JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytidine Deaminase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genomic Instability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Green Fluorescent Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HEK293 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Minor Histocompatibility Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Isoforms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-myc", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shinohara", 
        "givenName": "Masanobu", 
        "id": "sg:person.0756002542.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756002542.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Io", 
        "givenName": "Katsuhiro", 
        "id": "sg:person.01024115742.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024115742.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shindo", 
        "givenName": "Keisuke", 
        "id": "sg:person.01265057274.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265057274.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsui", 
        "givenName": "Masashi", 
        "id": "sg:person.01227621441.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227621441.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakamoto", 
        "givenName": "Takashi", 
        "id": "sg:person.01062515753.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062515753.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tada", 
        "givenName": "Kohei", 
        "id": "sg:person.01236122674.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236122674.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kobayashi", 
        "givenName": "Masayuki", 
        "id": "sg:person.01337525030.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337525030.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kadowaki", 
        "givenName": "Norimitsu", 
        "id": "sg:person.0626745174.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626745174.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate school of medicine, Kyoto University, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takaori-Kondo", 
        "givenName": "Akifumi", 
        "id": "sg:person.0743352217.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743352217.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nsmb.1497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045618057", 
          "https://doi.org/10.1038/nsmb.1497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.1799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041744551", 
          "https://doi.org/10.1038/ni.1799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35085588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013839107", 
          "https://doi.org/10.1038/35085588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2008-9-6-229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021664284", 
          "https://doi.org/10.1186/gb-2008-9-6-229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020929525", 
          "https://doi.org/10.1038/nature04255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029313751", 
          "https://doi.org/10.1038/nm1566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042589371", 
          "https://doi.org/10.1038/nature01709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2007.35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042884933", 
          "https://doi.org/10.1038/ng.2007.35"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/368258a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040515741", 
          "https://doi.org/10.1038/368258a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033482125", 
          "https://doi.org/10.1038/nature05610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014288207", 
          "https://doi.org/10.1038/nature08658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026224495", 
          "https://doi.org/10.1038/nature07969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002558962", 
          "https://doi.org/10.1038/nsmb.1744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038443548", 
          "https://doi.org/10.1038/nsmb.1598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-4690-5-51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009172880", 
          "https://doi.org/10.1186/1742-4690-5-51"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033148408", 
          "https://doi.org/10.1038/ng.438"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-11-13", 
    "datePublishedReg": "2012-11-13", 
    "description": "Human APOBEC3 proteins play pivotal roles in intracellular defense against viral infection by catalyzing deamination of cytidine residues, leading to base substitutions in viral DNA. Activation-induced cytidine deaminase (AID), another member of the APOBEC family, is capable of editing immunoglobulin (Ig) and non-Ig genes and aberrant expression of AID leads to tumorigenesis. However, it remains unclear whether APOBEC3 (A3) proteins affect stability of human genome. Here we demonstrate that both A3A and A3B can induce base substitutions into human genome as AID can. A3B is highly expressed in several lymphoma cells and somatic mutations occur in some oncogenes of the cells highly expressing A3B. Furthermore, transfection of A3B gene into lymphoma cells induces base substitutions in cMYC gene. These data suggest that aberrant expression of A3B can evoke genomic instability by inducing base substitutions into human genome, which might lead to tumorigenesis in human cells.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/srep00806", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6057578", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6086083", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "keywords": [
      "activation-induced cytidine deaminase", 
      "human genome", 
      "base substitutions", 
      "human cells", 
      "APOBEC3 proteins", 
      "non-Ig genes", 
      "aberrant expression", 
      "human APOBEC3 proteins", 
      "A3B gene", 
      "genomic stability", 
      "genomic instability", 
      "APOBEC family", 
      "genomic DNA", 
      "lymphoma cells", 
      "cytidine residues", 
      "genome", 
      "cMyc gene", 
      "intracellular defense", 
      "cytidine deaminase", 
      "genes", 
      "somatic mutations", 
      "viral DNA", 
      "protein", 
      "DNA", 
      "pivotal role", 
      "tumorigenesis", 
      "cells", 
      "expression", 
      "substitution", 
      "viral infection", 
      "A3B", 
      "oncogene", 
      "transfection", 
      "mutations", 
      "A3A", 
      "residues", 
      "APOBEC3B", 
      "A3B.", 
      "deamination", 
      "deaminase", 
      "defense", 
      "family", 
      "members", 
      "role", 
      "infection", 
      "stability", 
      "immunoglobulin", 
      "data", 
      "instability"
    ], 
    "name": "APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells", 
    "pagination": "806", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032985769"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep00806"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23150777"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep00806", 
      "https://app.dimensions.ai/details/publication/pub.1032985769"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T16:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_560.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/srep00806"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

289 TRIPLES      21 PREDICATES      104 URIs      80 LITERALS      21 BLANK NODES