Ontology type: schema:ScholarlyArticle Open Access: True
2011-12
AUTHORSSilvia Landi, Elena Putignano, Elena Maria Boggio, Maurizio Giustetto, Tommaso Pizzorusso, Gian Michele Ratto
ABSTRACTThe maturation of excitatory transmission comes about through a developmental period in which dendritic spines are highly motile and their number, form and size are rapidly changing. Surprisingly, although these processes are crucial for the formation of cortical circuitry, little is known about possible alterations of these processes in brain disease. By means of acute in vivo 2-photon imaging we show that the dynamic properties of dendritic spines of layer V cortical neurons are deeply affected in a mouse model of Rett syndrome (RTT) at a time around P25 when the neuronal phenotype of the disease is still mild. Then, we show that 24h after a subcutaneous injection of IGF-1 spine dynamics is restored. Our study demonstrates that spine dynamics in RTT mice is severely impaired early during development and suggest that treatments for RTT should be started very early in order to reestablish a normal period of spine plasticity. More... »
PAGES45
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DOIhttp://dx.doi.org/10.1038/srep00045
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/22355564
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep00045'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep00045'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep00045'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep00045'
This table displays all metadata directly associated to this object as RDF triples.
326 TRIPLES
21 PREDICATES
93 URIs
28 LITERALS
16 BLANK NODES