Limited geographic distribution of the novel cyclovirus CyCV-VN View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-05

AUTHORS

Van Tan Le, Menno D de Jong, Van Kinh Nguyen, Vu Trung Nguyen, Walter Taylor, Heiman F L Wertheim, Arie van der Ende, Lia van der Hoek, Marta Canuti, Martin Crusat, Soeng Sona, Hanh Uyen Nguyen, Abhishek Giri, Thi Thuy Chinh Bkrong Nguyen, Dang Trung Nghia Ho, Jeremy Farrar, Juliet E Bryant, Tinh Hien Tran, Van Vinh Chau Nguyen, H Rogier van Doorn

ABSTRACT

A novel cyclovirus, CyCV-VN, was recently identified in cerebrospinal fluid (CSF) from patients with central nervous system (CNS) infections in central and southern Vietnam. To explore the geographic distribution of this novel virus, more than 600 CSF specimens from patients with suspected CNS infections in northern Vietnam, Cambodia, Nepal and The Netherlands were screened for the presence of CyCV-VN but all were negative. Sequence comparison and phylogenetic analysis between CyCV-VN and another novel cyclovirus recently identified in CSF from Malawian patients indicated that these represent distinct cycloviral species, albeit phylogenetically closely related. The data suggest that CyCV-VN has a limited geographic distribution within southern and central Vietnam. Further research is needed to determine the global distribution and diversity of cycloviruses and importantly their possible association with human disease. More... »

PAGES

3967

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep03967

DOI

http://dx.doi.org/10.1038/srep03967

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009318488

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24495921


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347 schema:name 1] National Hospital for Tropical Diseases, Hanoi, Vietnam [2] Hanoi Medical University, Hanoi, Vietnam.
348 rdf:type schema:Organization
349 https://www.grid.ac/institutes/grid.417187.c schema:alternateName Patan Hospital
350 schema:name Oxford University Clinical Research Unit, Patan Hospital, Kathmandu, Nepal.
351 rdf:type schema:Organization
352 https://www.grid.ac/institutes/grid.459332.a schema:alternateName Angkor Hospital for Children
353 schema:name Angkor Hospital for Children, Siem Reap, Kingdom of Cambodia.
354 rdf:type schema:Organization
 




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