Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12-12

AUTHORS

María Guillamot, Eusebio Manchado, Massimo Chiesa, Gonzalo Gómez-López, David G. Pisano, María P. Sacristán, Marcos Malumbres

ABSTRACT

Cdc14 is an essential phosphatase in yeast but its role in the mammalian cell cycle remains obscure. We report here that Cdc14b-knockout cells display unscheduled induction of multiple cell cycle regulators resulting in early entry into DNA replication and mitosis from quiescence. Cdc14b dephosphorylates Ser5 at the C-terminal domain (CTD) of RNA polymerase II, a major substrate of cyclin-dependent kinases. Lack of Cdc14b results in increased CTD-Ser5 phosphorylation, epigenetic modifications that mark active chromatin, and transcriptional induction of cell cycle regulators. These data suggest a function for mammalian Cdc14 phosphatases in the control of transcription during the cell cycle. More... »

PAGES

189

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep00189

DOI

http://dx.doi.org/10.1038/srep00189

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047028605

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22355704


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