Viability of Long-Term Gene Therapy in the Cochlea View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-04-22

AUTHORS

Patrick J. Atkinson, Andrew K. Wise, Brianna O. Flynn, Bryony A. Nayagam, Rachael T. Richardson

ABSTRACT

Gene therapy has been investigated as a way to introduce a variety of genes to treat neurological disorders. An important clinical consideration is its long-term effectiveness. This research aims to study the long-term expression and effectiveness of gene therapy in promoting spiral ganglion neuron survival after deafness. Adenoviral vectors modified to express brain derived neurotrophic factor or neurotrophin-3 were unilaterally injected into the guinea pig cochlea one week post ototoxic deafening. After six months, persistence of gene expression and significantly greater neuronal survival in neurotrophin-treated cochleae compared to the contralateral cochleae were observed. The long-term gene expression observed indicates that gene therapy is potentially viable; however the degeneration of the transduced cells as a result of the original ototoxic insult may limit clinical effectiveness. With further research aimed at transducing stable cochlear cells, gene therapy may be an efficacious way to introduce neurotrophins to promote neuronal survival after hearing loss. More... »

PAGES

4733

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep04733

DOI

http://dx.doi.org/10.1038/srep04733

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030294508

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24751795


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoviridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain-Derived Neurotrophic Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cochlea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deafness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Transfer Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Reporter", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Vectors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Growth Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurotrophin 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ of Corti", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spiral Ganglion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Swine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Otolaryngology, University of Melbourne, East Melbourne, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Bionics Institute, East Melbourne, Victoria, Australia", 
            "Department of Otolaryngology, University of Melbourne, East Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Atkinson", 
        "givenName": "Patrick J.", 
        "id": "sg:person.0722111220.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722111220.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Bionics, University of Melbourne, East Melbourne, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Bionics Institute, East Melbourne, Victoria, Australia", 
            "Department of Otolaryngology, University of Melbourne, East Melbourne, Victoria, Australia", 
            "Department of Medical Bionics, University of Melbourne, East Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wise", 
        "givenName": "Andrew K.", 
        "id": "sg:person.01036337620.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036337620.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bionics Institute, East Melbourne, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.431365.6", 
          "name": [
            "Bionics Institute, East Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Flynn", 
        "givenName": "Brianna O.", 
        "id": "sg:person.01016701420.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016701420.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Audiology and Speech Pathology, University of Melbourne, Parkville, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Bionics Institute, East Melbourne, Victoria, Australia", 
            "Department of Audiology and Speech Pathology, University of Melbourne, Parkville, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nayagam", 
        "givenName": "Bryony A.", 
        "id": "sg:person.01221410204.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221410204.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Bionics, University of Melbourne, East Melbourne, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Bionics Institute, East Melbourne, Victoria, Australia", 
            "Department of Otolaryngology, University of Melbourne, East Melbourne, Victoria, Australia", 
            "Department of Medical Bionics, University of Melbourne, East Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Richardson", 
        "givenName": "Rachael T.", 
        "id": "sg:person.012706275437.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012706275437.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10162-009-0170-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031788939", 
          "https://doi.org/10.1007/s10162-009-0170-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13311-011-0070-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029236966", 
          "https://doi.org/10.1007/s13311-011-0070-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003234529", 
          "https://doi.org/10.1038/nm1193"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-04-22", 
    "datePublishedReg": "2014-04-22", 
    "description": "Gene therapy has been investigated as a way to introduce a variety of genes to treat neurological disorders. An important clinical consideration is its long-term effectiveness. This research aims to study the long-term expression and effectiveness of gene therapy in promoting spiral ganglion neuron survival after deafness. Adenoviral vectors modified to express brain derived neurotrophic factor or neurotrophin-3 were unilaterally injected into the guinea pig cochlea one week post ototoxic deafening. After six months, persistence of gene expression and significantly greater neuronal survival in neurotrophin-treated cochleae compared to the contralateral cochleae were observed. The long-term gene expression observed indicates that gene therapy is potentially viable; however the degeneration of the transduced cells as a result of the original ototoxic insult may limit clinical effectiveness. With further research aimed at transducing stable cochlear cells, gene therapy may be an efficacious way to introduce neurotrophins to promote neuronal survival after hearing loss. ", 
    "genre": "article", 
    "id": "sg:pub.10.1038/srep04733", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6736657", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5136362", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "keywords": [
      "neuronal survival", 
      "spiral ganglion neuron survival", 
      "gene therapy", 
      "greater neuronal survival", 
      "important clinical consideration", 
      "long-term gene therapy", 
      "long-term effectiveness", 
      "contralateral cochlea", 
      "neurotrophic factor", 
      "neurotrophin-3", 
      "neuron survival", 
      "clinical effectiveness", 
      "ototoxic insult", 
      "cochlear cells", 
      "clinical considerations", 
      "neurological disorders", 
      "therapy", 
      "long-term expression", 
      "gene expression", 
      "adenoviral vector", 
      "cochlea", 
      "neurotrophins", 
      "survival", 
      "long-term gene expression", 
      "variety of genes", 
      "efficacious way", 
      "further research", 
      "expression", 
      "cells", 
      "ototoxic", 
      "degeneration", 
      "insult", 
      "brain", 
      "months", 
      "deafness", 
      "disorders", 
      "effectiveness", 
      "factors", 
      "viability", 
      "genes", 
      "persistence", 
      "loss", 
      "research", 
      "results", 
      "variety", 
      "consideration", 
      "vector", 
      "way", 
      "ganglion neuron survival", 
      "guinea pig cochlea one week post ototoxic", 
      "pig cochlea one week post ototoxic", 
      "cochlea one week post ototoxic", 
      "one week post ototoxic", 
      "week post ototoxic", 
      "post ototoxic", 
      "original ototoxic insult", 
      "stable cochlear cells"
    ], 
    "name": "Viability of Long-Term Gene Therapy in the Cochlea", 
    "pagination": "4733", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030294508"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep04733"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24751795"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep04733", 
      "https://app.dimensions.ai/details/publication/pub.1030294508"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_642.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/srep04733"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep04733'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep04733'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep04733'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep04733'


 

This table displays all metadata directly associated to this object as RDF triples.

250 TRIPLES      22 PREDICATES      106 URIs      95 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep04733 schema:about N013ecb1f767b4c058b76de33dfd64c8e
2 N341c27eb4cf947c1aa71692ea45aef8e
3 N3ec80755c3de46ab80fa6d95f69ba1b9
4 N446b8cf42de94937a4b8c90d7020a6a0
5 N5bfa901c5c154e6cb5bf6db6ee6ef937
6 N61e0a76328a444329c9b602bed4fe5bc
7 N6aa0e4b3fce1476c9540c22039aac7a9
8 N6e5dd36cd045402ebb906e411870a5b8
9 N75560448329a4acf9c2048cd4ec3b4af
10 N778c7cc26fbc4e3cb53604fe7a307801
11 N78b2241e6676455fb9a2c6d5e9e57dea
12 N879c1bf22c1a4322a8476051a6850027
13 N9e75d70cd05247409bb3b04366a4d24f
14 Nacfa9661d8014cb58afa5f67d46243c5
15 Naf87c26e363245ab8a0ec13d804ad693
16 Nb324ecde33314a4e89e64c1176dda8da
17 Nb4125243f2544f82a113725b61caa126
18 Ncd27b39bda774ee7b4e56c8f2b628dec
19 Nd61e693c57c5456ea9129457cfa4dcf3
20 Nd875c67c84204c989ed7bc4d1e07890b
21 anzsrc-for:11
22 anzsrc-for:1109
23 schema:author Nda7d8df5b6a04b829af918510e06705d
24 schema:citation sg:pub.10.1007/s10162-009-0170-2
25 sg:pub.10.1007/s13311-011-0070-0
26 sg:pub.10.1038/nm1193
27 schema:datePublished 2014-04-22
28 schema:datePublishedReg 2014-04-22
29 schema:description Gene therapy has been investigated as a way to introduce a variety of genes to treat neurological disorders. An important clinical consideration is its long-term effectiveness. This research aims to study the long-term expression and effectiveness of gene therapy in promoting spiral ganglion neuron survival after deafness. Adenoviral vectors modified to express brain derived neurotrophic factor or neurotrophin-3 were unilaterally injected into the guinea pig cochlea one week post ototoxic deafening. After six months, persistence of gene expression and significantly greater neuronal survival in neurotrophin-treated cochleae compared to the contralateral cochleae were observed. The long-term gene expression observed indicates that gene therapy is potentially viable; however the degeneration of the transduced cells as a result of the original ototoxic insult may limit clinical effectiveness. With further research aimed at transducing stable cochlear cells, gene therapy may be an efficacious way to introduce neurotrophins to promote neuronal survival after hearing loss.
30 schema:genre article
31 schema:inLanguage en
32 schema:isAccessibleForFree true
33 schema:isPartOf N1d1bf7e3419e4c9885ad0fb4adace29a
34 N5f2b11dab94244108920e229a5d5d5b1
35 sg:journal.1045337
36 schema:keywords adenoviral vector
37 brain
38 cells
39 clinical considerations
40 clinical effectiveness
41 cochlea
42 cochlea one week post ototoxic
43 cochlear cells
44 consideration
45 contralateral cochlea
46 deafness
47 degeneration
48 disorders
49 effectiveness
50 efficacious way
51 expression
52 factors
53 further research
54 ganglion neuron survival
55 gene expression
56 gene therapy
57 genes
58 greater neuronal survival
59 guinea pig cochlea one week post ototoxic
60 important clinical consideration
61 insult
62 long-term effectiveness
63 long-term expression
64 long-term gene expression
65 long-term gene therapy
66 loss
67 months
68 neurological disorders
69 neuron survival
70 neuronal survival
71 neurotrophic factor
72 neurotrophin-3
73 neurotrophins
74 one week post ototoxic
75 original ototoxic insult
76 ototoxic
77 ototoxic insult
78 persistence
79 pig cochlea one week post ototoxic
80 post ototoxic
81 research
82 results
83 spiral ganglion neuron survival
84 stable cochlear cells
85 survival
86 therapy
87 variety
88 variety of genes
89 vector
90 viability
91 way
92 week post ototoxic
93 schema:name Viability of Long-Term Gene Therapy in the Cochlea
94 schema:pagination 4733
95 schema:productId N177c2b7867fa488baf0a2b21c0bb5177
96 N7d716f68baf24a1e9b27382e2108be25
97 N998c56dee36742afbeb80934dbab2030
98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030294508
99 https://doi.org/10.1038/srep04733
100 schema:sdDatePublished 2021-12-01T19:32
101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
102 schema:sdPublisher Ne7717a24e8cb41cf8c97e5a2158e8251
103 schema:url https://doi.org/10.1038/srep04733
104 sgo:license sg:explorer/license/
105 sgo:sdDataset articles
106 rdf:type schema:ScholarlyArticle
107 N013ecb1f767b4c058b76de33dfd64c8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Adenoviridae
109 rdf:type schema:DefinedTerm
110 N177c2b7867fa488baf0a2b21c0bb5177 schema:name dimensions_id
111 schema:value pub.1030294508
112 rdf:type schema:PropertyValue
113 N1d1bf7e3419e4c9885ad0fb4adace29a schema:volumeNumber 4
114 rdf:type schema:PublicationVolume
115 N1d645c14476e42779ba06615c1fb5e0e rdf:first sg:person.01016701420.44
116 rdf:rest Nbb3e0f2d36634c19b4c518c6dfb10226
117 N341c27eb4cf947c1aa71692ea45aef8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Time Factors
119 rdf:type schema:DefinedTerm
120 N3ec80755c3de46ab80fa6d95f69ba1b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Spiral Ganglion
122 rdf:type schema:DefinedTerm
123 N446b8cf42de94937a4b8c90d7020a6a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Deafness
125 rdf:type schema:DefinedTerm
126 N5bfa901c5c154e6cb5bf6db6ee6ef937 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Neurotrophin 3
128 rdf:type schema:DefinedTerm
129 N5f2b11dab94244108920e229a5d5d5b1 schema:issueNumber 1
130 rdf:type schema:PublicationIssue
131 N61e0a76328a444329c9b602bed4fe5bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Female
133 rdf:type schema:DefinedTerm
134 N6aa0e4b3fce1476c9540c22039aac7a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Genes, Reporter
136 rdf:type schema:DefinedTerm
137 N6e5dd36cd045402ebb906e411870a5b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Disease Models, Animal
139 rdf:type schema:DefinedTerm
140 N75560448329a4acf9c2048cd4ec3b4af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Male
142 rdf:type schema:DefinedTerm
143 N778c7cc26fbc4e3cb53604fe7a307801 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Gene Expression
145 rdf:type schema:DefinedTerm
146 N78b2241e6676455fb9a2c6d5e9e57dea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Cochlea
148 rdf:type schema:DefinedTerm
149 N7d716f68baf24a1e9b27382e2108be25 schema:name pubmed_id
150 schema:value 24751795
151 rdf:type schema:PropertyValue
152 N879c1bf22c1a4322a8476051a6850027 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Cell Survival
154 rdf:type schema:DefinedTerm
155 N998c56dee36742afbeb80934dbab2030 schema:name doi
156 schema:value 10.1038/srep04733
157 rdf:type schema:PropertyValue
158 N9e75d70cd05247409bb3b04366a4d24f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Gene Transfer Techniques
160 rdf:type schema:DefinedTerm
161 Nacfa9661d8014cb58afa5f67d46243c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Genetic Vectors
163 rdf:type schema:DefinedTerm
164 Naf87c26e363245ab8a0ec13d804ad693 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Organ of Corti
166 rdf:type schema:DefinedTerm
167 Nb324ecde33314a4e89e64c1176dda8da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Animals
169 rdf:type schema:DefinedTerm
170 Nb4125243f2544f82a113725b61caa126 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Nerve Growth Factors
172 rdf:type schema:DefinedTerm
173 Nbb3e0f2d36634c19b4c518c6dfb10226 rdf:first sg:person.01221410204.05
174 rdf:rest Nf45fce123733495da7f3775ab3789669
175 Ncd27b39bda774ee7b4e56c8f2b628dec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Genetic Therapy
177 rdf:type schema:DefinedTerm
178 Nd61e693c57c5456ea9129457cfa4dcf3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Swine
180 rdf:type schema:DefinedTerm
181 Nd875c67c84204c989ed7bc4d1e07890b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Brain-Derived Neurotrophic Factor
183 rdf:type schema:DefinedTerm
184 Nda7d8df5b6a04b829af918510e06705d rdf:first sg:person.0722111220.23
185 rdf:rest Ne7d9090839cc44168b23c066e1a67e66
186 Ne7717a24e8cb41cf8c97e5a2158e8251 schema:name Springer Nature - SN SciGraph project
187 rdf:type schema:Organization
188 Ne7d9090839cc44168b23c066e1a67e66 rdf:first sg:person.01036337620.95
189 rdf:rest N1d645c14476e42779ba06615c1fb5e0e
190 Nf45fce123733495da7f3775ab3789669 rdf:first sg:person.012706275437.15
191 rdf:rest rdf:nil
192 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
193 schema:name Medical and Health Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
196 schema:name Neurosciences
197 rdf:type schema:DefinedTerm
198 sg:grant.5136362 http://pending.schema.org/fundedItem sg:pub.10.1038/srep04733
199 rdf:type schema:MonetaryGrant
200 sg:grant.6736657 http://pending.schema.org/fundedItem sg:pub.10.1038/srep04733
201 rdf:type schema:MonetaryGrant
202 sg:journal.1045337 schema:issn 2045-2322
203 schema:name Scientific Reports
204 schema:publisher Springer Nature
205 rdf:type schema:Periodical
206 sg:person.01016701420.44 schema:affiliation grid-institutes:grid.431365.6
207 schema:familyName Flynn
208 schema:givenName Brianna O.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016701420.44
210 rdf:type schema:Person
211 sg:person.01036337620.95 schema:affiliation grid-institutes:grid.1008.9
212 schema:familyName Wise
213 schema:givenName Andrew K.
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036337620.95
215 rdf:type schema:Person
216 sg:person.01221410204.05 schema:affiliation grid-institutes:grid.1008.9
217 schema:familyName Nayagam
218 schema:givenName Bryony A.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221410204.05
220 rdf:type schema:Person
221 sg:person.012706275437.15 schema:affiliation grid-institutes:grid.1008.9
222 schema:familyName Richardson
223 schema:givenName Rachael T.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012706275437.15
225 rdf:type schema:Person
226 sg:person.0722111220.23 schema:affiliation grid-institutes:grid.1008.9
227 schema:familyName Atkinson
228 schema:givenName Patrick J.
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722111220.23
230 rdf:type schema:Person
231 sg:pub.10.1007/s10162-009-0170-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031788939
232 https://doi.org/10.1007/s10162-009-0170-2
233 rdf:type schema:CreativeWork
234 sg:pub.10.1007/s13311-011-0070-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029236966
235 https://doi.org/10.1007/s13311-011-0070-0
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nm1193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003234529
238 https://doi.org/10.1038/nm1193
239 rdf:type schema:CreativeWork
240 grid-institutes:grid.1008.9 schema:alternateName Department of Audiology and Speech Pathology, University of Melbourne, Parkville, Victoria, Australia
241 Department of Medical Bionics, University of Melbourne, East Melbourne, Victoria, Australia
242 Department of Otolaryngology, University of Melbourne, East Melbourne, Victoria, Australia
243 schema:name Bionics Institute, East Melbourne, Victoria, Australia
244 Department of Audiology and Speech Pathology, University of Melbourne, Parkville, Victoria, Australia
245 Department of Medical Bionics, University of Melbourne, East Melbourne, Victoria, Australia
246 Department of Otolaryngology, University of Melbourne, East Melbourne, Victoria, Australia
247 rdf:type schema:Organization
248 grid-institutes:grid.431365.6 schema:alternateName Bionics Institute, East Melbourne, Victoria, Australia
249 schema:name Bionics Institute, East Melbourne, Victoria, Australia
250 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...