Common dysfunctional variants in ABCG2 are a major cause of early-onset gout View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Hirotaka Matsuo, Kimiyoshi Ichida, Tappei Takada, Akiyoshi Nakayama, Hiroshi Nakashima, Takahiro Nakamura, Yusuke Kawamura, Yuzo Takada, Ken Yamamoto, Hiroki Inoue, Yuji Oikawa, Mariko Naito, Asahi Hishida, Kenji Wakai, Chisa Okada, Seiko Shimizu, Masayuki Sakiyama, Toshinori Chiba, Hiraku Ogata, Kazuki Niwa, Makoto Hosoyamada, Atsuyoshi Mori, Nobuyuki Hamajima, Hiroshi Suzuki, Yoshikatsu Kanai, Yutaka Sakurai, Tatsuo Hosoya, Toru Shimizu, Nariyoshi Shinomiya

ABSTRACT

Gout is a common disease which mostly occurs after middle age, but more people nowadays develop it before the age of thirty. We investigated whether common dysfunction of ABCG2, a high-capacity urate transporter which regulates serum uric acid levels, causes early-onset gout. 705 Japanese male gout cases with onset age data and 1,887 male controls were genotyped, and the ABCG2 functions which are estimated by its genotype combination were determined. The onset age was 6.5 years earlier with severe ABCG2 dysfunction than with normal ABCG2 function (P = 6.14 × 10(-3)). Patients with mild to severe ABCG2 dysfunction accounted for 88.2% of early-onset cases (twenties or younger). Severe ABCG2 dysfunction particularly increased the risk of early-onset gout (odds ratio 22.2, P = 4.66 × 10(-6)). Our finding that common dysfunction of ABCG2 is a major cause of early-onset gout will serve to improve earlier prevention and therapy for high-risk individuals. More... »

PAGES

2014

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep02014

DOI

http://dx.doi.org/10.1038/srep02014

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006103959

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23774753


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