HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Kotaro Sakata, Mitsuko Hara, Takaho Terada, Noriyuki Watanabe, Daisuke Takaya, So-ichi Yaguchi, Takehisa Matsumoto, Tomokazu Matsuura, Mikako Shirouzu, Shigeyuki Yokoyama, Tokio Yamaguchi, Keiji Miyazawa, Hideki Aizaki, Tetsuro Suzuki, Takaji Wakita, Masaya Imoto, Soichi Kojima

ABSTRACT

Viruses sometimes mimic host proteins and hijack the host cell machinery. Hepatitis C virus (HCV) causes liver fibrosis, a process largely mediated by the overexpression of transforming growth factor (TGF)-β and collagen, although the precise underlying mechanism is unknown. Here, we report that HCV non-structural protein 3 (NS3) protease affects the antigenicity and bioactivity of TGF-β2 in (CAGA)9-Luc CCL64 cells and in human hepatic cell lines via binding to TGF-β type I receptor (TβRI). Tumor necrosis factor (TNF)-α facilitates this mechanism by increasing the colocalization of TβRI with NS3 protease on the surface of HCV-infected cells. An anti-NS3 antibody against computationally predicted binding sites for TβRI blocked the TGF-β mimetic activities of NS3 in vitro and attenuated liver fibrosis in HCV-infected chimeric mice. These data suggest that HCV NS3 protease mimics TGF-β2 and functions, at least in part, via directly binding to and activating TβRI, thereby enhancing liver fibrosis. More... »

PAGES

3243

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep03243

DOI

http://dx.doi.org/10.1038/srep03243

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028175937

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24263861


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