Common dysfunctional variants in ABCG2 are a major cause of early-onset gout View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-06-18

AUTHORS

Hirotaka Matsuo, Kimiyoshi Ichida, Tappei Takada, Akiyoshi Nakayama, Hiroshi Nakashima, Takahiro Nakamura, Yusuke Kawamura, Yuzo Takada, Ken Yamamoto, Hiroki Inoue, Yuji Oikawa, Mariko Naito, Asahi Hishida, Kenji Wakai, Chisa Okada, Seiko Shimizu, Masayuki Sakiyama, Toshinori Chiba, Hiraku Ogata, Kazuki Niwa, Makoto Hosoyamada, Atsuyoshi Mori, Nobuyuki Hamajima, Hiroshi Suzuki, Yoshikatsu Kanai, Yutaka Sakurai, Tatsuo Hosoya, Toru Shimizu, Nariyoshi Shinomiya

ABSTRACT

Gout is a common disease which mostly occurs after middle age, but more people nowadays develop it before the age of thirty. We investigated whether common dysfunction of ABCG2, a high-capacity urate transporter which regulates serum uric acid levels, causes early-onset gout. 705 Japanese male gout cases with onset age data and 1,887 male controls were genotyped and the ABCG2 functions which are estimated by its genotype combination were determined. The onset age was 6.5 years earlier with severe ABCG2 dysfunction than with normal ABCG2 function (P = 6.14 × 10−3). Patients with mild to severe ABCG2 dysfunction accounted for 88.2% of early-onset cases (twenties or younger). Severe ABCG2 dysfunction particularly increased the risk of early-onset gout (odds ratio 22.2, P = 4.66 × 10−6). Our finding that common dysfunction of ABCG2 is a major cause of early-onset gout will serve to improve earlier prevention and therapy for high-risk individuals. More... »

PAGES

2014

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

3

Author Affiliations

  • Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, 359-8513, Saitama, Tokorozawa, Japan
  • Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, 3-19-18 Shinbashi, 105-8471, Tokyo, Minato-ku, Japan
  • Department of Pharmacy, the University of Tokyo Hospital, Faculty of Medicine, the University of Tokyo, 7-3-1 Hongo, 113-8655, Tokyo, Bunkyo-ku, Japan
  • Medical Group, Headquarters, Iwo-to Air Base Group, Japan Air Self-Defense Force, Iwo-to, 100-2100, Ogasawarax, Ogasawara, Japan
  • Department of Preventive Medicine and Public Health, National Defense Medical College, 3-2 Namiki, 359-8513, Saitama, Tokorozawa, Japan
  • Laboratory for Statistical Analysis, Center for Genomic Medicine, Institute of Physical and Chemical Research (RIKEN), 4-6-1 Shirokanedai, 108-8639, Minato-ku, Tokyo, Japan
  • Laboratory for Biofunctions, the Central Research Institute, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan
  • Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, 812-8582, Higashi-ku, Fukuoka, Japan
  • Department of Biology, Faculty of Science, Toho University, 2-2-1 Miyama, 274-8510, Funabashi, Chiba, Japan
  • Department of Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, 466-8550, Showa-ku, Nagoya, Aichi, Japan
  • Department of Human Physiology and Pathology, Teikyo University School of Pharmaceutical Sciences, 2-11-1 Kaga, 173-8605, Itabashi-ku, Tokyo, Japan
  • Seirei Preventive Health Care Center, 3453 Mikatahara-cho, 433-8558, Kita-ku, Hamamatsu, Shizuoka, Japan
  • Department of Healthcare Administration, Young Leaders' Program, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, 466-8550, Showa-ku, Nagoya, Aichi, Japan
  • Division of Bio-system Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, 565-0871, Osaka, Suita, Japan
  • Midorigaoka Hospital, 3-13-1 Makami-cho, 569-1121, Takatsuki, Osaka, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep02014

    DOI

    http://dx.doi.org/10.1038/srep02014

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006103959

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23774753


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