Activation and regulation of ATM kinase activity in response to DNA double-strand breaks View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-12

AUTHORS

J-H Lee, T T Paull

ABSTRACT

The ataxia-telangiectasia-mutated (ATM) protein kinase is rapidly and specifically activated in response to DNA double-strand breaks in eukaryotic cells. In this review, we summarize recent insights into the mechanism of ATM activation, focusing on the role of the Mre11/Rad50/Nbs1 (MRN) complex in this process. We also compare observations of the ATM activation process in different biological systems and highlight potential candidates for cellular factors that may participate in regulating ATM activity in human cells. More... »

PAGES

1210872

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1210872

    DOI

    http://dx.doi.org/10.1038/sj.onc.1210872

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051326997

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18066086


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