Use of pairwise marker combination and recursive partitioning in a pharmacogenetic genome-wide scan View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-06

AUTHORS

L L Warren, A R Hughes, E H Lai, D V Zaykin, S A Haneline, A T Bansal, A W Wooster, W R Spreen, J E Hernandez, T R Scott, A D Roses, M Mosteller

ABSTRACT

The objective of pharmacogenetic research is to identify a genetic marker, or a set of genetic markers, that can predict how a given person will respond to a given medicine. To search for such marker combinations that are predictive of adverse drug events, we have developed and applied two complementary methods to a pharmacogenetic study of the hypersensitivity reaction (HSR) associated with treatment with abacavir, a medicine that is used to treat HIV-infected patients. Our results show that both of these methods can be used to uncover potentially useful predictive marker combinations. The pairwise marker combination method yielded a collection of marker pairs that featured a spectrum of sensitivities and specificities. Recursive partitioning results led to the genetic delineation of multiple risk categories, including those with extremely high and extremely low risk of HSR. These methods can be readily applied in pharmacogenetic candidate gene studies as well as in genome-wide scans. More... »

PAGES

180

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.tpj.6500414

DOI

http://dx.doi.org/10.1038/sj.tpj.6500414

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039020569

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16969363


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.tpj.6500414'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.tpj.6500414'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.tpj.6500414'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.tpj.6500414'


 

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