DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12-11

AUTHORS

Xiangmin Lin, Travis J. Cook, Cyrus P. Zabetian, James B. Leverenz, Elaine R. Peskind, Shu-Ching Hu, Kevin C. Cain, Catherine Pan, John Scott Edgar, David R. Goodlett, Brad A. Racette, Harvey Checkoway, Thomas J. Montine, Min Shi, Jing Zhang

ABSTRACT

DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death and synucleinopathies, including Parkinson disease. Previous studies have demonstrated that total DJ-1 levels decrease in the cerebrospinal fluid, but do not change significantly in human plasma from patients with Parkinson disease when compared with controls. In this study, we measured total DJ-1 and its isoforms in whole blood of patients with Parkinson disease at various stages, Alzheimer disease and healthy controls to identify potential peripheral biomarkers of PD. In an initial discovery study of 119 subjects, 7 DJ-1 isoforms were reliably detected and blood levels of those with 4-hydroxy-2-nonenal modifications were discovered to be altered in late-stage Parkinson disease. This result was further confirmed in a validation study of another 114 participants, suggesting that, unlike total DJ-1 levels, post-translationally modified isoforms of DJ-1 from whole blood are candidate biomarkers of late-stage Parkinson disease. More... »

PAGES

954

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep00954

DOI

http://dx.doi.org/10.1038/srep00954

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024528362

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23233873


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alzheimer Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophoresis, Gel, Two-Dimensional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parkinson Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Deglycase DJ-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Isoforms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Processing, Post-Translational", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "School of Life Sciences, Fujian Agricultural and Forestry University, 35002, Fuzhou, People's Republic of China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA", 
            "School of Life Sciences, Fujian Agricultural and Forestry University, 35002, Fuzhou, People's Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Xiangmin", 
        "id": "sg:person.0651666711.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651666711.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Environmental & Occupational Health Sciences, University of Washington School of Public Health, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Environmental & Occupational Health Sciences, University of Washington School of Public Health, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cook", 
        "givenName": "Travis J.", 
        "id": "sg:person.0634514014.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634514014.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Parkinson's Disease Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA", 
            "Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA", 
            "Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zabetian", 
        "givenName": "Cyrus P.", 
        "id": "sg:person.01154165643.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154165643.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mental Illness Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.413919.7", 
          "name": [
            "Parkinson's Disease Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA", 
            "Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA", 
            "Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA", 
            "Mental Illness Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leverenz", 
        "givenName": "James B.", 
        "id": "sg:person.0775430702.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775430702.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Mental Illness Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA", 
            "Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peskind", 
        "givenName": "Elaine R.", 
        "id": "sg:person.0717014774.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717014774.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Shu-Ching", 
        "id": "sg:person.01065171014.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065171014.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biostatistics, University of Washington School of Public Health, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Biostatistics, University of Washington School of Public Health, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cain", 
        "givenName": "Kevin C.", 
        "id": "sg:person.0623760204.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623760204.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pan", 
        "givenName": "Catherine", 
        "id": "sg:person.01201417414.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201417414.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicinal Chemistry, University of Washington School of Pharmacy, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Medicinal Chemistry, University of Washington School of Pharmacy, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Edgar", 
        "givenName": "John Scott", 
        "id": "sg:person.01117436013.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117436013.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicinal Chemistry, University of Washington School of Pharmacy, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Medicinal Chemistry, University of Washington School of Pharmacy, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goodlett", 
        "givenName": "David R.", 
        "id": "sg:person.01044126157.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044126157.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Racette", 
        "givenName": "Brad A.", 
        "id": "sg:person.01357504135.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357504135.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Environmental & Occupational Health Sciences, University of Washington School of Public Health, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Environmental & Occupational Health Sciences, University of Washington School of Public Health, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Checkoway", 
        "givenName": "Harvey", 
        "id": "sg:person.01214305720.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214305720.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Montine", 
        "givenName": "Thomas J.", 
        "id": "sg:person.0714314167.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714314167.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Min", 
        "id": "sg:person.0610440123.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610440123.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jing", 
        "id": "sg:person.013221630453.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013221630453.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nbt1046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040698216", 
          "https://doi.org/10.1038/nbt1046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1039/c0pp00369g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002829296", 
          "https://doi.org/10.1039/c0pp00369g"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2009.353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008023249", 
          "https://doi.org/10.1038/nnano.2009.353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10072-003-0108-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021024460", 
          "https://doi.org/10.1007/s10072-003-0108-0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12-11", 
    "datePublishedReg": "2012-12-11", 
    "description": "DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death and synucleinopathies, including Parkinson disease. Previous studies have demonstrated that total DJ-1 levels decrease in the cerebrospinal fluid, but do not change significantly in human plasma from patients with Parkinson disease when compared with controls. In this study, we measured total DJ-1 and its isoforms in whole blood of patients with Parkinson disease at various stages, Alzheimer disease and healthy controls to identify potential peripheral biomarkers of PD. In an initial discovery study of 119 subjects, 7 DJ-1 isoforms were reliably detected and blood levels of those with 4-hydroxy-2-nonenal modifications were discovered to be altered in late-stage Parkinson disease. This result was further confirmed in a validation study of another 114 participants, suggesting that, unlike total DJ-1 levels, post-translationally modified isoforms of DJ-1 from whole blood are candidate biomarkers of late-stage Parkinson disease.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/srep00954", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2439101", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2504011", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2504119", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2561936", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2401335", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2441118", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2448527", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439942", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2562501", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2683569", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2617361", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2447823", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "keywords": [
      "late-stage Parkinson's disease", 
      "DJ-1 isoforms", 
      "Parkinson's disease", 
      "DJ-1 levels", 
      "whole blood", 
      "DJ-1", 
      "total DJ-1", 
      "initial discovery study", 
      "potential peripheral biomarker", 
      "peripheral biomarkers", 
      "blood levels", 
      "healthy controls", 
      "cerebrospinal fluid", 
      "candidate biomarkers", 
      "Alzheimer's disease", 
      "potential biomarkers", 
      "disease", 
      "oxidative stress", 
      "blood", 
      "biomarkers", 
      "patients", 
      "cell death", 
      "validation study", 
      "discovery studies", 
      "human plasma", 
      "isoforms", 
      "previous studies", 
      "synucleinopathies", 
      "multifunctional protein", 
      "levels", 
      "study", 
      "important role", 
      "death", 
      "control", 
      "subjects", 
      "participants", 
      "plasma", 
      "protein", 
      "role", 
      "fluid", 
      "stage", 
      "stress", 
      "Pd", 
      "results", 
      "modification"
    ], 
    "name": "DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease", 
    "pagination": "954", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024528362"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep00954"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23233873"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep00954", 
      "https://app.dimensions.ai/details/publication/pub.1024528362"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T20:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_566.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/srep00954"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep00954'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep00954'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep00954'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep00954'


 

This table displays all metadata directly associated to this object as RDF triples.

329 TRIPLES      21 PREDICATES      89 URIs      77 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep00954 schema:about N007bcff176174501bf6312aed6e18aeb
2 N2120cdeb4a89470c9fe24ce218fa897e
3 N2dce7ba0effa4c9288ddad51a014d7f5
4 N3217bb5d669944df8793dbed7dfc5979
5 N61a2c0ab25614b9ab391b00038024cfb
6 N7efd28850a4e4ebdb5b7dbaca626cc35
7 N9773652c649340199d9ed3d8c16c34ef
8 Nb3d2cec9c8ce4c70ae144cc3bce3ad5c
9 Nc2a00930d47541a292fee4381ef0d354
10 Ncaa63e085aa44c77aa82a78289b0ab30
11 Ncd8c6a5560bf4cb5a5c3659190631ba5
12 Ncdba0782db7b496abc68807ce224719a
13 Nd89040a1c84b4e6bb6cb10b96ea9bffd
14 Ndabbdb29501f410b950f7b9f51ff2790
15 Nf5f015cc52c44b83b2d0c131224e5030
16 anzsrc-for:11
17 anzsrc-for:1109
18 schema:author Nbd44b318da674a0baba155ff8355d5c4
19 schema:citation sg:pub.10.1007/s10072-003-0108-0
20 sg:pub.10.1038/nbt1046
21 sg:pub.10.1038/nnano.2009.353
22 sg:pub.10.1039/c0pp00369g
23 schema:datePublished 2012-12-11
24 schema:datePublishedReg 2012-12-11
25 schema:description DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death and synucleinopathies, including Parkinson disease. Previous studies have demonstrated that total DJ-1 levels decrease in the cerebrospinal fluid, but do not change significantly in human plasma from patients with Parkinson disease when compared with controls. In this study, we measured total DJ-1 and its isoforms in whole blood of patients with Parkinson disease at various stages, Alzheimer disease and healthy controls to identify potential peripheral biomarkers of PD. In an initial discovery study of 119 subjects, 7 DJ-1 isoforms were reliably detected and blood levels of those with 4-hydroxy-2-nonenal modifications were discovered to be altered in late-stage Parkinson disease. This result was further confirmed in a validation study of another 114 participants, suggesting that, unlike total DJ-1 levels, post-translationally modified isoforms of DJ-1 from whole blood are candidate biomarkers of late-stage Parkinson disease.
26 schema:genre article
27 schema:isAccessibleForFree true
28 schema:isPartOf N7a290f4e7eea4d528dba934bb5938f35
29 Nfdfc35e6d2a64d3d83e6d170702c8dee
30 sg:journal.1045337
31 schema:keywords Alzheimer's disease
32 DJ-1
33 DJ-1 isoforms
34 DJ-1 levels
35 Parkinson's disease
36 Pd
37 biomarkers
38 blood
39 blood levels
40 candidate biomarkers
41 cell death
42 cerebrospinal fluid
43 control
44 death
45 discovery studies
46 disease
47 fluid
48 healthy controls
49 human plasma
50 important role
51 initial discovery study
52 isoforms
53 late-stage Parkinson's disease
54 levels
55 modification
56 multifunctional protein
57 oxidative stress
58 participants
59 patients
60 peripheral biomarkers
61 plasma
62 potential biomarkers
63 potential peripheral biomarker
64 previous studies
65 protein
66 results
67 role
68 stage
69 stress
70 study
71 subjects
72 synucleinopathies
73 total DJ-1
74 validation study
75 whole blood
76 schema:name DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease
77 schema:pagination 954
78 schema:productId N0703539182e44547966f05d9fd54e6ea
79 N1d2506705ef64dec8b5bdfb943b41c14
80 Nd5934c637dc84d6e82ca11a2cf0ddbe3
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024528362
82 https://doi.org/10.1038/srep00954
83 schema:sdDatePublished 2022-11-24T20:56
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher N3543dff4bfad48fda2a33696f3c4c87f
86 schema:url https://doi.org/10.1038/srep00954
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N007bcff176174501bf6312aed6e18aeb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Intracellular Signaling Peptides and Proteins
92 rdf:type schema:DefinedTerm
93 N0340a69cd9ad426887d6ab32c6ef1b3e rdf:first sg:person.0610440123.04
94 rdf:rest Ndad02be4740a491698c844741e156ebf
95 N0703539182e44547966f05d9fd54e6ea schema:name pubmed_id
96 schema:value 23233873
97 rdf:type schema:PropertyValue
98 N101306b4161d421d9700f6ab1db0fbf8 rdf:first sg:person.0717014774.70
99 rdf:rest N6a5889c0b4f549aeb2520b803b9a1fc5
100 N1040f08ec16a47f4a9ffd3c1a947f1e8 rdf:first sg:person.0714314167.12
101 rdf:rest N0340a69cd9ad426887d6ab32c6ef1b3e
102 N13ead13f9088426695ca2c38a3f6e9f8 rdf:first sg:person.01201417414.17
103 rdf:rest N435cec0f813e41bb88ec68dfb4f50348
104 N1b9cf1f22bee4b27aec78774e1790530 rdf:first sg:person.0775430702.19
105 rdf:rest N101306b4161d421d9700f6ab1db0fbf8
106 N1d2506705ef64dec8b5bdfb943b41c14 schema:name doi
107 schema:value 10.1038/srep00954
108 rdf:type schema:PropertyValue
109 N2120cdeb4a89470c9fe24ce218fa897e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Female
111 rdf:type schema:DefinedTerm
112 N2dce7ba0effa4c9288ddad51a014d7f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Male
114 rdf:type schema:DefinedTerm
115 N3217bb5d669944df8793dbed7dfc5979 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Aged
117 rdf:type schema:DefinedTerm
118 N3543dff4bfad48fda2a33696f3c4c87f schema:name Springer Nature - SN SciGraph project
119 rdf:type schema:Organization
120 N415d6925b8994252b303cd4f8b6aeecc rdf:first sg:person.0634514014.46
121 rdf:rest Ndeef663b1ff74b46ac377a8160e919cd
122 N435cec0f813e41bb88ec68dfb4f50348 rdf:first sg:person.01117436013.50
123 rdf:rest Na3227e23d9a04cf19dc867c1df69767a
124 N4c61b1a9de1a46b4a6683112a7e28d00 rdf:first sg:person.0623760204.30
125 rdf:rest N13ead13f9088426695ca2c38a3f6e9f8
126 N61a2c0ab25614b9ab391b00038024cfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Electrophoresis, Gel, Two-Dimensional
128 rdf:type schema:DefinedTerm
129 N6a5889c0b4f549aeb2520b803b9a1fc5 rdf:first sg:person.01065171014.45
130 rdf:rest N4c61b1a9de1a46b4a6683112a7e28d00
131 N7a290f4e7eea4d528dba934bb5938f35 schema:volumeNumber 2
132 rdf:type schema:PublicationVolume
133 N7efd28850a4e4ebdb5b7dbaca626cc35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Protein Isoforms
135 rdf:type schema:DefinedTerm
136 N91718f8954674ba7a82e2d2e287d25c7 rdf:first sg:person.01214305720.20
137 rdf:rest N1040f08ec16a47f4a9ffd3c1a947f1e8
138 N9773652c649340199d9ed3d8c16c34ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Middle Aged
140 rdf:type schema:DefinedTerm
141 Na3227e23d9a04cf19dc867c1df69767a rdf:first sg:person.01044126157.13
142 rdf:rest Nf7b7e53dff3b4ba9800803f2a67d0ba8
143 Nb3d2cec9c8ce4c70ae144cc3bce3ad5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Humans
145 rdf:type schema:DefinedTerm
146 Nbd44b318da674a0baba155ff8355d5c4 rdf:first sg:person.0651666711.76
147 rdf:rest N415d6925b8994252b303cd4f8b6aeecc
148 Nc2a00930d47541a292fee4381ef0d354 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Parkinson Disease
150 rdf:type schema:DefinedTerm
151 Ncaa63e085aa44c77aa82a78289b0ab30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Protein Processing, Post-Translational
153 rdf:type schema:DefinedTerm
154 Ncd8c6a5560bf4cb5a5c3659190631ba5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Biomarkers
156 rdf:type schema:DefinedTerm
157 Ncdba0782db7b496abc68807ce224719a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Protein Deglycase DJ-1
159 rdf:type schema:DefinedTerm
160 Nd5934c637dc84d6e82ca11a2cf0ddbe3 schema:name dimensions_id
161 schema:value pub.1024528362
162 rdf:type schema:PropertyValue
163 Nd89040a1c84b4e6bb6cb10b96ea9bffd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Blotting, Western
165 rdf:type schema:DefinedTerm
166 Ndabbdb29501f410b950f7b9f51ff2790 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Alzheimer Disease
168 rdf:type schema:DefinedTerm
169 Ndad02be4740a491698c844741e156ebf rdf:first sg:person.013221630453.07
170 rdf:rest rdf:nil
171 Ndeef663b1ff74b46ac377a8160e919cd rdf:first sg:person.01154165643.22
172 rdf:rest N1b9cf1f22bee4b27aec78774e1790530
173 Nf5f015cc52c44b83b2d0c131224e5030 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Oncogene Proteins
175 rdf:type schema:DefinedTerm
176 Nf7b7e53dff3b4ba9800803f2a67d0ba8 rdf:first sg:person.01357504135.93
177 rdf:rest N91718f8954674ba7a82e2d2e287d25c7
178 Nfdfc35e6d2a64d3d83e6d170702c8dee schema:issueNumber 1
179 rdf:type schema:PublicationIssue
180 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
181 schema:name Medical and Health Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
184 schema:name Neurosciences
185 rdf:type schema:DefinedTerm
186 sg:grant.2401335 http://pending.schema.org/fundedItem sg:pub.10.1038/srep00954
187 rdf:type schema:MonetaryGrant
188 sg:grant.2439101 http://pending.schema.org/fundedItem sg:pub.10.1038/srep00954
189 rdf:type schema:MonetaryGrant
190 sg:grant.2439942 http://pending.schema.org/fundedItem sg:pub.10.1038/srep00954
191 rdf:type schema:MonetaryGrant
192 sg:grant.2441118 http://pending.schema.org/fundedItem sg:pub.10.1038/srep00954
193 rdf:type schema:MonetaryGrant
194 sg:grant.2447823 http://pending.schema.org/fundedItem sg:pub.10.1038/srep00954
195 rdf:type schema:MonetaryGrant
196 sg:grant.2448527 http://pending.schema.org/fundedItem sg:pub.10.1038/srep00954
197 rdf:type schema:MonetaryGrant
198 sg:grant.2504011 http://pending.schema.org/fundedItem sg:pub.10.1038/srep00954
199 rdf:type schema:MonetaryGrant
200 sg:grant.2504119 http://pending.schema.org/fundedItem sg:pub.10.1038/srep00954
201 rdf:type schema:MonetaryGrant
202 sg:grant.2561936 http://pending.schema.org/fundedItem sg:pub.10.1038/srep00954
203 rdf:type schema:MonetaryGrant
204 sg:grant.2562501 http://pending.schema.org/fundedItem sg:pub.10.1038/srep00954
205 rdf:type schema:MonetaryGrant
206 sg:grant.2617361 http://pending.schema.org/fundedItem sg:pub.10.1038/srep00954
207 rdf:type schema:MonetaryGrant
208 sg:grant.2683569 http://pending.schema.org/fundedItem sg:pub.10.1038/srep00954
209 rdf:type schema:MonetaryGrant
210 sg:journal.1045337 schema:issn 2045-2322
211 schema:name Scientific Reports
212 schema:publisher Springer Nature
213 rdf:type schema:Periodical
214 sg:person.01044126157.13 schema:affiliation grid-institutes:grid.34477.33
215 schema:familyName Goodlett
216 schema:givenName David R.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044126157.13
218 rdf:type schema:Person
219 sg:person.01065171014.45 schema:affiliation grid-institutes:grid.34477.33
220 schema:familyName Hu
221 schema:givenName Shu-Ching
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065171014.45
223 rdf:type schema:Person
224 sg:person.01117436013.50 schema:affiliation grid-institutes:grid.34477.33
225 schema:familyName Edgar
226 schema:givenName John Scott
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117436013.50
228 rdf:type schema:Person
229 sg:person.01154165643.22 schema:affiliation grid-institutes:grid.34477.33
230 schema:familyName Zabetian
231 schema:givenName Cyrus P.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154165643.22
233 rdf:type schema:Person
234 sg:person.01201417414.17 schema:affiliation grid-institutes:grid.34477.33
235 schema:familyName Pan
236 schema:givenName Catherine
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201417414.17
238 rdf:type schema:Person
239 sg:person.01214305720.20 schema:affiliation grid-institutes:grid.34477.33
240 schema:familyName Checkoway
241 schema:givenName Harvey
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214305720.20
243 rdf:type schema:Person
244 sg:person.013221630453.07 schema:affiliation grid-institutes:grid.34477.33
245 schema:familyName Zhang
246 schema:givenName Jing
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013221630453.07
248 rdf:type schema:Person
249 sg:person.01357504135.93 schema:affiliation grid-institutes:grid.4367.6
250 schema:familyName Racette
251 schema:givenName Brad A.
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357504135.93
253 rdf:type schema:Person
254 sg:person.0610440123.04 schema:affiliation grid-institutes:grid.34477.33
255 schema:familyName Shi
256 schema:givenName Min
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610440123.04
258 rdf:type schema:Person
259 sg:person.0623760204.30 schema:affiliation grid-institutes:grid.34477.33
260 schema:familyName Cain
261 schema:givenName Kevin C.
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623760204.30
263 rdf:type schema:Person
264 sg:person.0634514014.46 schema:affiliation grid-institutes:grid.34477.33
265 schema:familyName Cook
266 schema:givenName Travis J.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634514014.46
268 rdf:type schema:Person
269 sg:person.0651666711.76 schema:affiliation grid-institutes:None
270 schema:familyName Lin
271 schema:givenName Xiangmin
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651666711.76
273 rdf:type schema:Person
274 sg:person.0714314167.12 schema:affiliation grid-institutes:grid.34477.33
275 schema:familyName Montine
276 schema:givenName Thomas J.
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714314167.12
278 rdf:type schema:Person
279 sg:person.0717014774.70 schema:affiliation grid-institutes:grid.34477.33
280 schema:familyName Peskind
281 schema:givenName Elaine R.
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717014774.70
283 rdf:type schema:Person
284 sg:person.0775430702.19 schema:affiliation grid-institutes:grid.413919.7
285 schema:familyName Leverenz
286 schema:givenName James B.
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775430702.19
288 rdf:type schema:Person
289 sg:pub.10.1007/s10072-003-0108-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021024460
290 https://doi.org/10.1007/s10072-003-0108-0
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/nbt1046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040698216
293 https://doi.org/10.1038/nbt1046
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/nnano.2009.353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008023249
296 https://doi.org/10.1038/nnano.2009.353
297 rdf:type schema:CreativeWork
298 sg:pub.10.1039/c0pp00369g schema:sameAs https://app.dimensions.ai/details/publication/pub.1002829296
299 https://doi.org/10.1039/c0pp00369g
300 rdf:type schema:CreativeWork
301 grid-institutes:None schema:alternateName School of Life Sciences, Fujian Agricultural and Forestry University, 35002, Fuzhou, People's Republic of China
302 schema:name Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
303 School of Life Sciences, Fujian Agricultural and Forestry University, 35002, Fuzhou, People's Republic of China
304 rdf:type schema:Organization
305 grid-institutes:grid.34477.33 schema:alternateName Department of Biostatistics, University of Washington School of Public Health, Seattle, WA, USA
306 Department of Environmental & Occupational Health Sciences, University of Washington School of Public Health, Seattle, WA, USA
307 Department of Medicinal Chemistry, University of Washington School of Pharmacy, Seattle, WA, USA
308 Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA
309 Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
310 Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
311 schema:name Department of Biostatistics, University of Washington School of Public Health, Seattle, WA, USA
312 Department of Environmental & Occupational Health Sciences, University of Washington School of Public Health, Seattle, WA, USA
313 Department of Medicinal Chemistry, University of Washington School of Pharmacy, Seattle, WA, USA
314 Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA
315 Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
316 Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
317 Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
318 Mental Illness Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
319 Parkinson's Disease Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
320 rdf:type schema:Organization
321 grid-institutes:grid.413919.7 schema:alternateName Mental Illness Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
322 schema:name Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA
323 Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
324 Mental Illness Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
325 Parkinson's Disease Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
326 rdf:type schema:Organization
327 grid-institutes:grid.4367.6 schema:alternateName Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
328 schema:name Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
329 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...