The relevance and applicability of oocyst prevalence as a read-out for mosquito feeding assays View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Will J. R. Stone, Maarten Eldering, Geert-Jan van Gemert, Kjerstin H. W. Lanke, Lynn Grignard, Marga G. van de Vegte-Bolmer, Rianne Siebelink-Stoter, Wouter Graumans, Will F. G. Roeffen, Chris J. Drakeley, Robert W. Sauerwein, Teun Bousema

ABSTRACT

Mosquito feeding assays are important in evaluations of malaria transmission-reducing interventions. The proportion of mosquitoes with midgut oocysts is commonly used as an outcome measure, but in natural low intensity infections the effect of oocyst non-rupture on mosquito infectivity is unclear. By identifying ruptured as well as intact oocysts, we show that in low intensity P. falciparum infections i) 66.7-96.7% of infected mosquitoes experienced oocyst rupture between 11-21 days post-infection, ii) oocyst rupture led invariably to sporozoite release, iii) oocyst rupture led to salivary gland infections in 97.8% of mosquitoes, and iv) 1250 (IQR 313-2400) salivary gland sporozoites were found per ruptured oocyst. These data show that infectivity can be predicted with reasonable certainty from oocyst prevalence in low intensity infections. High throughput methods for detecting infection in whole mosquitoes showed that 18s PCR but not circumsporozoite ELISA gave a reliable approximation of mosquito infection rates on day 7 post-infection. More... »

PAGES

3418

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep03418

DOI

http://dx.doi.org/10.1038/srep03418

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026544344

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24301557


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep03418'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep03418'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep03418'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep03418'


 

This table displays all metadata directly associated to this object as RDF triples.

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