Cisplatin modulates B-cell translocation gene 2 to attenuate cell proliferation of prostate carcinoma cells in both p53-dependent and p53-independent pathways View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-05

AUTHORS

Kun-Chun Chiang, Ke-Hung Tsui, Li-Chuan Chung, Chun-Nan Yeh, Tsui-Hsia Feng, Wen-Tsung Chen, Phei-Lang Chang, Hou-Yu Chiang, Horng-Heng Juang

ABSTRACT

Cisplatin is a widely used anti-cancer drug. The B-cell translocation gene 2 (BTG2) is involved in the cell cycle transition regulation. We evaluated the cisplatin effects on prostate cancer cell proliferation and the expressions of BTG2, p53, androgen receptor (AR) and prostate specific antigen (PSA) in prostate carcinoma, p53 wild-type LNCaP or p53-null PC-3, cells. Cisplatin treatments attenuated cell prostate cancer cell growth through inducing Go/G1 cell cycle arrest in lower concentration and apoptosis at higher dosage. Cisplatin treatments enhanced p53 and BTG2 expression, repressed AR and PSA expression, and blocked the activation of androgen on the PSA secretion in LNCaP cells. BTG2 knockdown in LNCaP cells attenuated cisplatin-mediated growth inhibition. Cisplatin enhanced BTG2 gene expression dependent on the DNA fragment located within -173 to -82 upstream of BTG2 translation initiation site in prostate cancer cells. Mutation of the p53 response element from GGGCAGAGCCC to GGGCACC or mutation of the NFκB response element from GGAAAGTCC to GGAAAGGAA by site-directed mutagenesis abolished the stimulation of cisplatin on the BTG2 promoter activity in LNCaP or PC-3 cells, respectively. Our results indicated that cisplatin attenuates prostate cancer cell proliferation partly mediated by upregulation of BTG2 through the p53-dependent pathway or p53-independent NFκB pathway. More... »

PAGES

5511

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep05511

DOI

http://dx.doi.org/10.1038/srep05511

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047332268

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24981574


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immediate-Early Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Keelung Chang Gung Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.454209.e", 
          "name": [
            "Department of General Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiang", 
        "givenName": "Kun-Chun", 
        "id": "sg:person.01303361147.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303361147.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Urology, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsui", 
        "givenName": "Ke-Hung", 
        "id": "sg:person.01066141371.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066141371.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Anatomy, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Li-Chuan", 
        "id": "sg:person.01121025673.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121025673.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of General Surgery, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yeh", 
        "givenName": "Chun-Nan", 
        "id": "sg:person.0773114302.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773114302.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "School of Nursing, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Feng", 
        "givenName": "Tsui-Hsia", 
        "id": "sg:person.01255001543.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255001543.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "National Kaohsiung University of Hospitality and Tourism, Hsiao-Kang, Kaohsiung Taiwan R.O.C"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Wen-Tsung", 
        "id": "sg:person.0646051560.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646051560.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Urology, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chang", 
        "givenName": "Phei-Lang", 
        "id": "sg:person.01134254571.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134254571.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Anatomy, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiang", 
        "givenName": "Hou-Yu", 
        "id": "sg:person.01022013266.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022013266.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Anatomy, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Juang", 
        "givenName": "Horng-Heng", 
        "id": "sg:person.0724056073.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724056073.68"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0378-1119(01)00825-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001071835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-1462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001200840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14740338.4.6.1051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003675993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14740338.4.6.1051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003675993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2010.12.064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004305832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.26284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005223620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/febs.12711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007846368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.20725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007849446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008798576", 
          "https://doi.org/10.1038/onc.2011.384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0163-7258(87)90009-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010827839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0163-7258(87)90009-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010827839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015777547", 
          "https://doi.org/10.1038/sj.onc.1209347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015777547", 
          "https://doi.org/10.1038/sj.onc.1209347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2011.07.067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016096084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1303958110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020059973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020626779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022709260", 
          "https://doi.org/10.1038/sj.onc.1208008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022709260", 
          "https://doi.org/10.1038/sj.onc.1208008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1296-482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022899520", 
          "https://doi.org/10.1038/ng1296-482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2013.05.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023343150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-006-0080-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025477638", 
          "https://doi.org/10.1007/s00432-006-0080-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-006-0080-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025477638", 
          "https://doi.org/10.1007/s00432-006-0080-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025542873", 
          "https://doi.org/10.1038/sj.onc.1207346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025542873", 
          "https://doi.org/10.1038/sj.onc.1207346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00180.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026521512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0094-0143(05)70163-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026579236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0094-0143(05)70163-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026579236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026946552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000138053.78518.b2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028567828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000138053.78518.b2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028567828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000138053.78518.b2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028567828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028771627", 
          "https://doi.org/10.1038/sj.onc.1209942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028771627", 
          "https://doi.org/10.1038/sj.onc.1209942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-1033.2002.03052.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030472667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11033-009-9777-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031152887", 
          "https://doi.org/10.1007/s11033-009-9777-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11033-009-9777-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031152887", 
          "https://doi.org/10.1007/s11033-009-9777-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-6507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031428206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0305-7372(79)80057-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034123492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0089117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034844349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035533524", 
          "https://doi.org/10.1038/sj.onc.1206933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035533524", 
          "https://doi.org/10.1038/sj.onc.1206933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.2009.08345.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037232366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2744(200002)27:2<57::aid-mc1>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037294465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039639004", 
          "https://doi.org/10.1038/nrd2781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12672-012-0123-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043284868", 
          "https://doi.org/10.1007/s12672-012-0123-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1011379108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043614338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.21222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044792310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.21222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044792310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2004.05.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047822041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(02)00697-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049119367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-biophys-083012-130338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051680172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.03.061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.26.6.1597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071515741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or_00000089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071536897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077330404", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079570275", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-05", 
    "datePublishedReg": "2015-05-01", 
    "description": "Cisplatin is a widely used anti-cancer drug. The B-cell translocation gene 2 (BTG2) is involved in the cell cycle transition regulation. We evaluated the cisplatin effects on prostate cancer cell proliferation and the expressions of BTG2, p53, androgen receptor (AR) and prostate specific antigen (PSA) in prostate carcinoma, p53 wild-type LNCaP or p53-null PC-3, cells. Cisplatin treatments attenuated cell prostate cancer cell growth through inducing Go/G1 cell cycle arrest in lower concentration and apoptosis at higher dosage. Cisplatin treatments enhanced p53 and BTG2 expression, repressed AR and PSA expression, and blocked the activation of androgen on the PSA secretion in LNCaP cells. BTG2 knockdown in LNCaP cells attenuated cisplatin-mediated growth inhibition. Cisplatin enhanced BTG2 gene expression dependent on the DNA fragment located within -173 to -82 upstream of BTG2 translation initiation site in prostate cancer cells. Mutation of the p53 response element from GGGCAGAGCCC to GGGCACC or mutation of the NF\u03baB response element from GGAAAGTCC to GGAAAGGAA by site-directed mutagenesis abolished the stimulation of cisplatin on the BTG2 promoter activity in LNCaP or PC-3 cells, respectively. Our results indicated that cisplatin attenuates prostate cancer cell proliferation partly mediated by upregulation of BTG2 through the p53-dependent pathway or p53-independent NF\u03baB pathway. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep05511", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Cisplatin modulates B-cell translocation gene 2 to attenuate cell proliferation of prostate carcinoma cells in both p53-dependent and p53-independent pathways", 
    "pagination": "5511", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e179fa66ed6fdaeac8fd15f2bd1722e5cece2c3c0c09de2aeab61e256cd661f7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24981574"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep05511"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047332268"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep05511", 
      "https://app.dimensions.ai/details/publication/pub.1047332268"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2014/140701/srep05511/full/srep05511.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep05511'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep05511'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep05511'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep05511'


 

This table displays all metadata directly associated to this object as RDF triples.

334 TRIPLES      21 PREDICATES      86 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep05511 schema:about N19df4843cf8047ce838f81ed48774a2d
2 N403182fc69f14412809a06a73fffddfe
3 N666a181e83ec449fb7f66508c6854939
4 N72116153ca6646bda7d435c2dfc7fa7c
5 N7db8d82af88a4119b43066a0dbf8743d
6 N8f3882139c9c40e5bf9ea66234ac783f
7 N9ff70a4dedec4bf0a604bccc0dbd3008
8 Na061580743124340adb21f251665a7c2
9 Nb650e94300e4413482d794560c22f280
10 Nc257d9ae873741da9ec6c1ba248f5732
11 Nc51503aef8a54b36a9cafa55b2e34a8e
12 Ne7a0c3c1660f4b73a3a06f0297c1807c
13 Ned37ac91a53742bf9c23ebb580c914cd
14 Neece585a6f6f4eaaa67e11c270c14136
15 anzsrc-for:06
16 anzsrc-for:0601
17 schema:author N2feb232b15a146f9ab921a8e0a8d8b56
18 schema:citation sg:pub.10.1007/s00432-006-0080-1
19 sg:pub.10.1007/s11033-009-9777-y
20 sg:pub.10.1007/s12672-012-0123-9
21 sg:pub.10.1038/ng1296-482
22 sg:pub.10.1038/nrd2781
23 sg:pub.10.1038/onc.2011.384
24 sg:pub.10.1038/sj.onc.1206933
25 sg:pub.10.1038/sj.onc.1207346
26 sg:pub.10.1038/sj.onc.1208008
27 sg:pub.10.1038/sj.onc.1209347
28 sg:pub.10.1038/sj.onc.1209942
29 https://app.dimensions.ai/details/publication/pub.1077330404
30 https://app.dimensions.ai/details/publication/pub.1079570275
31 https://doi.org/10.1002/(sici)1098-2744(200002)27:2<57::aid-mc1>3.0.co;2-i
32 https://doi.org/10.1002/ijc.26284
33 https://doi.org/10.1002/jcp.1062
34 https://doi.org/10.1002/pros.20725
35 https://doi.org/10.1002/pros.21222
36 https://doi.org/10.1016/0163-7258(87)90009-x
37 https://doi.org/10.1016/j.bbrc.2010.12.064
38 https://doi.org/10.1016/j.canlet.2013.05.028
39 https://doi.org/10.1016/j.eururo.2011.07.067
40 https://doi.org/10.1016/j.yexcr.2004.05.014
41 https://doi.org/10.1016/s0094-0143(05)70163-4
42 https://doi.org/10.1016/s0305-7372(79)80057-2
43 https://doi.org/10.1016/s0378-1119(01)00825-3
44 https://doi.org/10.1016/s1097-2765(02)00697-4
45 https://doi.org/10.1046/j.1432-1033.2002.03052.x
46 https://doi.org/10.1073/pnas.1011379108
47 https://doi.org/10.1073/pnas.1303958110
48 https://doi.org/10.1097/01.ju.0000138053.78518.b2
49 https://doi.org/10.1111/febs.12711
50 https://doi.org/10.1111/j.1464-410x.2009.08345.x
51 https://doi.org/10.1146/annurev-biophys-083012-130338
52 https://doi.org/10.1152/ajpcell.00180.2011
53 https://doi.org/10.1158/0008-5472.can-07-6507
54 https://doi.org/10.1158/1078-0432.ccr-04-1462
55 https://doi.org/10.1200/jco.2002.03.061
56 https://doi.org/10.1371/journal.pone.0089117
57 https://doi.org/10.1517/14740338.4.6.1051
58 https://doi.org/10.3322/caac.20138
59 https://doi.org/10.3892/ijo.26.6.1597
60 https://doi.org/10.3892/or_00000089
61 schema:datePublished 2015-05
62 schema:datePublishedReg 2015-05-01
63 schema:description Cisplatin is a widely used anti-cancer drug. The B-cell translocation gene 2 (BTG2) is involved in the cell cycle transition regulation. We evaluated the cisplatin effects on prostate cancer cell proliferation and the expressions of BTG2, p53, androgen receptor (AR) and prostate specific antigen (PSA) in prostate carcinoma, p53 wild-type LNCaP or p53-null PC-3, cells. Cisplatin treatments attenuated cell prostate cancer cell growth through inducing Go/G1 cell cycle arrest in lower concentration and apoptosis at higher dosage. Cisplatin treatments enhanced p53 and BTG2 expression, repressed AR and PSA expression, and blocked the activation of androgen on the PSA secretion in LNCaP cells. BTG2 knockdown in LNCaP cells attenuated cisplatin-mediated growth inhibition. Cisplatin enhanced BTG2 gene expression dependent on the DNA fragment located within -173 to -82 upstream of BTG2 translation initiation site in prostate cancer cells. Mutation of the p53 response element from GGGCAGAGCCC to GGGCACC or mutation of the NFκB response element from GGAAAGTCC to GGAAAGGAA by site-directed mutagenesis abolished the stimulation of cisplatin on the BTG2 promoter activity in LNCaP or PC-3 cells, respectively. Our results indicated that cisplatin attenuates prostate cancer cell proliferation partly mediated by upregulation of BTG2 through the p53-dependent pathway or p53-independent NFκB pathway.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf Nabf6e89ec9b84cf5874ec21304107323
68 Nc75da19a394b4c14a06f9707518fb445
69 sg:journal.1045337
70 schema:name Cisplatin modulates B-cell translocation gene 2 to attenuate cell proliferation of prostate carcinoma cells in both p53-dependent and p53-independent pathways
71 schema:pagination 5511
72 schema:productId N343333162eec4709a3f561a5bd859cb2
73 N3e964b8beced49799194e6e2b54025fe
74 N824e4e9a08714fdf8c0c32c4a3ebc301
75 N94a54f901d6f43b89b77f52b73472450
76 Nae05e72d132b43a485d13ec4f3676e34
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047332268
78 https://doi.org/10.1038/srep05511
79 schema:sdDatePublished 2019-04-10T17:19
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher Na1b846d5e0f54772b906d6ee4f392814
82 schema:url http://www.nature.com/srep/2014/140701/srep05511/full/srep05511.html
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N0754fe28c13d45af8a56c604773dd68a rdf:first sg:person.01022013266.88
87 rdf:rest Nb56b39e4a09e45238040e21d0fc8254c
88 N19df4843cf8047ce838f81ed48774a2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Treatment Outcome
90 rdf:type schema:DefinedTerm
91 N2feb232b15a146f9ab921a8e0a8d8b56 rdf:first sg:person.01303361147.20
92 rdf:rest N63ad1f4e806b4a3d97d8ddc4f650121b
93 N343333162eec4709a3f561a5bd859cb2 schema:name pubmed_id
94 schema:value 24981574
95 rdf:type schema:PropertyValue
96 N3e964b8beced49799194e6e2b54025fe schema:name doi
97 schema:value 10.1038/srep05511
98 rdf:type schema:PropertyValue
99 N403182fc69f14412809a06a73fffddfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Tumor Suppressor Protein p53
101 rdf:type schema:DefinedTerm
102 N4fe73d8013b14387a6dfbd1f3e6014f3 rdf:first sg:person.0646051560.43
103 rdf:rest N85098f9d9f4842528de3b67355ea2b38
104 N549b42325df0461bb6e460f481336cee schema:name Department of Anatomy, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, ROC
105 rdf:type schema:Organization
106 N63ad1f4e806b4a3d97d8ddc4f650121b rdf:first sg:person.01066141371.31
107 rdf:rest N658b78ada78444a18bdbee52d7df6537
108 N658b78ada78444a18bdbee52d7df6537 rdf:first sg:person.01121025673.48
109 rdf:rest Nf05e36dc6c414496b2220a1df2e790ee
110 N666a181e83ec449fb7f66508c6854939 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Signal Transduction
112 rdf:type schema:DefinedTerm
113 N706855ec8dd14bf2a97d6c079eec99fe schema:name Department of Urology, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan, ROC
114 rdf:type schema:Organization
115 N72116153ca6646bda7d435c2dfc7fa7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Male
117 rdf:type schema:DefinedTerm
118 N7db8d82af88a4119b43066a0dbf8743d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Humans
120 rdf:type schema:DefinedTerm
121 N824e4e9a08714fdf8c0c32c4a3ebc301 schema:name nlm_unique_id
122 schema:value 101563288
123 rdf:type schema:PropertyValue
124 N85098f9d9f4842528de3b67355ea2b38 rdf:first sg:person.01134254571.80
125 rdf:rest N0754fe28c13d45af8a56c604773dd68a
126 N8f3882139c9c40e5bf9ea66234ac783f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Cell Line, Tumor
128 rdf:type schema:DefinedTerm
129 N8fedf76d84fb4937a3285dc345f474cc schema:name School of Nursing, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, ROC
130 rdf:type schema:Organization
131 N94a54f901d6f43b89b77f52b73472450 schema:name dimensions_id
132 schema:value pub.1047332268
133 rdf:type schema:PropertyValue
134 N9ff70a4dedec4bf0a604bccc0dbd3008 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Cell Proliferation
136 rdf:type schema:DefinedTerm
137 Na061580743124340adb21f251665a7c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Protein-Serine-Threonine Kinases
139 rdf:type schema:DefinedTerm
140 Na1b846d5e0f54772b906d6ee4f392814 schema:name Springer Nature - SN SciGraph project
141 rdf:type schema:Organization
142 Nabf6e89ec9b84cf5874ec21304107323 schema:volumeNumber 4
143 rdf:type schema:PublicationVolume
144 Nae05e72d132b43a485d13ec4f3676e34 schema:name readcube_id
145 schema:value e179fa66ed6fdaeac8fd15f2bd1722e5cece2c3c0c09de2aeab61e256cd661f7
146 rdf:type schema:PropertyValue
147 Nb56b39e4a09e45238040e21d0fc8254c rdf:first sg:person.0724056073.68
148 rdf:rest rdf:nil
149 Nb650e94300e4413482d794560c22f280 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Cisplatin
151 rdf:type schema:DefinedTerm
152 Nbecc7258f1aa4a51a64ee428dab6f4eb schema:name Department of Anatomy, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, ROC
153 rdf:type schema:Organization
154 Nc122abfb36e1447798e55f91438be056 schema:name Department of Anatomy, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, ROC
155 rdf:type schema:Organization
156 Nc257d9ae873741da9ec6c1ba248f5732 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Antineoplastic Agents
158 rdf:type schema:DefinedTerm
159 Nc51503aef8a54b36a9cafa55b2e34a8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Immediate-Early Proteins
161 rdf:type schema:DefinedTerm
162 Nc5a8247a472f4fce87ae4fc45c69bb35 rdf:first sg:person.01255001543.50
163 rdf:rest N4fe73d8013b14387a6dfbd1f3e6014f3
164 Nc75da19a394b4c14a06f9707518fb445 schema:issueNumber 1
165 rdf:type schema:PublicationIssue
166 Ne014cb465ff0408a96415faaf0cf282d schema:name Department of Urology, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan, ROC
167 rdf:type schema:Organization
168 Ne19eff640e9b4ace9125f854b40dbf96 schema:name Department of General Surgery, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan, ROC
169 rdf:type schema:Organization
170 Ne7a0c3c1660f4b73a3a06f0297c1807c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Prostatic Neoplasms
172 rdf:type schema:DefinedTerm
173 Ne9d6e7eb030e4af9ab558c4d3721a514 schema:name National Kaohsiung University of Hospitality and Tourism, Hsiao-Kang, Kaohsiung Taiwan R.O.C
174 rdf:type schema:Organization
175 Ned37ac91a53742bf9c23ebb580c914cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Tumor Suppressor Proteins
177 rdf:type schema:DefinedTerm
178 Neece585a6f6f4eaaa67e11c270c14136 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Dose-Response Relationship, Drug
180 rdf:type schema:DefinedTerm
181 Nf05e36dc6c414496b2220a1df2e790ee rdf:first sg:person.0773114302.82
182 rdf:rest Nc5a8247a472f4fce87ae4fc45c69bb35
183 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
184 schema:name Biological Sciences
185 rdf:type schema:DefinedTerm
186 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
187 schema:name Biochemistry and Cell Biology
188 rdf:type schema:DefinedTerm
189 sg:journal.1045337 schema:issn 2045-2322
190 schema:name Scientific Reports
191 rdf:type schema:Periodical
192 sg:person.01022013266.88 schema:affiliation Nc122abfb36e1447798e55f91438be056
193 schema:familyName Chiang
194 schema:givenName Hou-Yu
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022013266.88
196 rdf:type schema:Person
197 sg:person.01066141371.31 schema:affiliation N706855ec8dd14bf2a97d6c079eec99fe
198 schema:familyName Tsui
199 schema:givenName Ke-Hung
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066141371.31
201 rdf:type schema:Person
202 sg:person.01121025673.48 schema:affiliation Nbecc7258f1aa4a51a64ee428dab6f4eb
203 schema:familyName Chung
204 schema:givenName Li-Chuan
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121025673.48
206 rdf:type schema:Person
207 sg:person.01134254571.80 schema:affiliation Ne014cb465ff0408a96415faaf0cf282d
208 schema:familyName Chang
209 schema:givenName Phei-Lang
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134254571.80
211 rdf:type schema:Person
212 sg:person.01255001543.50 schema:affiliation N8fedf76d84fb4937a3285dc345f474cc
213 schema:familyName Feng
214 schema:givenName Tsui-Hsia
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255001543.50
216 rdf:type schema:Person
217 sg:person.01303361147.20 schema:affiliation https://www.grid.ac/institutes/grid.454209.e
218 schema:familyName Chiang
219 schema:givenName Kun-Chun
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303361147.20
221 rdf:type schema:Person
222 sg:person.0646051560.43 schema:affiliation Ne9d6e7eb030e4af9ab558c4d3721a514
223 schema:familyName Chen
224 schema:givenName Wen-Tsung
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646051560.43
226 rdf:type schema:Person
227 sg:person.0724056073.68 schema:affiliation N549b42325df0461bb6e460f481336cee
228 schema:familyName Juang
229 schema:givenName Horng-Heng
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724056073.68
231 rdf:type schema:Person
232 sg:person.0773114302.82 schema:affiliation Ne19eff640e9b4ace9125f854b40dbf96
233 schema:familyName Yeh
234 schema:givenName Chun-Nan
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773114302.82
236 rdf:type schema:Person
237 sg:pub.10.1007/s00432-006-0080-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025477638
238 https://doi.org/10.1007/s00432-006-0080-1
239 rdf:type schema:CreativeWork
240 sg:pub.10.1007/s11033-009-9777-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1031152887
241 https://doi.org/10.1007/s11033-009-9777-y
242 rdf:type schema:CreativeWork
243 sg:pub.10.1007/s12672-012-0123-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043284868
244 https://doi.org/10.1007/s12672-012-0123-9
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/ng1296-482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022899520
247 https://doi.org/10.1038/ng1296-482
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/nrd2781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039639004
250 https://doi.org/10.1038/nrd2781
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/onc.2011.384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008798576
253 https://doi.org/10.1038/onc.2011.384
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/sj.onc.1206933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035533524
256 https://doi.org/10.1038/sj.onc.1206933
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/sj.onc.1207346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025542873
259 https://doi.org/10.1038/sj.onc.1207346
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/sj.onc.1208008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022709260
262 https://doi.org/10.1038/sj.onc.1208008
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/sj.onc.1209347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015777547
265 https://doi.org/10.1038/sj.onc.1209347
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/sj.onc.1209942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028771627
268 https://doi.org/10.1038/sj.onc.1209942
269 rdf:type schema:CreativeWork
270 https://app.dimensions.ai/details/publication/pub.1077330404 schema:CreativeWork
271 https://app.dimensions.ai/details/publication/pub.1079570275 schema:CreativeWork
272 https://doi.org/10.1002/(sici)1098-2744(200002)27:2<57::aid-mc1>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1037294465
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1002/ijc.26284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005223620
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1002/jcp.1062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026946552
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1002/pros.20725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007849446
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1002/pros.21222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044792310
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/0163-7258(87)90009-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010827839
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.bbrc.2010.12.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004305832
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.canlet.2013.05.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023343150
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.eururo.2011.07.067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016096084
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.yexcr.2004.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047822041
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/s0094-0143(05)70163-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026579236
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/s0305-7372(79)80057-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034123492
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/s0378-1119(01)00825-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001071835
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/s1097-2765(02)00697-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049119367
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1046/j.1432-1033.2002.03052.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030472667
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1073/pnas.1011379108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043614338
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1073/pnas.1303958110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020059973
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1097/01.ju.0000138053.78518.b2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028567828
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1111/febs.12711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007846368
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1111/j.1464-410x.2009.08345.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037232366
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1146/annurev-biophys-083012-130338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051680172
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1152/ajpcell.00180.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026521512
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1158/0008-5472.can-07-6507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031428206
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1158/1078-0432.ccr-04-1462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001200840
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1200/jco.2002.03.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202957
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1371/journal.pone.0089117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034844349
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1517/14740338.4.6.1051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003675993
325 rdf:type schema:CreativeWork
326 https://doi.org/10.3322/caac.20138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020626779
327 rdf:type schema:CreativeWork
328 https://doi.org/10.3892/ijo.26.6.1597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071515741
329 rdf:type schema:CreativeWork
330 https://doi.org/10.3892/or_00000089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071536897
331 rdf:type schema:CreativeWork
332 https://www.grid.ac/institutes/grid.454209.e schema:alternateName Keelung Chang Gung Memorial Hospital
333 schema:name Department of General Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan, ROC
334 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...