-095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026528536
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1146/annurev.ento.50.071803.130404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023003272
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1152/ajpheart.01389.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031925029
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1172/jci110208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019206331
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1212/wnl.50.6_suppl_6.s11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064376396
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1371/journal.pntd.0001478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020857243
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1371/journal.pone.0027073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037412038
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1371/journal.pone.0084865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029269200
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1523/jneurosci.16-12-03900.1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082896571
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1523/jneurosci.2048-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017757199
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1523/jneurosci.2704-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053067300
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1603/0022-2585-37.6.878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068118196
375 rdf:type schema:CreativeWork
376 https://doi.org/10.2174/156802608785161457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069193712
377 rdf:type schema:CreativeWork
378 https://doi.org/10.2460/javma.2001.219.185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070766612
379 rdf:type schema:CreativeWork
380 https://www.grid.ac/institutes/grid.7445.2 schema:alternateName Imperial College London
381 schema:name Department of Life Sciences, Imperial College London, London, UK.
382 rdf:type schema:Organization
383 https://www.grid.ac/institutes/grid.7778.f schema:alternateName University of Calabria
384 schema:name Department of Pharmaco-Biology, Faculty of Pharmacy, University of Calabria, Arcavacata di Rende, Cosenza, Italy.
385 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...