Cytotoxic activity of acyl phloroglucinols isolated from the leaves of Eucalyptus cinerea F. Muell. ex Benth. cultivated in Egypt View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-05

AUTHORS

Fathy M Soliman, Magda M Fathy, Maha M Salama, Ahmed M Al-Abd, Fatema R Saber, Ali M El-Halawany

ABSTRACT

Two acyl phloroglucinol compounds namely; Sideroxylonal B (1) and Macrocarpal A (2) were isolated from the Sideroxylonal-Rich Extract (SRE) of the juvenile leaves of Eucalyptus cinerea; F. Muell. ex Benth cultivated in Egypt. Identification of the isolated compounds was established on the basis of physico-chemical properties and spectral analysis (1D & 2D NMR). The two compounds were isolated for the first time from this species. The SRE alongside with the isolated compounds were tested against three human cancer cell lines; MCF7 (breast carcinoma cell line), HEP2 (laryngeal carcinoma), CaCo (colonic adenocarcinoma) and one type of normal human cell line;10 FS (fibroblast cells). The SRE, (1), and (2) showed cytotoxic activity with IC₅₀ 13.6 ± 0.62, 7.2 ± 0.5, 14.8 ± 0.55 μg mL-1 against HEP2 respectively, 11.6 ± 0.47, 4 ± 0.36, 11.4 ± 0.45 μg mL-1 against CaCo, respectively, and 8.6 ± 0.29, 4.4 ± 0.25, and 7.8 ± 0.3 μg mL-1 against MCF7, respectively. Meanwhile, the (SRE) together with (1) and (2) exhibited low cytotoxicity against normal cell line 10 FS, with IC₅₀ 55.4 ± 1.4, 43 ± 0.8 and 50.1 ± 1.12 μg mL-1, respectively. The antiprofilerative activity of the tested compounds was evaluated. The cell cycle profile of cells treated with Sideroxylonal-B and Macrocarpal-A indicates possible S-phase specific effects. More... »

PAGES

5410

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep05410

DOI

http://dx.doi.org/10.1038/srep05410

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042876815

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24986654


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