Inactivation of CBF/NF-Y in postnatal liver causes hepatocellular degeneration, lipid deposition and endoplasmic reticulum stress View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-11-01

AUTHORS

Rong Luo, Sherry A. Klumpp, Milton J. Finegold, Sankar N. Maity

ABSTRACT

We previously demonstrated that CBF activity is needed for cell proliferation and early embryonic development. To examine the in vivo function of CBF in differentiated hepatocytes, we conditionally deleted CBF-B in hepatocytes after birth. Deletion of CBF-B resulted in progressive liver injury and severe hepatocellular degeneration 4 weeks after birth. Electron microscopic examination demonstrated pleiotropic changes of hepatocytes including enlarged cell and nuclear size, intracellular lipid deposition, disorganized endoplasmic reticulum and mitochondrial abnormalities. Gene expression analyses showed that deletion of CBF-B activated expression of specific endoplasmic reticulum (ER) stress-regulated genes. Inactivation of CBF-B also inhibited expression of C/EBP alpha, an important transcription factor controlling various metabolic processes in adult hepatocytes. Altogether, our study reveals for the first time that CBF is a key transcription factor controlling ER function and metabolic processes in mature hepatocytes. More... »

PAGES

136

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep00136

DOI

http://dx.doi.org/10.1038/srep00136

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005022755

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22355653


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218 grid-institutes:grid.240145.6 schema:alternateName SNM Department of Genitourinary Medical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX
219 schema:name Genes and Development Program, Graduate School of Biomedical Sciences, The University of Texas
220 Molecular Genetics
221 SNM Department of Genitourinary Medical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX
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223 grid-institutes:grid.38142.3c schema:alternateName RL Division of Newborn Medicine, Department of Medicine, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA
224 schema:name Genes and Development Program, Graduate School of Biomedical Sciences, The University of Texas
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226 RL Division of Newborn Medicine, Department of Medicine, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA
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228 grid-institutes:grid.416975.8 schema:alternateName Department of Pathology, Texas Children’s Hospital, 77030, Houston, Texas
229 schema:name Department of Pathology, Texas Children’s Hospital, 77030, Houston, Texas
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