In vivo neuronal action potential recordings via three-dimensional microscale needle-electrode arrays View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-05

AUTHORS

Akifumi Fujishiro, Hidekazu Kaneko, Takahiro Kawashima, Makoto Ishida, Takeshi Kawano

ABSTRACT

Very fine needle-electrode arrays potentially offer both low invasiveness and high spatial resolution of electrophysiological neuronal recordings in vivo. Herein we report the penetrating and recording capabilities of silicon-growth-based three-dimensional microscale-diameter needle-electrodes arrays. The fabricated needles exhibit a circular-cone shape with a 3-μm-diameter tip and a 210-μm length. Due to the microscale diameter, our silicon needles are more flexible than other microfabricated silicon needles with larger diameters. Coating the microscale-needle-tip with platinum black results in an impedance of ~600 kΩ in saline with output/input signal amplitude ratios of more than 90% at 40 Hz-10 kHz. The needles can penetrate into the whisker barrel area of a rat's cerebral cortex, and the action potentials recorded from some neurons exhibit peak-to-peak amplitudes of ~300 μVpp. These results demonstrate the feasibility of in vivo neuronal action potential recordings with a microscale needle-electrode array fabricated using silicon growth technology. More... »

PAGES

4868

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep04868

DOI

http://dx.doi.org/10.1038/srep04868

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042635039

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24785307


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