Kinetic Evidence of an Apparent Negative Activation Enthalpy in an Organocatalytic Process View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-08-30

AUTHORS

Xiao Han, Richmond Lee, Tao Chen, Jie Luo, Yixin Lu, Kuo-Wei Huang

ABSTRACT

A combined kinetic and computational study on our tryptophan-based bifunctional thiourea catalyzed asymmetric Mannich reactions reveals an apparent negative activation enthalpy. The formation of the pre-transition state complex has been unambiguously confirmed and these observations provide an experimental support for the formation of multiple hydrogen bonding network between the substrates and the catalyst. Such interactions allow the creation of a binding cavity, a key factor to install high enantioselectivity. More... »

PAGES

2557

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep02557

DOI

http://dx.doi.org/10.1038/srep02557

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035252180

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23990028


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