Rapid Nipah virus entry into the central nervous system of hamsters via the olfactory route View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-10-15

AUTHORS

Vincent J. Munster, Joseph B. Prescott, Trenton Bushmaker, Dan Long, Rebecca Rosenke, Tina Thomas, Dana Scott, Elizabeth R. Fischer, Heinz Feldmann, Emmie de Wit

ABSTRACT

Encephalitis is a hallmark of Nipah virus (NiV) infection in humans. The exact route of entry of NiV into the central nervous system (CNS) is unknown. Here, we performed a spatio-temporal analysis of NiV entry into the CNS of hamsters. NiV initially predominantly targeted the olfactory epithelium in the nasal turbinates. From there, NiV infected neurons were visible extending through the cribriform plate into the olfactory bulb, providing direct evidence of rapid CNS entry. Subsequently, NiV disseminated to the olfactory tubercle and throughout the ventral cortex. Transmission electron microscopy on brain tissue showed extravasation of plasma cells, neuronal degeneration and nucleocapsid inclusions in affected tissue and axons, providing further evidence for axonal transport of NiV. NiV entry into the CNS coincided with the occurrence of respiratory disease, suggesting that the initial entry of NiV into the CNS occurs simultaneously with, rather than as a result of, systemic virus replication. More... »

PAGES

736

References to SciGraph publications

  • 2005-03. Olfactory transmission of neurotropic viruses in JOURNAL OF NEUROVIROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep00736

    DOI

    http://dx.doi.org/10.1038/srep00736

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009085386

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23071900


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