Ontology type: schema:ScholarlyArticle Open Access: True
2008-08
AUTHORSA Ruzzo, F Graziano, F Loupakis, D Santini, V Catalano, R Bisonni, R Ficarelli, A Fontana, F Andreoni, A Falcone, E Canestrari, G Tonini, D Mari, P Lippe, F Pizzagalli, G Schiavon, P Alessandroni, L Giustini, P Maltese, E Testa, E T Menichetti, M Magnani
ABSTRACTThe primary end point of the study was the analysis of associations between polymorphisms with putative influence on 5-fluorouracil/irinotecan activity and progression-free survival (PFS) of patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy. Peripheral blood samples from 146 prospectively enrolled patients were used for genotyping polymorphisms in thymidylate synthase (TS), methylenetetrahydrofolate reductase (MTHFR), excision repair cross-complementation group-1 (ERCC 1) xeroderma pigmentosum group-D (XPD), X-ray cross-complementing-1 (XRCC 1), X-ray cross-complementing-3 (XRCC 3) and uridine diphosphate-glucuronosyltransferases-A1 (UGT1 A1). TS 3'-UTR 6+/6+ and XRCC3-241 C/C genotypes were associated with adverse PFS. Hazard ratio for PFS achieved 2.89 (95% confidence interval=1.56-5.80; P=0.002) in 30 patients (20%) with both risk genotypes. Risk for Grade III-IV neutropenia was significantly associated with UGT1A1*28 7/7 genotype. These promising findings deserve further investigations and their validation in independent prospective studies. More... »
PAGES278
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DOIhttp://dx.doi.org/10.1038/sj.tpj.6500463
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/17549067
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