APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Masanobu Shinohara, Katsuhiro Io, Keisuke Shindo, Masashi Matsui, Takashi Sakamoto, Kohei Tada, Masayuki Kobayashi, Norimitsu Kadowaki, Akifumi Takaori-Kondo

ABSTRACT

Human APOBEC3 proteins play pivotal roles in intracellular defense against viral infection by catalyzing deamination of cytidine residues, leading to base substitutions in viral DNA. Activation-induced cytidine deaminase (AID), another member of the APOBEC family, is capable of editing immunoglobulin (Ig) and non-Ig genes, and aberrant expression of AID leads to tumorigenesis. However, it remains unclear whether APOBEC3 (A3) proteins affect stability of human genome. Here we demonstrate that both A3A and A3B can induce base substitutions into human genome as AID can. A3B is highly expressed in several lymphoma cells and somatic mutations occur in some oncogenes of the cells highly expressing A3B. Furthermore, transfection of A3B gene into lymphoma cells induces base substitutions in cMYC gene. These data suggest that aberrant expression of A3B can evoke genomic instability by inducing base substitutions into human genome, which might lead to tumorigenesis in human cells. More... »

PAGES

806

References to SciGraph publications

  • 2008-12. HIV-1 Vif, APOBEC, and Intrinsic Immunity in RETROVIROLOGY
  • 2007-03. Patterns of somatic mutation in human cancer genomes in NATURE
  • 2009-05. Active nuclear import and cytoplasmic retention of activation-induced deaminase in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-07. The tektin family of microtubule-stabilizing proteins in GENOME BIOLOGY
  • 2008-11. Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-01. AID is required for germinal center–derived lymphomagenesis in NATURE GENETICS
  • 2008-10. The AID/APOBEC family of nucleic acid mutators in GENOME BIOLOGY
  • 2010-02. APOBEC3 proteins mediate the clearance of foreign DNA from human cells in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2009-10. Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4 in NATURE GENETICS
  • 2009-11. A coming-of-age story: activation-induced cytidine deaminase turns 10 in NATURE IMMUNOLOGY
  • 2010-01. A comprehensive catalogue of somatic mutations from a human cancer genome in NATURE
  • 2009-06. Frequent inactivation of A20 in B-cell lymphomas in NATURE
  • 2003-07. Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts in NATURE
  • 2001-07. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas in NATURE
  • 2007-04. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium in NATURE MEDICINE
  • 2005-11. The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation in NATURE
  • 1994-03. Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep00806

    DOI

    http://dx.doi.org/10.1038/srep00806

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032985769

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23150777


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