Protective role of TNF-α, IL-10 and IL-2 in mice infected with the Oshima strain of Tick-borne encephalitis virus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-05

AUTHORS

Mya Myat Ngwe Tun, Kotaro Aoki, Masachika Senba, Corazon C Buerano, Kenji Shirai, Ryuji Suzuki, Kouichi Morita, Daisuke Hayasaka

ABSTRACT

Tick-borne encephalitis virus (TBEV) causes acute central nervous system disease. Here, we investigated the roles of the TNF-α, IL-10 and other cytokines in appropriate KO mice following infection with Oshima and Sofjin strains of TBEV. Following infection with the Oshima strain, mortality rates were significantly increased in TNF-α KO and IL-10 KO mice compared with wild type (WT) mice. These results suggested that TNF-α and IL-10 play protective roles against fatal infection due to Oshima strain infection. However, viral loads and proinflammatory cytokine levels in the brain of TNF-α KO andIL-10 KO mice were not significantly different compared with those of WT mice. On the other hand, all WT, TNF-α KO and IL-10 KO mice died following infection with Sofjin strain. Interestingly, Sofjin-infected mice did not exhibit an up-regulated mRNA level of IL-2 in the spleen in all groups of mice, whereas Oshima-infected mice showed significantly increased level of IL-2 compared with mock-infected mice. From these results, we suggest that TNF-α, IL-10 and IL-2 are key factors for disease remission from fatal encephalitis due to infection with Oshima strain of TBEV. More... »

PAGES

5344

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep05344

DOI

http://dx.doi.org/10.1038/srep05344

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016134090

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24938868


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Encephalitis Viruses, Tick-Borne", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Encephalitis, Tick-Borne", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Host-Pathogen Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation Mediators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-10", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protective Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Species Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Load", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nagasaki University", 
          "id": "https://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Virology, Institute of Tropical Medicine, Leading Graduate School Program, Nagasaki University, 852-8523, Nagasaki, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tun", 
        "givenName": "Mya Myat Ngwe", 
        "id": "sg:person.01055170264.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055170264.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagasaki University", 
          "id": "https://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Virology, Institute of Tropical Medicine, Leading Graduate School Program, Nagasaki University, 852-8523, Nagasaki, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoki", 
        "givenName": "Kotaro", 
        "id": "sg:person.01011221732.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011221732.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagasaki University", 
          "id": "https://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Pathology, Institute of Tropical Medicine, Leading Graduate School Program, Nagasaki University, 852-8523, Nagasaki, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Senba", 
        "givenName": "Masachika", 
        "id": "sg:person.01046072252.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046072252.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagasaki University", 
          "id": "https://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Virology, Institute of Tropical Medicine, Leading Graduate School Program, Nagasaki University, 852-8523, Nagasaki, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buerano", 
        "givenName": "Corazon C", 
        "id": "sg:person.01030473775.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030473775.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Sagamihara Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415689.7", 
          "name": [
            "Clinical Research Center, National Hospital Organization Sagamihara Hospital, Sakuradai 18-1, Sagamihara, Kanagawa 228-8522, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shirai", 
        "givenName": "Kenji", 
        "id": "sg:person.01227360657.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227360657.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Sagamihara Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415689.7", 
          "name": [
            "Clinical Research Center, National Hospital Organization Sagamihara Hospital, Sakuradai 18-1, Sagamihara, Kanagawa 228-8522, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Ryuji", 
        "id": "sg:person.012211775722.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012211775722.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagasaki University", 
          "id": "https://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Virology, Institute of Tropical Medicine, Leading Graduate School Program, Nagasaki University, 852-8523, Nagasaki, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morita", 
        "givenName": "Kouichi", 
        "id": "sg:person.011552554042.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011552554042.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagasaki University", 
          "id": "https://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Virology, Institute of Tropical Medicine, Leading Graduate School Program, Nagasaki University, 852-8523, Nagasaki, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayasaka", 
        "givenName": "Daisuke", 
        "id": "sg:person.0775573172.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775573172.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)60800-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000885508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2009.04.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001452726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.79.7.4460-4469.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002668986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0300985810372507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005420493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0300985810372507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005420493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01118-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011758156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virusres.2005.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012244956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0264-410x(02)00819-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019311942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0264-410x(02)00819-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019311942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0264-410x(98)00262-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046902940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.184.4.1397", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047185615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.00447-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050089197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0071643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050376371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-1759(01)00489-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053397968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/515195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058789585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/vbz.2008.0153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059324715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/vim.2011.0017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059327086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/0022-1317-80-1-179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060360992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/vir.0.060046-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060399445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077596197", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-05", 
    "datePublishedReg": "2015-05-01", 
    "description": "Tick-borne encephalitis virus (TBEV) causes acute central nervous system disease. Here, we investigated the roles of the TNF-\u03b1, IL-10 and other cytokines in appropriate KO mice following infection with Oshima and Sofjin strains of TBEV. Following infection with the Oshima strain, mortality rates were significantly increased in TNF-\u03b1 KO and IL-10 KO mice compared with wild type (WT) mice. These results suggested that TNF-\u03b1 and IL-10 play protective roles against fatal infection due to Oshima strain infection. However, viral loads and proinflammatory cytokine levels in the brain of TNF-\u03b1 KO andIL-10 KO mice were not significantly different compared with those of WT mice. On the other hand, all WT, TNF-\u03b1 KO and IL-10 KO mice died following infection with Sofjin strain. Interestingly, Sofjin-infected mice did not exhibit an up-regulated mRNA level of IL-2 in the spleen in all groups of mice, whereas Oshima-infected mice showed significantly increased level of IL-2 compared with mock-infected mice. From these results, we suggest that TNF-\u03b1, IL-10 and IL-2 are key factors for disease remission from fatal encephalitis due to infection with Oshima strain of TBEV. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep05344", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6124940", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6091241", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6110836", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6075879", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Protective role of TNF-\u03b1, IL-10 and IL-2 in mice infected with the Oshima strain of Tick-borne encephalitis virus", 
    "pagination": "5344", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4cdff19f0f11640e59b730e243c2d96cac8c02c029efcff723c78f9db2d0e53d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24938868"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep05344"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016134090"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep05344", 
      "https://app.dimensions.ai/details/publication/pub.1016134090"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2014/140618/srep05344/full/srep05344.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep05344'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep05344'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep05344'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep05344'


 

This table displays all metadata directly associated to this object as RDF triples.

266 TRIPLES      21 PREDICATES      68 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep05344 schema:about N00d2059d0eeb4b2eb6e98aa176f08906
2 N13c9e82a3cfe4265afb74b744302bf04
3 N149b31dd4f33419aa80234b0e564abc0
4 N176a2da8e2264813a9a874a70fbf1e01
5 N201c40ebe0d34bc889f8a0c4e3139d2f
6 N272740b9df664083a43dc2832f54f476
7 N2bb7ab6352df4683b330c951f8455e3e
8 N51ce217ff9874e1d9afb0f7857884f91
9 N59d7f215682547a6bf255c86fae38057
10 N5b16b8c9d8274bd9b01c9c3228bbd61e
11 N68e46e1dc0084c629b47fe8d1e617faa
12 N79ad5ecc7e184bf0a073a2e007bc901b
13 N90eac7b723e046c2a169f0d4b37d21e3
14 N9e5644cf7c9d42a4abecb8781ef38374
15 Na7813caac1e84b43a4f2326579295cdd
16 Nae310379179f4baf9a25b0e4fbcb2e71
17 Nb896ce22bfe54c93972d457dbb511a07
18 Nc9a394e6b1e34d4ea66058883359a234
19 Nda0390bb93da4b3ea1a679f3b529de53
20 Nf75a6300dfcf451ba59e50ac05b97cf5
21 Nfeab89777b42402090c00d8fc3de98f6
22 anzsrc-for:11
23 anzsrc-for:1108
24 schema:author N5816c2365dad41f891726225268751a8
25 schema:citation https://app.dimensions.ai/details/publication/pub.1077596197
26 https://doi.org/10.1016/j.virol.2009.04.026
27 https://doi.org/10.1016/j.virusres.2005.04.007
28 https://doi.org/10.1016/s0022-1759(01)00489-6
29 https://doi.org/10.1016/s0140-6736(08)60800-4
30 https://doi.org/10.1016/s0264-410x(02)00819-8
31 https://doi.org/10.1016/s0264-410x(98)00262-x
32 https://doi.org/10.1084/jem.184.4.1397
33 https://doi.org/10.1086/515195
34 https://doi.org/10.1089/vbz.2008.0153
35 https://doi.org/10.1089/vim.2011.0017
36 https://doi.org/10.1099/0022-1317-80-1-179
37 https://doi.org/10.1099/vir.0.060046-0
38 https://doi.org/10.1128/iai.00447-06
39 https://doi.org/10.1128/jvi.01118-08
40 https://doi.org/10.1128/jvi.79.7.4460-4469.2005
41 https://doi.org/10.1177/0300985810372507
42 https://doi.org/10.1371/journal.pone.0071643
43 schema:datePublished 2015-05
44 schema:datePublishedReg 2015-05-01
45 schema:description Tick-borne encephalitis virus (TBEV) causes acute central nervous system disease. Here, we investigated the roles of the TNF-α, IL-10 and other cytokines in appropriate KO mice following infection with Oshima and Sofjin strains of TBEV. Following infection with the Oshima strain, mortality rates were significantly increased in TNF-α KO and IL-10 KO mice compared with wild type (WT) mice. These results suggested that TNF-α and IL-10 play protective roles against fatal infection due to Oshima strain infection. However, viral loads and proinflammatory cytokine levels in the brain of TNF-α KO andIL-10 KO mice were not significantly different compared with those of WT mice. On the other hand, all WT, TNF-α KO and IL-10 KO mice died following infection with Sofjin strain. Interestingly, Sofjin-infected mice did not exhibit an up-regulated mRNA level of IL-2 in the spleen in all groups of mice, whereas Oshima-infected mice showed significantly increased level of IL-2 compared with mock-infected mice. From these results, we suggest that TNF-α, IL-10 and IL-2 are key factors for disease remission from fatal encephalitis due to infection with Oshima strain of TBEV.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree true
49 schema:isPartOf N7737aa016c0c4ecbb2e17429a481f745
50 N7d264d73f7d542cb8ccb97e6d0dd0a2a
51 sg:journal.1045337
52 schema:name Protective role of TNF-α, IL-10 and IL-2 in mice infected with the Oshima strain of Tick-borne encephalitis virus
53 schema:pagination 5344
54 schema:productId N52e8cf80015c4bf79ccc2e9ce9cbaf99
55 N774832b3505e46bc8e3f6f612a8a6a02
56 N7eeb6231a5f04eb9bd5cbcae9cd0f18b
57 Nf23f869634e846819a18d13d4830ad35
58 Nfcaaf3f9f8164ec2b17c9f3d5f96d008
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016134090
60 https://doi.org/10.1038/srep05344
61 schema:sdDatePublished 2019-04-10T13:55
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher Nf355c260848943a5b02ebabfced8bb7b
64 schema:url http://www.nature.com/srep/2014/140618/srep05344/full/srep05344.html
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N00d2059d0eeb4b2eb6e98aa176f08906 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Time Factors
70 rdf:type schema:DefinedTerm
71 N0fe9b28b0dd040e9b21bce914bc370dd rdf:first sg:person.012211775722.37
72 rdf:rest N8511a1a7df0446dc9f274290b8d2e768
73 N13c9e82a3cfe4265afb74b744302bf04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Gene Expression
75 rdf:type schema:DefinedTerm
76 N149b31dd4f33419aa80234b0e564abc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Interleukin-2
78 rdf:type schema:DefinedTerm
79 N176a2da8e2264813a9a874a70fbf1e01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Species Specificity
81 rdf:type schema:DefinedTerm
82 N201c40ebe0d34bc889f8a0c4e3139d2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Inflammation Mediators
84 rdf:type schema:DefinedTerm
85 N253b4ff1959644afb9f5ac14fc07c8b2 rdf:first sg:person.01030473775.99
86 rdf:rest N5d3f89f087294323a4c0637428671ab3
87 N272740b9df664083a43dc2832f54f476 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Survival Rate
89 rdf:type schema:DefinedTerm
90 N2bb7ab6352df4683b330c951f8455e3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Animals
92 rdf:type schema:DefinedTerm
93 N51ce217ff9874e1d9afb0f7857884f91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Reverse Transcriptase Polymerase Chain Reaction
95 rdf:type schema:DefinedTerm
96 N52e8cf80015c4bf79ccc2e9ce9cbaf99 schema:name pubmed_id
97 schema:value 24938868
98 rdf:type schema:PropertyValue
99 N5816c2365dad41f891726225268751a8 rdf:first sg:person.01055170264.26
100 rdf:rest Nc541bc68a06f46698a70d47bb10d08fe
101 N59d7f215682547a6bf255c86fae38057 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Protective Agents
103 rdf:type schema:DefinedTerm
104 N5b16b8c9d8274bd9b01c9c3228bbd61e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Encephalitis, Tick-Borne
106 rdf:type schema:DefinedTerm
107 N5d3f89f087294323a4c0637428671ab3 rdf:first sg:person.01227360657.06
108 rdf:rest N0fe9b28b0dd040e9b21bce914bc370dd
109 N68e46e1dc0084c629b47fe8d1e617faa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Brain
111 rdf:type schema:DefinedTerm
112 N7737aa016c0c4ecbb2e17429a481f745 schema:volumeNumber 4
113 rdf:type schema:PublicationVolume
114 N774832b3505e46bc8e3f6f612a8a6a02 schema:name readcube_id
115 schema:value 4cdff19f0f11640e59b730e243c2d96cac8c02c029efcff723c78f9db2d0e53d
116 rdf:type schema:PropertyValue
117 N79ad5ecc7e184bf0a073a2e007bc901b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Viral Load
119 rdf:type schema:DefinedTerm
120 N7d264d73f7d542cb8ccb97e6d0dd0a2a schema:issueNumber 1
121 rdf:type schema:PublicationIssue
122 N7eeb6231a5f04eb9bd5cbcae9cd0f18b schema:name nlm_unique_id
123 schema:value 101563288
124 rdf:type schema:PropertyValue
125 N8511a1a7df0446dc9f274290b8d2e768 rdf:first sg:person.011552554042.56
126 rdf:rest Naa45af26ea6f452384a3b9b842273a78
127 N90eac7b723e046c2a169f0d4b37d21e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Interleukin-10
129 rdf:type schema:DefinedTerm
130 N9e5644cf7c9d42a4abecb8781ef38374 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Host-Pathogen Interactions
132 rdf:type schema:DefinedTerm
133 Na7813caac1e84b43a4f2326579295cdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Encephalitis Viruses, Tick-Borne
135 rdf:type schema:DefinedTerm
136 Naa45af26ea6f452384a3b9b842273a78 rdf:first sg:person.0775573172.34
137 rdf:rest rdf:nil
138 Nae310379179f4baf9a25b0e4fbcb2e71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Tumor Necrosis Factor-alpha
140 rdf:type schema:DefinedTerm
141 Nb896ce22bfe54c93972d457dbb511a07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Mice, Knockout
143 rdf:type schema:DefinedTerm
144 Nbeebef2b5ef944bc953d3eb1507e8383 rdf:first sg:person.01046072252.72
145 rdf:rest N253b4ff1959644afb9f5ac14fc07c8b2
146 Nc541bc68a06f46698a70d47bb10d08fe rdf:first sg:person.01011221732.72
147 rdf:rest Nbeebef2b5ef944bc953d3eb1507e8383
148 Nc9a394e6b1e34d4ea66058883359a234 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Cells, Cultured
150 rdf:type schema:DefinedTerm
151 Nda0390bb93da4b3ea1a679f3b529de53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Cytokines
153 rdf:type schema:DefinedTerm
154 Nf23f869634e846819a18d13d4830ad35 schema:name dimensions_id
155 schema:value pub.1016134090
156 rdf:type schema:PropertyValue
157 Nf355c260848943a5b02ebabfced8bb7b schema:name Springer Nature - SN SciGraph project
158 rdf:type schema:Organization
159 Nf75a6300dfcf451ba59e50ac05b97cf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name RNA, Messenger
161 rdf:type schema:DefinedTerm
162 Nfcaaf3f9f8164ec2b17c9f3d5f96d008 schema:name doi
163 schema:value 10.1038/srep05344
164 rdf:type schema:PropertyValue
165 Nfeab89777b42402090c00d8fc3de98f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Mice, Inbred C57BL
167 rdf:type schema:DefinedTerm
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
172 schema:name Medical Microbiology
173 rdf:type schema:DefinedTerm
174 sg:grant.6075879 http://pending.schema.org/fundedItem sg:pub.10.1038/srep05344
175 rdf:type schema:MonetaryGrant
176 sg:grant.6091241 http://pending.schema.org/fundedItem sg:pub.10.1038/srep05344
177 rdf:type schema:MonetaryGrant
178 sg:grant.6110836 http://pending.schema.org/fundedItem sg:pub.10.1038/srep05344
179 rdf:type schema:MonetaryGrant
180 sg:grant.6124940 http://pending.schema.org/fundedItem sg:pub.10.1038/srep05344
181 rdf:type schema:MonetaryGrant
182 sg:journal.1045337 schema:issn 2045-2322
183 schema:name Scientific Reports
184 rdf:type schema:Periodical
185 sg:person.01011221732.72 schema:affiliation https://www.grid.ac/institutes/grid.174567.6
186 schema:familyName Aoki
187 schema:givenName Kotaro
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011221732.72
189 rdf:type schema:Person
190 sg:person.01030473775.99 schema:affiliation https://www.grid.ac/institutes/grid.174567.6
191 schema:familyName Buerano
192 schema:givenName Corazon C
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030473775.99
194 rdf:type schema:Person
195 sg:person.01046072252.72 schema:affiliation https://www.grid.ac/institutes/grid.174567.6
196 schema:familyName Senba
197 schema:givenName Masachika
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046072252.72
199 rdf:type schema:Person
200 sg:person.01055170264.26 schema:affiliation https://www.grid.ac/institutes/grid.174567.6
201 schema:familyName Tun
202 schema:givenName Mya Myat Ngwe
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055170264.26
204 rdf:type schema:Person
205 sg:person.011552554042.56 schema:affiliation https://www.grid.ac/institutes/grid.174567.6
206 schema:familyName Morita
207 schema:givenName Kouichi
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011552554042.56
209 rdf:type schema:Person
210 sg:person.012211775722.37 schema:affiliation https://www.grid.ac/institutes/grid.415689.7
211 schema:familyName Suzuki
212 schema:givenName Ryuji
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012211775722.37
214 rdf:type schema:Person
215 sg:person.01227360657.06 schema:affiliation https://www.grid.ac/institutes/grid.415689.7
216 schema:familyName Shirai
217 schema:givenName Kenji
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227360657.06
219 rdf:type schema:Person
220 sg:person.0775573172.34 schema:affiliation https://www.grid.ac/institutes/grid.174567.6
221 schema:familyName Hayasaka
222 schema:givenName Daisuke
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775573172.34
224 rdf:type schema:Person
225 https://app.dimensions.ai/details/publication/pub.1077596197 schema:CreativeWork
226 https://doi.org/10.1016/j.virol.2009.04.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001452726
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.virusres.2005.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012244956
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s0022-1759(01)00489-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053397968
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0140-6736(08)60800-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000885508
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0264-410x(02)00819-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019311942
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0264-410x(98)00262-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046902940
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1084/jem.184.4.1397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047185615
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1086/515195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058789585
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1089/vbz.2008.0153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059324715
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1089/vim.2011.0017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059327086
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1099/0022-1317-80-1-179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060360992
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1099/vir.0.060046-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060399445
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1128/iai.00447-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050089197
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1128/jvi.01118-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011758156
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1128/jvi.79.7.4460-4469.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002668986
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1177/0300985810372507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005420493
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1371/journal.pone.0071643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050376371
259 rdf:type schema:CreativeWork
260 https://www.grid.ac/institutes/grid.174567.6 schema:alternateName Nagasaki University
261 schema:name Department of Pathology, Institute of Tropical Medicine, Leading Graduate School Program, Nagasaki University, 852-8523, Nagasaki, Japan.
262 Department of Virology, Institute of Tropical Medicine, Leading Graduate School Program, Nagasaki University, 852-8523, Nagasaki, Japan.
263 rdf:type schema:Organization
264 https://www.grid.ac/institutes/grid.415689.7 schema:alternateName National Sagamihara Hospital
265 schema:name Clinical Research Center, National Hospital Organization Sagamihara Hospital, Sakuradai 18-1, Sagamihara, Kanagawa 228-8522, Japan.
266 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...